STRINGSTRING
moe-3 moe-3 larp-5 larp-5 gla-3 gla-3 etr-1 etr-1 sup-26 sup-26 cdl-1 cdl-1 R05D3.8 R05D3.8 imph-1 imph-1 scbp-2 scbp-2 H28G03.1 H28G03.1 fbf-1 fbf-1 daz-1 daz-1 puf-5 puf-5 pos-1 pos-1 F39B2.3 F39B2.3 F38C2.7 F38C2.7 ccch-2 ccch-2 exc-7 exc-7 cpb-1 cpb-1 C35D6.4 C35D6.4 puf-8 puf-8 cpb-2 cpb-2 mma-1 mma-1 oma-1 oma-1 C04E6.11 C04E6.11 cpb-3 cpb-3 puf-7 puf-7 mex-6 mex-6 gld-1 gld-1 mex-5 mex-5 mex-1 mex-1 puf-9 puf-9 pab-1 pab-1 dct-13 dct-13 Y116A8C.19 Y116A8C.19 Y116A8C.20 Y116A8C.20 puf-3 puf-3 pie-1 pie-1 fog-1 fog-1 ccch-5 ccch-5 Y60A9.3 Y60A9.3 puf-11 puf-11 sqd-1 sqd-1 oma-2 oma-2 ncl-1 ncl-1 fbf-2 fbf-2 pab-2 pab-2 puf-6 puf-6 lin-28 lin-28
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
moe-3CCCH-type zinc finger protein moe-3; Zinc-finger protein that may play a role in oocyte maturation and fertility. (367 aa)
larp-5HTH La-type RNA-binding domain-containing protein. (760 aa)
gla-3Uncharacterized protein. (679 aa)
etr-1RRM domain-containing protein. (589 aa)
sup-26SUPpressor. (476 aa)
cdl-1Histone RNA hairpin-binding protein; Involved in histone pre-mRNA 3' processing. Required for chromosome condensation, progression of cell death and morphogenesis. (382 aa)
R05D3.8Putative RNA-binding protein R05D3.8. (311 aa)
imph-1IMP Homolog. (854 aa)
scbp-2Ribosomal_L7Ae domain-containing protein. (153 aa)
H28G03.1Uncharacterized protein. (336 aa)
fbf-1Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa)
daz-1DAZ protein 1; RNA-binding protein that plays a central role in oogenesis, but not for spermatogenesis. Required for meiotic entry and germline differentiation, at the pachytene stage of meiosis I of female germline regardless of the sex of the soma. May act by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR. (498 aa)
puf-5Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (553 aa)
pos-1Cytoplasmic zinc-finger protein. (264 aa)
F39B2.3PKS_ER domain-containing protein. (328 aa)
F38C2.7Uncharacterized protein. (203 aa)
ccch-2CCCH-type zinc finger putative transcription factor. (186 aa)
exc-7Uncharacterized protein. (456 aa)
cpb-1Cytoplasmic polyadenylation element-binding protein 1; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis. (560 aa)
C35D6.4Uncharacterized protein. (203 aa)
puf-8PUM-HD domain-containing protein. (535 aa)
cpb-2Cytoplasmic polyadenylation element-binding protein 2; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis. (570 aa)
mma-1Uncharacterized protein. (1058 aa)
oma-1CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] (407 aa)
C04E6.11Uncharacterized protein. (995 aa)
cpb-3Cytoplasmic polyadenylation element-binding protein 3; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). May not be required for oogenesis. (745 aa)
puf-7Pumilio domain-containing protein 7; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa)
mex-6Zinc finger protein mex-6; Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. (467 aa)
gld-1Female germline-specific tumor suppressor gld-1; RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pa [...] (463 aa)
mex-5Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. (468 aa)
mex-1Muscle EXcess. (494 aa)
puf-9PUM-HD domain-containing protein. (703 aa)
pab-1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (646 aa)
dct-13DAF-16/FOXO Controlled, germline Tumor affecting. (205 aa)
Y116A8C.19Uncharacterized protein. (196 aa)
Y116A8C.20Uncharacterized protein. (201 aa)
puf-3PUM-HD domain-containing protein. (502 aa)
pie-1Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex. (335 aa)
fog-1RRM domain-containing protein. (619 aa)
ccch-5CCCH-type zinc finger putative transcription factor. (199 aa)
Y60A9.3Uncharacterized protein. (203 aa)
puf-11PUM-HD domain-containing protein. (505 aa)
sqd-1Homologous to Drosophila SQD (Squid) protein. (308 aa)
oma-2CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa)
ncl-1B-box type zinc finger protein ncl-1; Translational repressor that inhibits protein synthesis. Represses the translation of mRNAs such as fib-1, probably by being recruited by RNA-binding protein nos-2 and the Pumilio proteins puf-5, puf-8 and puf-9 to the consensus core PUF binding motif in the 3'-UTR of fib-1 mRNA. Negatively regulates ribosomal RNA (rRNA) synthesis, ribosomal protein synthesis and nucleolus size. Its role in the negative regulation of nucleolus size is most likely through its negative regulation of the translation of proteins such as the rRNA 2'- O-methyltransferase [...] (982 aa)
fbf-2Fem-3 mRNA-binding factor 2; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR. Suppresses germline tumor formation by preventing the d [...] (632 aa)
pab-2Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (692 aa)
puf-6Pumilio domain-containing protein 6; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa)
lin-28Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. (227 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (18%) [HD]