node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
R05D3.12 | cin-4 | R05D3.12a.1 | ZK1127.7.1 | Putative DNA topoisomerase 2, mitochondrial; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity); Belongs to the type II topoisomerase family. | DNA topoisomerase-like protein cin-4; Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution. Belongs to the type II topoisomerase family. | 0.499 |
R05D3.12 | him-6 | R05D3.12a.1 | T04A11.6.1 | Putative DNA topoisomerase 2, mitochondrial; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity); Belongs to the type II topoisomerase family. | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. | 0.488 |
R05D3.12 | top-2 | R05D3.12a.1 | K12D12.1.1 | Putative DNA topoisomerase 2, mitochondrial; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity); Belongs to the type II topoisomerase family. | DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...] | 0.439 |
cin-4 | R05D3.12 | ZK1127.7.1 | R05D3.12a.1 | DNA topoisomerase-like protein cin-4; Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution. Belongs to the type II topoisomerase family. | Putative DNA topoisomerase 2, mitochondrial; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity); Belongs to the type II topoisomerase family. | 0.499 |
cin-4 | him-6 | ZK1127.7.1 | T04A11.6.1 | DNA topoisomerase-like protein cin-4; Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution. Belongs to the type II topoisomerase family. | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. | 0.514 |
cin-4 | top-2 | ZK1127.7.1 | K12D12.1.1 | DNA topoisomerase-like protein cin-4; Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution. Belongs to the type II topoisomerase family. | DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...] | 0.422 |
eme-1 | him-18 | F56A6.4a.1 | T04A8.15.1 | Essential Meiotic Endonuclease. | High Incidence of Males (Increased X chromosome loss). | 0.791 |
eme-1 | mus-81 | F56A6.4a.1 | C43E11.2a.1 | Essential Meiotic Endonuclease. | ERCC4 domain-containing protein. | 0.959 |
eme-1 | slx-1 | F56A6.4a.1 | F56A3.2.1 | Essential Meiotic Endonuclease. | Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] | 0.806 |
eme-1 | xpf-1 | F56A6.4a.1 | C47D12.8.1 | Essential Meiotic Endonuclease. | ERCC4 domain-containing protein. | 0.775 |
helq-1 | him-6 | Y55B1AL.3a.1 | T04A11.6.1 | Helicase C-terminal domain-containing protein. | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. | 0.841 |
helq-1 | mus-81 | Y55B1AL.3a.1 | C43E11.2a.1 | Helicase C-terminal domain-containing protein. | ERCC4 domain-containing protein. | 0.808 |
helq-1 | rfs-1 | Y55B1AL.3a.1 | C30A5.2.1 | Helicase C-terminal domain-containing protein. | RAD51-like protein 1; Has a role in the homologous recombination repair (HRR) of genomic DNA during meiosis. Required for rad-51 recruitment onto ssDNA gaps generated at stalled replication fork barriers. | 0.955 |
helq-1 | slx-1 | Y55B1AL.3a.1 | F56A3.2.1 | Helicase C-terminal domain-containing protein. | Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] | 0.517 |
helq-1 | xpf-1 | Y55B1AL.3a.1 | C47D12.8.1 | Helicase C-terminal domain-containing protein. | ERCC4 domain-containing protein. | 0.570 |
him-14 | him-18 | ZK1127.11.1 | T04A8.15.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | High Incidence of Males (Increased X chromosome loss). | 0.855 |
him-14 | him-6 | ZK1127.11.1 | T04A11.6.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. | 0.902 |
him-14 | mus-81 | ZK1127.11.1 | C43E11.2a.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | ERCC4 domain-containing protein. | 0.979 |
him-14 | rfs-1 | ZK1127.11.1 | C30A5.2.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | RAD51-like protein 1; Has a role in the homologous recombination repair (HRR) of genomic DNA during meiosis. Required for rad-51 recruitment onto ssDNA gaps generated at stalled replication fork barriers. | 0.588 |
him-14 | rmh-1 | ZK1127.11.1 | M01E11.3.1 | MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair. | DUF1767 domain-containing protein. | 0.847 |