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| | nas-14 | Zinc metalloproteinase nas-14; Metalloprotease. (503 aa) |
| | clpp-1 | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. (221 aa) |
| | nep-26 | NEPrilysin metallopeptidase family. (807 aa) |
| | ZK930.6 | Lon proteolytic domain-containing protein. (206 aa) |
| | atg-4.2 | Cysteine protease atg-4.2; Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.1, but it cleaves lgg-1 precursors less efficiently than atg-4.1 (Probable). In contrast to atg-4.1, plays a more significant role in the later phases of autophagy and [...] (521 aa) |
| | ZK550.3 | Peptidase_M3 domain-containing protein. (772 aa) |
| | try-1 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (293 aa) |
| | spe-4 | Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa) |
| | ZK430.5 | Peptidase C50 domain-containing protein. (1276 aa) |
| | asp-19 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (223 aa) |
| | asp-18 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (392 aa) |
| | nep-1 | Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family. (754 aa) |
| | adm-4 | Disintegrin and metalloproteinase domain-containing protein 17 homolog; Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision. By modulating lin-12/Notch signaling, plays a role in germline development. (686 aa) |
| | nep-25 | Peptidase_M13 domain-containing protein. (515 aa) |
| | try-7 | Peptidase S1 domain-containing protein. (380 aa) |
| | mppb-1 | Mitochondrial-processing peptidase subunit beta; Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2 (Probable). (458 aa) |
| | nas-30 | Zinc metalloproteinase nas-30; Metalloprotease. (525 aa) |
| | atg-4.1 | Cysteine protease atg-4.1; Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.2, but it cleaves lgg-1 precursors more efficiently than atg-4.2 (Probable). Acts redundantly with atg-4.2 to promote the lgg-1 delipidation to release the protein fro [...] (481 aa) |
| | clp-7 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (778 aa) |
| | clp-6 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (627 aa) |
| | lonp-2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. (773 aa) |
| | csp-2 | Putative inactive caspase B subunit p17; [Isoform b]: Putative inactive caspase. In the germline, binds caspase ced-3 zymogen and prevents ced-3 autoactivation. Does not affect the caspase activity of mature ced-3 and ced-4-mediated mature ced-3 activation. Negatively regulates germline apoptosis by inhibiting autocleavage of caspase ced-3. Involved in fertility ; Belongs to the peptidase C14A family. (826 aa) |
| | Y71H2AR.2 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (345 aa) |
| | Y71H2AM.25 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa) |
| | Y70C5C.1 | Uncharacterized protein; Belongs to the peptidase M16 family. (985 aa) |
| | Y67H2A.7 | Peptidase_M3 domain-containing protein. (692 aa) |
| | Y67D2.2 | Ubiquitin carboxyl-terminal hydrolase. (474 aa) |
| | Y65B4A.2 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (448 aa) |
| | pqn-87 | MATH domain-containing protein. (1485 aa) |
| | Y56A3A.2 | Peptidase_M50 domain-containing protein. (616 aa) |
| | immp-2 | Inner Mitochondrial Membrane Protease. (152 aa) |
| | Y54E10BR.5 | Signal peptidase complex catalytic subunit SEC11. (183 aa) |
| | rom-5 | Rhomboid domain-containing protein. (325 aa) |
| | clpr-4 | CaLPain Related. (308 aa) |
| | Y51A2D.8 | Uncharacterized protein; Belongs to the peptidase C1 family. (386 aa) |
| | Y51A2D.1 | Uncharacterized protein; Belongs to the peptidase C1 family. (314 aa) |
| | Y50D7A.13 | ZnMc domain-containing protein. (194 aa) |
| | csp-1 | Caspase A subunit p14; Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels. (536 aa) |
| | csp-3 | Non-catalytic caspase homolog csp-3; Non-catalytic caspase homolog which does not contain the region necessary for caspase activity. Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4- induced ced-3 processing. Has no effect on active ced-3. Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development ; Belongs to the peptidase C14A family. (139 aa) |
| | clp-3 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (752 aa) |
| | sep-1 | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] (1262 aa) |
| | spg-7 | AFG3-like protein spg-7; Acts as a component of the m-AAA protease complex which is an ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins (By similarity). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (By similarity). Functions both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides. Plays a role in male tail tip morphogenesis. In the C-terminal section; belongs to the peptidase M41 family. (782 aa) |
| | Y47C4A.1 | Uncharacterized protein. (408 aa) |
| | Y43F4A.1 | Leishmanolysin-like peptidase; Essential for the coordination of mitotic progression, and also plays a role in cell migration. (663 aa) |
| | Y40H7A.10 | Uncharacterized protein; Belongs to the peptidase C1 family. (343 aa) |
| | asp-17 | Aspartic protease 17; Aspartic proteinase; Belongs to the peptidase A1 family. (391 aa) |
