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hum-6 hum-6 alp-1 alp-1 myo-2 myo-2 tni-3 tni-3 pat-6 pat-6 T24B8.4 T24B8.4 samp-1 samp-1 W02H5.2 W02H5.2 tni-4 tni-4 atn-1 atn-1 ttn-1 ttn-1 Y50D7A.10 Y50D7A.10 anc-1 anc-1 unc-27 unc-27 hipr-1 hipr-1 frm-1 frm-1 ZK1321.4 ZK1321.4 vab-10 vab-10 frg-1 frg-1 deb-1 deb-1 arx-3 arx-3 pod-1 pod-1 Y73B3B.1 Y73B3B.1 tln-1 tln-1 arx-1 arx-1 arx-4 arx-4 fln-1 fln-1 hum-8 hum-8 Y65B4A.4 Y65B4A.4 eps-8 eps-8 Y57G11C.22 Y57G11C.22 tag-273 tag-273 ipla-3 ipla-3 plst-1 plst-1 lev-11 lev-11 nmy-3 nmy-3 pfn-1 pfn-1 ctn-1 ctn-1 arx-5 arx-5 ddl-2 ddl-2 frl-1 frl-1 ani-1 ani-1 fli-1 fli-1 erm-1 erm-1 unc-78 unc-78 vps-16 vps-16 unc-94 unc-94 C07A9.5 C07A9.5 wsp-1 wsp-1 viln-1 viln-1 cas-2 cas-2 fln-2 fln-2 arx-6 arx-6 maph-1.3 maph-1.3 unc-60 unc-60 nab-1 nab-1 fhod-1 fhod-1 C46H11.3 C46H11.3 C50C3.2 C50C3.2 C50C3.5 C50C3.5 cap-1 cap-1 tag-138 tag-138 unc-87 unc-87 tth-1 tth-1 unc-115 unc-115 pes-7 pes-7 F09C6.1 F09C6.1 F10G8.8 F10G8.8 unc-54 unc-54 cyk-1 cyk-1 dys-1 dys-1 nlr-1 nlr-1 nmy-2 nmy-2 inx-3 inx-3 maph-1.2 maph-1.2 F26H9.2 F26H9.2 hum-1 hum-1 maph-1.1 maph-1.1 pfn-2 pfn-2 hum-2 hum-2 F36F2.1 F36F2.1 twf-2 twf-2 add-1 add-1 cas-1 cas-1 nfm-1 nfm-1 tni-1 tni-1 F42H10.3 F42H10.3 unc-53 unc-53 myo-6 myo-6 hum-4 hum-4 ipla-2 ipla-2 spe-15 spe-15 nmy-1 nmy-1 unc-60-2 unc-60-2 ketn-1 ketn-1 F54F2.7 F54F2.7 hum-7 hum-7 daam-1 daam-1 add-2 add-2 exc-6 exc-6 myo-5 myo-5 fozi-1 fozi-1 pfn-3 pfn-3 gsnl-1 gsnl-1 arx-2 arx-2 dbn-1 dbn-1 aipl-1 aipl-1 spc-1 spc-1 unc-70 unc-70 myo-3 myo-3 arx-7 arx-7 M04F3.5 M04F3.5 cap-2 cap-2 M116.5 M116.5 cor-1 cor-1 wve-1 wve-1 myo-1 myo-1 spe-26 spe-26 unc-9 unc-9 hmp-1 hmp-1 wip-1 wip-1 sma-1 sma-1 hum-5 hum-5 tag-243 tag-243
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (2098 aa)
alp-1ALP/Enigma encoding. (1424 aa)
myo-2Myosin-2; Muscle contraction. (1947 aa)
tni-3Troponin I 3; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (260 aa)
pat-6Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa)
T24B8.4Uncharacterized protein. (850 aa)
samp-1Transmembrane protein 201 homolog; Plays a role in nuclear migration in hypodermal cells. Belongs to the TMEM201 family. (588 aa)
W02H5.2Uncharacterized protein. (620 aa)
tni-4Troponin I 4; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (194 aa)
atn-1AcTiniN. (920 aa)
ttn-1Titin homolog; Serine/threonine-protein kinase. Key component in the assembly and functioning of muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase (By similarity). (15188 aa)
Y50D7A.10ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. GMF subfamily. (138 aa)
anc-1Nuclear anchorage protein 1; Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron. Belongs to the nesprin family. (8545 aa)
unc-27Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (242 aa)
hipr-1Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family. (927 aa)
frm-1FERM domain-containing protein. (4648 aa)
ZK1321.4PDZ domain-containing protein. (429 aa)
vab-10GAR domain-containing protein. (5059 aa)
frg-1Protein FRG1 homolog; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B (By similarity); Belongs to the FRG1 family. (274 aa)
deb-1Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa)
arx-3Actin-related protein 2/3 complex subunit. (375 aa)
pod-1Uncharacterized protein. (1136 aa)
Y73B3B.1Calponin-homology (CH) domain-containing protein. (376 aa)
tln-1Talin. (2553 aa)
arx-1Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (425 aa)
arx-4Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa)
fln-1Calponin-homology (CH) domain-containing protein. (2259 aa)
hum-8Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1279 aa)
Y65B4A.4Uncharacterized protein. (124 aa)
eps-8SH3 domain-containing protein. (942 aa)
Y57G11C.22Uncharacterized protein. (444 aa)
tag-273LIM zinc-binding domain-containing protein. (891 aa)
ipla-3Intracelllar PhosphoLipase A family. (1047 aa)
plst-1PLaSTin (Actin bundling protein) homolog. (370 aa)
lev-11Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa)
nmy-3Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1464 aa)
pfn-1Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. (132 aa)
ctn-1Alpha-CaTuliN (Catenin/vinculin related). (820 aa)
arx-5Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
ddl-2WASH_WAHD domain-containing protein. (497 aa)
frl-1FRL (Formin Related gene in Leukocytes) homolog. (1115 aa)
ani-1Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa)
fli-1Protein flightless-1 homolog; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. (1257 aa)
erm-1FERM domain-containing protein. (564 aa)
unc-78Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa)
vps-16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the la [...] (852 aa)
unc-94Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa)
C07A9.5Uncharacterized calcium-binding protein C07A9.5. (358 aa)
wsp-1WASP (Actin cytoskeleton modulator) homolog. (781 aa)
viln-1HP domain-containing protein. (918 aa)
cas-2Adenylyl cyclase-associated protein; Belongs to the CAP family. (457 aa)
fln-2FiLamiN (Actin binding protein) homolog. (3672 aa)
arx-6Probable actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (169 aa)
