STRINGSTRING
rfs-1 rfs-1 mus-81 mus-81 xpf-1 xpf-1 F35H10.5 F35H10.5 lem-3 lem-3 F44E5.15 F44E5.15 slx-1 slx-1 eme-1 eme-1 K07D4.2 K07D4.2 top-2 top-2 rmh-1 rmh-1 R05D3.12 R05D3.12 him-6 him-6 him-18 him-18 rmh-2 rmh-2 him-17 him-17 helq-1 helq-1 him-14 him-14 cin-4 cin-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfs-1RAD51-like protein 1; Has a role in the homologous recombination repair (HRR) of genomic DNA during meiosis. Required for rad-51 recruitment onto ssDNA gaps generated at stalled replication fork barriers. (245 aa)
mus-81ERCC4 domain-containing protein. (445 aa)
xpf-1ERCC4 domain-containing protein. (935 aa)
F35H10.5Uncharacterized protein. (79 aa)
lem-3Ankyrin repeat and LEM domain-containing protein 1 homolog; Endonuclease which, in association with baf-1, plays an essential role during embryogenesis in the DNA repair response following DNA damage probably by ensuring proper chromosome segregation. Also required during postembryonic cell divisions after DNA damage caused by ionizing radiation to ensure normal cell proliferation. Resolves chromatin bridges in late mitosis that result from incomplete DNA replication, defective chromosome condensation or unresolved recombination intermediates. Together with brc-1, contributes to genome [...] (704 aa)
F44E5.15Uncharacterized protein. (222 aa)
slx-1Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] (443 aa)
eme-1Essential Meiotic Endonuclease. (454 aa)
K07D4.2Uncharacterized protein. (194 aa)
top-2DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...] (1520 aa)
rmh-1DUF1767 domain-containing protein. (926 aa)
R05D3.12Putative DNA topoisomerase 2, mitochondrial; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity); Belongs to the type II topoisomerase family. (1170 aa)
him-6Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. (988 aa)
him-18High Incidence of Males (Increased X chromosome loss). (718 aa)
rmh-2DUF1767 domain-containing protein. (615 aa)
him-17High Incidence of Males (Increased X chromosome loss). (954 aa)
helq-1Helicase C-terminal domain-containing protein. (923 aa)
him-14MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. (842 aa)
cin-4DNA topoisomerase-like protein cin-4; Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution. Belongs to the type II topoisomerase family. (842 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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