| | asp-16 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa) |
| | asp-15 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa) |
| | asp-1 | Aspartic protease 1; Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis ; Belongs to the peptidase A1 family. (396 aa) |
| | clp-4 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (716 aa) |
| | ppgn-1 | AAA domain-containing protein. (747 aa) |
| | unc-71 | Disintegrin and metalloproteinase domain-containing protein unc-71; Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development. Involved in axon branching and guidance of neurons including GABAergic type D motor neurons. Promotes sex myoblast migration and positioning independently of gonad attraction cues. May act downstream of mig-13 in order to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis. Required for coordinated movements. (1042 aa) |
| | Y19D10A.6 | Metalloendopeptidase. (272 aa) |
| | nep-24 | NEPrilysin metallopeptidase family. (567 aa) |
| | nep-23 | NEPrilysin metallopeptidase family. (714 aa) |
| | rom-4 | Rhomboid domain-containing protein. (1205 aa) |
| | rom-3 | Rhomboid domain-containing protein. (861 aa) |
| | Y113G7B.15 | Uncharacterized protein; Belongs to the peptidase C1 family. (362 aa) |
| | zmp-4 | ZnMc domain-containing protein. (472 aa) |
| | cpr-5 | Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa) |
| | W07B8.4 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa) |
| | cpr-8 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa) |
| | clp-10 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (634 aa) |
| | clpr-1 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (252 aa) |
| | W01F3.2 | Uncharacterized protein. (307 aa) |
| | ucr-2.1 | Ubiquinol-Cytochrome c oxidoReductase complex. (424 aa) |
| | T28H10.3 | Uncharacterized protein. (462 aa) |
| | usp-5 | Ubiquitin carboxyl-terminal hydrolase. (789 aa) |
| | nep-22 | NEPrilysin metallopeptidase family. (798 aa) |
| | ucr-2.3 | Peptidase_M16 domain-containing protein. (427 aa) |
| | T24B8.7 | Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (2938 aa) |
| | toh-1 | Zinc metalloproteinase nas-26; Metalloprotease. (414 aa) |
| | nas-5 | Zinc metalloproteinase nas-5; Metalloprotease. (360 aa) |
| | T23G4.2 | Lon proteolytic domain-containing protein. (101 aa) |
| | nas-27 | Zinc metalloproteinase nas-27; Metalloprotease. (428 aa) |
| | T22F3.2 | USP domain-containing protein. (393 aa) |
| | T21E12.3 | Peptidase S1 domain-containing protein. (346 aa) |
| | zmp-6 | ZnMc domain-containing protein. (279 aa) |
| | pbs-4 | Proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (202 aa) |
| | adt-3 | Peptidase M12B domain-containing protein. (940 aa) |
| | dvc-1 | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: required to protect genome stability during DNA replication, possibly via recruitment of vcp/p97 (cdc-48.1 or cdc-48.2) recruitment. Belongs to the Spartan family. (368 aa) |
| | asp-2 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (429 aa) |
| | nep-21 | Neprilysin-21; Probable cell surface protease. (856 aa) |
| | T13B5.9 | Uncharacterized protein. (378 aa) |
| | nas-22 | Zinc metalloproteinase nas-22; Metalloprotease. (367 aa) |
| | nas-21 | Zinc metalloproteinase-like protein nas-21; May lack metalloprotease activity. (380 aa) |
| | nas-20 | Zinc metalloproteinase nas-20; Metalloprotease. (379 aa) |
| | clp-9 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (718 aa) |
| | cpr-3 | Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa) |
| | ucr-2.2 | Ubiquinol-Cytochrome c oxidoReductase complex. (422 aa) |
| | nep-20 | NEPrilysin metallopeptidase family. (834 aa) |
| | T05H10.1 | USP domain-containing protein; Belongs to the peptidase C19 family. (1326 aa) |
| | hpo-4 | Putative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family. (319 aa) |
| | imp-2 | Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. (468 aa) |
| | nep-2 | Neprilysin-2; Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. (736 aa) |
| | nas-15 | Zinc metalloproteinase nas-15; Metalloprotease. (571 aa) |
| | clp-2 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (805 aa) |
| | cpl-1 | Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa) |
| | nas-32 | Zinc metalloproteinase nas-32; Metalloprotease. (653 aa) |
| | dpy-31 | Zinc metalloproteinase dpy-31; Metalloprotease which cleaves the carboxyl terminus of procollagens, such as sqt-3, to mature collagens (By similarity). Involved in cuticular collagen maturation. (592 aa) |
| | R13H4.6 | Lon proteolytic domain-containing protein. (265 aa) |
| | asp-4 | Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa) |
| | dpf-5 | Peptidase_S9 domain-containing protein. (737 aa) |
| | dpf-7 | Dipeptidyl Peptidase Four (IV) family. (643 aa) |
| | nas-23 | Zinc metalloproteinase nas-23; Metalloprotease. (537 aa) |
| | usp-46 | Ubiquitin carboxyl-terminal hydrolase 46; Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity. (426 aa) |
| | R09F10.1 | Uncharacterized protein; Belongs to the peptidase C1 family. (383 aa) |
| | R07E3.1 | Uncharacterized protein; Belongs to the peptidase C1 family. (402 aa) |
