STRINGSTRING
ain-2 ain-2 ntl-2 ntl-2 exos-4.1 exos-4.1 ain-1 ain-1 crn-3 crn-3 crn-5 crn-5 tiar-1 tiar-1 hel-1 hel-1 C37H5.14 C37H5.14 smg-1 smg-1 skih-2 skih-2 F07H5.10 F07H5.10 F10E7.5 F10E7.5 smgl-1 smgl-1 exos-7 exos-7 panl-2 panl-2 F33D11.10 F33D11.10 exos-9 exos-9 ncbp-1 ncbp-1 lsm-1 lsm-1 exos-8 exos-8 rpb-4 rpb-4 patr-1 patr-1 tag-153 tag-153 smg-4 smg-4 disl-2 disl-2 dcap-2 dcap-2 dom-3 dom-3 let-711 let-711 exos-3 exos-3 smg-8 smg-8 parn-1 parn-1 M01G12.14 M01G12.14 M01G12.7 M01G12.7 M01G12.9 M01G12.9 rle-1 rle-1 edc-3 edc-3 rnp-4 rnp-4 mag-1 mag-1 pde-12 pde-12 pelo-1 pelo-1 prp-19 prp-19 eol-1 eol-1 smg-5 smg-5 W08E3.2 W08E3.2 dcs-1 dcs-1 smgl-2 smgl-2 xrn-1 xrn-1 Y44E3A.6 Y44E3A.6 tiar-2 tiar-2 ttc-37 ttc-37 Y47H10A.3 Y47H10A.3 Y47H10A.4 Y47H10A.4 Y47H10A.5 Y47H10A.5 xrn-2 xrn-2 smg-2 smg-2 rpb-7 rpb-7 smg-9 smg-9 smg-6 smg-6 dcap-1 dcap-1 ntl-3 ntl-3 ccf-1 ccf-1 exos-4.2 exos-4.2 smg-7 smg-7 smg-3 smg-3 exos-2 exos-2 ZC190.4 ZC190.4 ccr-4 ccr-4 panl-3 panl-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ain-2ALG-1 INteracting protein. (748 aa)
ntl-2NOT2_3_5 domain-containing protein. (444 aa)
exos-4.1Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events; Belongs to the RNase PH family. (240 aa)
ain-1ALG-1 INteracting protein. (641 aa)
crn-3HRDC domain-containing protein. (876 aa)
crn-5RNase_PH domain-containing protein. (214 aa)
tiar-1RRM domain-containing protein. (408 aa)
hel-1Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly. (425 aa)
C37H5.14RAI1 domain-containing protein. (322 aa)
smg-1Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2. (2322 aa)
skih-2SKI (Yeast SuperKIller) Helicase homolog. (1266 aa)
F07H5.10RAI1 domain-containing protein. (334 aa)
F10E7.5Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (220 aa)
smgl-1Uncharacterized protein. (1615 aa)
exos-7RNase_PH domain-containing protein. (312 aa)
panl-2Uncharacterized protein F31E3.4. (1131 aa)
F33D11.10Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa)
exos-9EXOSome (Multiexonuclease complex) component. (434 aa)
ncbp-1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa)
lsm-1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (125 aa)
exos-8RNase_PH domain-containing protein. (277 aa)
rpb-4RPOL4c domain-containing protein. (144 aa)
patr-1Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family. (833 aa)
tag-153NOT2_3_5 domain-containing protein. (733 aa)
smg-4Smg4_UPF3 domain-containing protein. (368 aa)
disl-2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (848 aa)
dcap-2mRNA-decapping enzyme 2; RNA-decapping enzyme although it does not bind cap. May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs. Belongs to the Nudix hydrolase family. DCP2 subfamily. (786 aa)
dom-3Decapping nuclease dom-3; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). (393 aa)
let-711Not1 domain-containing protein. (2641 aa)
exos-3KH_dom_type_1 domain-containing protein. (226 aa)
smg-8Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG8 family. (873 aa)
parn-13'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro. (566 aa)
M01G12.14Uncharacterized protein. (350 aa)
M01G12.7Uncharacterized protein. (460 aa)
M01G12.9Uncharacterized protein. (469 aa)
rle-1Regulation of longevity by E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance. Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection. (952 aa)
edc-3DFDF domain-containing protein. (566 aa)
rnp-4RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa)
mag-1Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family. (152 aa)
pde-12Endo/exonuclease/phosphatase domain-containing protein. (628 aa)
pelo-1Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity. (381 aa)
prp-19Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa)
eol-1RAI1 domain-containing protein. (316 aa)
smg-5Nonsense-mediated mRNA decay protein. (549 aa)
W08E3.2Btz domain-containing protein. (584 aa)
dcs-1m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decap [...] (311 aa)
smgl-2Uncharacterized protein. (1089 aa)
xrn-15'-3' exoribonuclease 1. (1591 aa)
Y44E3A.6FHA domain-containing protein. (843 aa)
tiar-2TIA-1/TIAL RNA binding protein homolog. (434 aa)
ttc-37TeTratriCopeptide repeat domain protein related. (1114 aa)
Y47H10A.3Uncharacterized protein. (333 aa)
Y47H10A.4Uncharacterized protein. (327 aa)
Y47H10A.5Uncharacterized protein. (331 aa)
xrn-25'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (975 aa)
smg-2Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity). (1069 aa)
rpb-7S1 motif domain-containing protein. (197 aa)
smg-9Protein smg-9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG9 family. (385 aa)
smg-6PINc domain-containing protein. (1241 aa)
dcap-1mRNA_decap_C domain-containing protein. (332 aa)
ntl-3NOT2_3_5 domain-containing protein. (701 aa)
ccf-1CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family. (310 aa)
exos-4.2RNase_PH domain-containing protein. (241 aa)
smg-7TPR_REGION domain-containing protein. (458 aa)
smg-3Suppressor with Morphological effect on Genitalia. (1144 aa)
exos-2EXOSome (Multiexonuclease complex) component. (303 aa)
ZC190.4SAM domain-containing protein. (629 aa)
ccr-4Endo/exonuclease/phosphatase domain-containing protein. (677 aa)
panl-3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (632 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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