STRINGSTRING
his-45 his-45 his-49 his-49 his-43 his-43 his-42 his-42 his-32 his-32 his-63 his-63 his-71 his-71 his-6 his-6 his-55 his-55 his-61 his-61 his-59 his-59 his-40 his-40 his-27 his-27 his-17 his-17 his-2 his-2 his-13 his-13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-45Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
his-49Histone H3. (136 aa)
his-43Histone H2A. (127 aa)
his-42Histone H3. (136 aa)
his-32Histone H3. (136 aa)
his-63Histone H3. (136 aa)
his-71Histone H3.3 type 1; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central [...] (136 aa)
his-6Histone H3. (136 aa)
his-55Histone H3. (136 aa)
his-61Histone H2A. (127 aa)
his-59Histone H3. (136 aa)
his-40Histone H3. (136 aa)
his-27Histone H3. (136 aa)
his-17Histone H3. (136 aa)
his-2Histone H3. (136 aa)
his-13Histone H3. (136 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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