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| | amx-2 | Amino_oxidase domain-containing protein. (724 aa) |
| | sir-2.4 | NAD-dependent protein deacetylase sir-2.4; NAD-dependent protein deacetylase. (292 aa) |
| | pro-2 | Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation. (715 aa) |
| | atf-7 | BZIP domain-containing protein. (509 aa) |
| | hda-2 | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] (507 aa) |
| | egl-5 | Homeobox protein egl-5; Essential for the determination of specific neurons. (223 aa) |
| | mab-5 | Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family. (200 aa) |
| | mes-6 | Polycomb protein mes-6; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to ex [...] (459 aa) |
| | hda-4 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development. (869 aa) |
| | ceh-16 | Homeobox protein engrailed-like ceh-16; Required in the seam cells during embryonic development. Represses the fusion of the seam cells with the neighboring dorsal and ventral epidermal cells by repressing the expression of the fusion effector eff-1. Required for early seam cell differentiation. Triggers the expression of elt-5 and other seam cell markers and is indispensable for alae formation (a hallmark of seam cell differentiation). Required for the maintenance of correct boundaries between the lateral rows of seam cells and the ventral and dorsal row of epidermal cells during embr [...] (187 aa) |
| | nfx-1 | Transcriptional repressor NF-X1 homolog; May play a role in transcription regulation; Belongs to the NFX1 family. (1119 aa) |
| | C16C10.8 | Uncharacterized protein C16C10.8. (253 aa) |
| | nsy-7 | Neuronal SYmmetry. (294 aa) |
| | sdc-3 | Zinc finger protein sdc-3; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reductio [...] (2150 aa) |
| | dcp-66 | Deacetylase Complex Protein. (724 aa) |
| | nhr-2 | Nuclear hormone receptor family member nhr-2; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (472 aa) |
| | elt-2 | Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa) |
| | sdc-2 | Sex determination and dosage compensation protein sdc-2; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto [...] (2962 aa) |
| | lin-1 | ETS domain-containing protein. (441 aa) |
| | elt-4 | GATA-type domain-containing protein. (72 aa) |
| | met-1 | Histone-lysine N-methyltransferase. (1604 aa) |
| | athp-1 | AT Hook plus PHD finger transcription factor. (1150 aa) |
| | hcf-1 | Host cell factor 1. (782 aa) |
| | unc-130 | Fork-head domain-containing protein. (333 aa) |
| | hda-1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] (461 aa) |
| | ztf-3 | Zinc finger putative Transcription Factor family. (336 aa) |
| | uri-1 | URI (Unconventional prefoldin RPB5 Interactor) homolog. (446 aa) |
| | wdr-23 | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa) |
| | sin-3 | Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). (1507 aa) |
| | prdx-2 | Thioredoxin domain-containing protein. (201 aa) |
| | F10E7.11 | ELM2 domain-containing protein. (239 aa) |
| | daf-12 | Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa) |
| | hbl-1 | Hunchback-like protein; Required for the late stages of development. Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production. (982 aa) |
| | sem-4 | SEM-4 long form. (744 aa) |
| | phf-32 | PHD domain-containing protein. (208 aa) |
| | F19F10.1 | ETS domain-containing protein. (210 aa) |
| | ets-7 | ETS domain-containing protein. (218 aa) |
| | F21A9.2 | C2H2-type domain-containing protein. (392 aa) |
| | blmp-1 | B lymphocyte-induced maturation protein 1 homolog; Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip m [...] (817 aa) |
| | daf-3 | Dwarfin sma. (895 aa) |
| | let-418 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa) |
| | zag-1 | Zinc finger E-box-binding homeobox protein zag-1; Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron- specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Required for axon guidance. Involved in the proper development of the pharynx. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter. (596 aa) |
| | ubc-9 | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa) |
| | fos-1 | Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily. (467 aa) |
| | daf-6 | SSD domain-containing protein. (913 aa) |
| | nhr-8 | Nuclear hormone receptor family member nhr-8; Orphan nuclear receptor. (560 aa) |
| | tlf-1 | TBP-Like Factor. (508 aa) |
| | drap-1 | CBFD_NFYB_HMF domain-containing protein. (331 aa) |
| | hda-6 | Histone deacetylase 6; Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (957 aa) |
| | hda-5 | Hist_deacetyl domain-containing protein. (508 aa) |
| | F43G6.17 | Hist_deacetyl domain-containing protein. (281 aa) |
| | ces-1 | CEll death Specification. (270 aa) |
| | sex-1 | Steroid hormone receptor family member cnr14; Belongs to the nuclear hormone receptor family. NR1 subfamily. (534 aa) |
| | pag-3 | Zinc finger protein PAG-3. (336 aa) |
| | lin-42 | Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...] (654 aa) |
| | ctbp-1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. (727 aa) |
| | elt-6 | GATA-like transcription factor ELT-6. (367 aa) |
| | pos-1 | Cytoplasmic zinc-finger protein. (264 aa) |
| | sdc-1 | Zinc finger protein sdc-1; Embryonic transcription factor regulating downstream genes involved specifically in the sex determination and dosage compensation pathways, or regulating other genes involved in the coordinate control of both processes. Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Involved in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodit [...] (1201 aa) |
