STRINGSTRING
his-45 his-45 his-47 his-47 his-48 his-48 his-46 his-46 C06A5.3 C06A5.3 set-4 set-4 met-1 met-1 his-35 his-35 his-41 his-41 his-37 his-37 nap-1 nap-1 set-8 set-8 his-51 his-51 his-54 his-54 his-53 his-53 his-52 his-52 his-49 his-49 his-50 his-50 his-44 his-44 his-43 his-43 his-42 his-42 his-32 his-32 his-31 his-31 his-33 his-33 his-34 his-34 his-64 his-64 his-63 his-63 his-30 his-30 his-71 his-71 his-6 his-6 his-39 his-39 his-5 his-5 his-7 his-7 his-55 his-55 his-56 his-56 his-61 his-61 his-60 his-60 his-59 his-59 his-62 his-62 his-65 his-65 chd-1 chd-1 his-40 his-40 his-38 his-38 his-18 his-18 his-19 his-19 his-22 his-22 his-27 his-27 his-28 his-28 his-21 his-21 his-20 his-20 his-17 his-17 hat-1 hat-1 his-4 his-4 his-2 his-2 his-1 his-1 his-67 his-67 his-68 his-68 set-1 set-1 bet-1 bet-1 his-26 his-26 his-16 his-16 his-9 his-9 his-10 his-10 his-12 his-12 his-13 his-13 his-14 his-14 his-15 his-15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-45Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
his-47Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
C06A5.3PWWP domain-containing protein. (783 aa)
set-4Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway. (288 aa)
met-1Histone-lysine N-methyltransferase. (1604 aa)
his-35Histone H2A; Belongs to the histone H2A family. (127 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-37Histone H4. (103 aa)
nap-1Nucleosome Assembly Protein; Belongs to the nucleosome assembly protein (NAP) family. (316 aa)
set-8SET domain-containing protein. (512 aa)
his-51Histone H2A. (127 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-53Histone H2A. (127 aa)
his-52Histone H2B 2. (123 aa)
his-49Histone H3. (136 aa)
his-50Histone H4. (103 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
his-43Histone H2A. (127 aa)
his-42Histone H3. (136 aa)
his-32Histone H3. (136 aa)
his-31Histone H4. (103 aa)
his-33Histone H2A. (127 aa)
his-34Histone H2B 1. (122 aa)
his-64Histone H4. (103 aa)
his-63Histone H3. (136 aa)
his-30Histone H2A. (127 aa)
his-71Histone H3.3 type 1; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central [...] (136 aa)
his-6Histone H3. (136 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
his-5Histone H4. (103 aa)
his-7Histone H2A. (127 aa)
his-55Histone H3. (136 aa)
his-56Histone H4. (103 aa)
his-61Histone H2A. (127 aa)
his-60Histone H4. (103 aa)
his-59Histone H3. (136 aa)
his-62Probable histone H2B 4. (123 aa)
his-65Histone H2A. (127 aa)
chd-1Chromodomain and Helicase Domain protein. (1461 aa)
his-40Histone H3. (136 aa)
his-38Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-19Histone H2A. (127 aa)
his-22Histone H2B 2. (123 aa)
his-27Histone H3. (136 aa)
his-28Histone H4. (103 aa)
his-21Histone H2A. (127 aa)
his-20Histone H2B 2. (123 aa)
his-17Histone H3. (136 aa)
hat-1Hat1_N domain-containing protein. (411 aa)
his-4Histone H2B 2. (123 aa)
his-2Histone H3. (136 aa)
his-1Histone H4. (103 aa)
his-67Histone H4. (103 aa)
his-68Histone H2A. (127 aa)
set-1Histone-lysine N-methyltransferase set-1; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily. (242 aa)
bet-1Bromodomain-containing protein bet-1; Required for the establishment and maintenance of stable cell fate in several lineages including V5.pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants. Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22. Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells. Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway. I [...] (853 aa)
his-26Histone H4. (103 aa)
his-16Histone H2A. (127 aa)
his-9Histone H3. (136 aa)
his-10Histone H4. (103 aa)
his-12Histone H2A. (127 aa)
his-13Histone H3. (136 aa)
his-14Histone H4. (103 aa)
his-15Histone H2B 1. (122 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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