maph-1.3Microtubule-Associated Protein Homolog. (874 aa)
unc-60Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa)
nab-1NeurABin. (721 aa)
fhod-1Formin HOmology Domain. (1698 aa)
C46H11.3Probable actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (146 aa)
C50C3.2Uncharacterized protein C50C3.2; Belongs to the spectrin family. (2236 aa)
C50C3.5Uncharacterized calcium-binding protein C50C3.5. (189 aa)
cap-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
tag-138ENTH domain-containing protein. (362 aa)
unc-87Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa)
tth-1Thymosin beta; Plays an important role in the organization of the cytoskeleton by regulating actin polymerization in two ways. Firstly, by binding to and sequestering actin monomers (G actin) inhibits actin polymerization. Secondly, by binding directly filamentous actin (F actin) promotes actin polymerization. Regulates the formation of cortical actin in oocytes conferring them enough rigidity to sustain the contractions during ovulation. (151 aa)
unc-115Uncharacterized protein. (639 aa)
pes-7Patterned Expression Site. (1391 aa)
F09C6.1Uncharacterized protein. (226 aa)
F10G8.8Uncharacterized protein. (984 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
cyk-1CYtoKinesis defect. (1437 aa)
dys-1Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa)
nlr-1Neurexin Like receptor. (1180 aa)
nmy-2Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2003 aa)
inx-3Innexin-3; Structural component of the gap junctions. Belongs to the pannexin family. (420 aa)
maph-1.2Microtubule-Associated Protein Homolog. (874 aa)
F26H9.2Uncharacterized protein. (508 aa)
hum-1Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1100 aa)
maph-1.1Microtubule-associated protein homolog maph-1.1; Belongs to the MAP1A/MAP1B/MAP1S family. (878 aa)
pfn-2Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (131 aa)
hum-2Dilute domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1811 aa)
F36F2.1Costars domain-containing protein. (162 aa)
twf-2TWinFilin actin binding protein homolog. (333 aa)
add-1Adducin-related protein 1; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. (732 aa)
cas-1Adenylyl cyclase-associated protein; Belongs to the CAP family. (1256 aa)
nfm-1FERM domain-containing protein. (709 aa)
tni-1Troponin I 1; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (250 aa)
F42H10.3LIM and SH3 domain protein F42H10.3. (335 aa)
unc-53Adapter protein unc-53; Involved in the migration and outgrowth of muscles, axons and excretory canals. (1654 aa)
myo-6Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1235 aa)
hum-4Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2581 aa)
ipla-2Intracelllar PhosphoLipase A family. (1071 aa)
spe-15Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1219 aa)
nmy-1Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
unc-60-2Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa)
ketn-1KETtiN (Drosophila actin-binding) homolog. (4963 aa)
F54F2.7Uncharacterized protein F54F2.7. (157 aa)
hum-7Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa)
daam-1FH2 domain-containing protein. (987 aa)
add-2Adducin-related protein 2; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network; Belongs to the aldolase class II family. Adducin subfamily. (611 aa)
exc-6Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa)
myo-5MYOsin heavy chain structural genes; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
fozi-1Formin-homology and zinc finger domains protein 1; Acts redundantly with hlh-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2; Belongs to the formin homology family. (732 aa)
pfn-3Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. (126 aa)
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. (475 aa)
arx-2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (395 aa)
dbn-1Drebrin-like protein. (643 aa)
aipl-1WD_REPEATS_REGION domain-containing protein. (600 aa)
spc-1SPeCtrin. (2432 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2326 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
arx-7Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
M04F3.5IMD domain-containing protein. (655 aa)
cap-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa)
M116.5Uncharacterized protein. (1020 aa)
cor-1Coronin-like protein cor-1; Required to direct the migration of Q neuroblasts along the anterior axis of the body during larval development. This is dependent on its asymmetric expression in Q neuroblasts. Belongs to the WD repeat coronin family. (607 aa)
wve-1WH2 domain-containing protein. (468 aa)
myo-1Myosin-1; Muscle contraction. (1938 aa)
spe-26Spermatocyte protein spe-26; May play a role in the spermatocyte cytoskeleton, possibly interacting with actin. (570 aa)
unc-9Innexin unc-9; Structural component of the gap junctions. Belongs to the pannexin family. (386 aa)
hmp-1Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family. (930 aa)
wip-1WH2 domain-containing protein. (362 aa)
sma-1SMAll. (4166 aa)
hum-5Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1017 aa)
tag-243Costars domain-containing protein. (240 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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