| | ztf-11 | Zinc finger protein ztf-11; Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis. Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis. Required for the generation of postembryonic neurons from epidermal cells. Belongs to the MYT1 family. (539 aa) |
| | dro-1 | CBFD_NFYB_HMF domain-containing protein. (184 aa) |
| | nhr-7 | Nuclear hormone receptor family member nhr-7; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (536 aa) |
| | dnj-13 | J domain-containing protein. (331 aa) |
| | egl-18 | GATA-type domain-containing protein. (379 aa) |
| | unc-55 | Nuclear hormone receptor unc-55; Acts as a transcriptional regulator. Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern. Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern. Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation. This prevents respecification of synapses by VD neurons. During copulation, required in males for correct movement of the spicules, a pair of prong-like structures whi [...] (370 aa) |
| | bro-1 | BROther (Drosophila tx factor partner) homolog. (152 aa) |
| | ldb-1 | LID domain-containing protein. (629 aa) |
| | end-3 | GATA-type domain-containing protein. (242 aa) |
| | elt-3 | GATA-type domain-containing protein. (317 aa) |
| | med-2 | GATA-type domain-containing protein. (174 aa) |
| | sel-7 | Suppressor/Enhancer of Lin-12. (324 aa) |
| | lag-1 | Lin-12 And Glp-1 phenotype. (790 aa) |
| | atf-2 | ATF (cAMP-dependent transcription factor) family. (401 aa) |
| | hpl-1 | Heterochromatin protein 1 homolog. (184 aa) |
| | egl-46 | C2H2-type domain-containing protein. (286 aa) |
| | smo-1 | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa) |
| | daf-8 | Dwarfin sma. (546 aa) |
| | met-2 | Histone-lysine N-methyltransferase met-2; Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish betwee [...] (1304 aa) |
| | hda-3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (465 aa) |
| | amx-1 | Amine oxidase family member 1. (824 aa) |
| | daf-16 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa) |
| | egl-43 | Uncharacterized protein. (543 aa) |
| | ref-1 | REgulator of Fusion. (367 aa) |
| | T07F8.4 | ELM2 domain-containing protein. (345 aa) |
| | lsd-1 | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa) |
| | cec-3 | Chromo domain-containing protein cec-3; Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc- 4 is expressed in the vulval but not in the non-vulval VC neurons. (339 aa) |
| | cec-6 | Chromo domain-containing protein. (891 aa) |
| | chd-3 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. (1787 aa) |
| | mml-1 | Protein WBSCR14 homolog; Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3' (By similarity). (1009 aa) |
| | cfi-1 | AT-rich interactive domain-containing protein cfi-1; Transcription factor which regulates neuronal subtype identity. Promotes differentiation of URA sensory neurons and prevents them to express male-specific CEM features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression. (467 aa) |
| | dpl-1 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] (598 aa) |
| | nhr-69 | Nuclear hormone receptor family member nhr-69; Orphan nuclear receptor. (373 aa) |
| | med-1 | GATA-type domain-containing protein. (174 aa) |
| | lin-14 | Protein lin-14; Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin- like growth factor gene ins-33. Isoform A may be involved in specifying L1 cell fates while isoform B1 and isoform B2 may specify L2 and later cell fates, creating a temporal switch. (539 aa) |
| | ceh-39 | Homeobox protein ceh-39; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family. (399 aa) |
| | lin-40 | Uncharacterized protein. (1022 aa) |
| | daf-5 | C-SKI_SMAD_bind domain-containing protein. (627 aa) |
| | nhr-85 | Nuclear hormone receptor family member nhr-85; Orphan nuclear receptor. (514 aa) |
| | elt-1 | Transcription factor elt-1; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses ex [...] (488 aa) |
| | mef-2 | MADS-box domain-containing protein. (340 aa) |
| | ekl-4 | Uncharacterized protein. (488 aa) |
| | mrg-1 | MRG domain-containing protein. (337 aa) |
| | Y37H9A.3 | Coiled-coil and C2 domain-containing protein 1-like; Belongs to the CC2D1 family. (792 aa) |
| | Y39E4B.6 | Uncharacterized protein. (237 aa) |
| | spr-5 | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] (770 aa) |
| | tra-1 | Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By s [...] (1110 aa) |
| | pie-1 | Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex. (335 aa) |
| | hda-10 | Hist_deacetyl domain-containing protein. (517 aa) |
| | mab-3 | Protein male abnormal 3; Transcription factor which binds the DNA motif 5'- [CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer. Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. Promotes male-specific development of two tissues, the peripheral nervous system and the intestine. In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, causes repression of vitellogenin gene transcription. (290 aa) |
| | clk-1 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner; Belongs to the COQ7 family. (187 aa) |
| | ham-3 | SWIB domain-containing protein. (446 aa) |
| | cec-1 | Chromo domain-containing protein cec-1. (304 aa) |
| | lin-37 | Uncharacterized protein. (275 aa) |
| | nhr-48 | Nuclear hormone receptor family member nhr-48; Orphan nuclear receptor. (817 aa) |
| | hlh-10 | BHLH domain-containing protein. (202 aa) |
