STRINGSTRING
swp-1 swp-1 spk-1 spk-1 B0495.8 B0495.8 unc-75 unc-75 C50D2.8 C50D2.8 D1007.4 D1007.4 F08B4.7 F08B4.7 usp-39 usp-39 repo-1 repo-1 F25B4.5 F25B4.5 isy-1 isy-1 mog-2 mog-2 M03F8.3 M03F8.3 etr-1 etr-1 sftb-1 sftb-1 rsp-3 rsp-3 Y119D3B.12 Y119D3B.12 smi-1 smi-1 rnp-6 rnp-6 uaf-1 uaf-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
swp-1Protein SWAP; It is a regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). It may regulate its own expression at the level of RNA processing. (751 aa)
spk-1Serine/threonine-protein kinase spk-1; Required for embryogenesis and germline development in both adult hermaphrodites and males. SR-protein kinase (SRPK) that binds directly to and phosphorylates the RS domain of rsp-3/CeSF2 in vitro. (1003 aa)
B0495.8Uncharacterized protein B0495.8; Belongs to the Luc7 family. (313 aa)
unc-75RRM domain-containing protein. (514 aa)
C50D2.8Uncharacterized protein. (319 aa)
D1007.4Uncharacterized protein. (168 aa)
F08B4.7U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (142 aa)
usp-39Ubiquitin Specific Protease. (602 aa)
repo-1Matrin-type domain-containing protein. (222 aa)
F25B4.5Uncharacterized protein. (710 aa)
isy-1Protein isy-1; Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10. Does not affect the splicing of zip-10 ; Belongs to the ISY1 family. (267 aa)
mog-2Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing. (253 aa)
M03F8.3Uncharacterized protein. (747 aa)
etr-1RRM domain-containing protein. (589 aa)
sftb-1SF3b1 domain-containing protein. (1322 aa)
rsp-3Probable splicing factor, arginine/serine-rich 3; Plays an essential role in embryogenesis. (258 aa)
Y119D3B.12Uncharacterized protein. (339 aa)
smi-1Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (254 aa)
rnp-6RNP (RRM RNA binding domain) containing. (749 aa)
uaf-1Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (496 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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