| | cpz-2 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (467 aa) |
| | ymel-1 | ATP-dependent zinc metalloprotease YME1 homolog; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function (By similarity); In the C-terminal section; belongs to the peptidase M41 family. (723 aa) |
| | tra-3 | Calpain-5; Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis. Part of the necrosis cell death pathway. Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa ; Belongs to the peptidase C2 family. (648 aa) |
| | nas-11 | Zinc metalloproteinase nas-11; Metalloprotease. (579 aa) |
| | asp-14 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa) |
| | nas-10 | Zinc metalloproteinase nas-10; Metalloprotease. (560 aa) |
| | usp-33 | Ubiquitin carboxyl-terminal hydrolase. (716 aa) |
| | pbs-1 | Proteasome subunit beta. (242 aa) |
| | try-5 | Trypsin-like protease try-5; Serine protease which, in males, acts as a promoting signal during mating to activate sperm. (327 aa) |
| | nas-3 | Zinc metalloproteinase nas-3; Metalloprotease. (292 aa) |
| | pbs-5 | Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa) |
| | bli-4 | Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development. (942 aa) |
| | nas-33 | Zinc metalloproteinase nas-33; Metalloprotease. (644 aa) |
| | K03B8.6 | Uncharacterized protein. (331 aa) |
| | nas-19 | Zinc metalloproteinase nas-19; Metalloprotease. (396 aa) |
| | nas-18 | Zinc metalloproteinase nas-18; Metalloprotease. (240 aa) |
| | nas-17 | Zinc metalloproteinase nas-17; Metalloprotease. (448 aa) |
| | nas-16 | Zinc metalloproteinase nas-16; Metalloprotease. (337 aa) |
| | nep-18 | NEPrilysin metallopeptidase family. (701 aa) |
| | K02E7.10 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa) |
| | K02C4.3 | Probable ubiquitin carboxyl-terminal hydrolase K02C4.3. (1261 aa) |
| | tasp-1 | TASPase homolog. (331 aa) |
| | zmp-5 | ZnMc domain-containing protein. (405 aa) |
| | clpr-3 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (308 aa) |
| | asp-3 | Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa) |
| | math-33 | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1138 aa) |
| | zmp-2 | Matrix metalloproteinase-B; Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol. (519 aa) |
| | asp-8 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (386 aa) |
| | asp-7 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (380 aa) |
| | nas-31 | Zinc metalloproteinase nas-31; Metalloprotease. (611 aa) |
| | nas-29 | Zinc metalloproteinase nas-29; Metalloprotease. (532 aa) |
| | F57F5.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa) |
| | nas-38 | Zinc metalloproteinase nas-38; Metalloprotease. (745 aa) |
| | mig-17 | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] (509 aa) |
| | nas-2 | Zinc metalloproteinase nas-2; Metalloprotease. (272 aa) |
| | nep-17 | NEPrilysin metallopeptidase family. (1589 aa) |
| | madd-4 | Protein madd-4; Component of an extracellular matrix cue that is involved in the guidance of dorsoventral midline migrations and in the specification of postsynaptic domains at neuromuscular junctions (NMJs). Acts as a ligand for the netrin receptor unc-40 and the neuroligin receptor nlg-1. Secreted by the dorsal and ventral nerve cords to attract sensory axons and muscle membrane extensions called muscle arms. In parallel with unc-6 and slt-1, involved in the netrin receptor unc-40 dependent guidance of the AVM and PVM mechanosensory axons along the dorsal-ventral axis. The unc-40 cor [...] (1045 aa) |
| | fce-2 | CAAX prenyl protease 2 homolog; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family. (266 aa) |
| | F48E3.4 | Peptidase S1 domain-containing protein. (279 aa) |
| | try-6 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (343 aa) |
| | clpr-2 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (502 aa) |
| | F46F5.5 | Lon proteolytic domain-containing protein. (322 aa) |
| | nas-25 | Zinc metalloproteinase nas-25; Metalloprotease. (399 aa) |
| | grd-2 | GRounDhog (Hedgehog-like family). (946 aa) |
| | bli-5 | Kunitz-type protein bli-5; Appears to lack serine protease inhibitor activity in vitro when tested with bovine pancreatic alpha-chymotrypsin and elastase. Involved in cuticle biosynthesis. (202 aa) |
| | nas-1 | Zinc metalloproteinase nas-1; Metalloprotease. (270 aa) |
| | nep-16 | Peptidase_M13_N domain-containing protein. (868 aa) |
| | clp-8 | Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (646 aa) |
| | F44E7.4 | Uncharacterized protein; Belongs to the peptidase M16 family. (1067 aa) |
| | cpr-4 | Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa) |
| | nas-28 | Zinc metalloproteinase nas-28; Metalloprotease. (497 aa) |
| | tag-196 | Uncharacterized protein; Belongs to the peptidase C1 family. (477 aa) |
| | F41C6.4 | Uncharacterized protein. (393 aa) |
| | hch-1 | Zinc metalloproteinase nas-34; Metalloprotease (By similarity). Required for normal hatching and migration of neuroblasts. May act by degrading eggshell proteins at hatching. (605 aa) |
| | nep-15 | Peptidase_M13 domain-containing protein. (267 aa) |
| | pbs-7 | Proteasome subunit beta; Belongs to the peptidase T1B family. (236 aa) |
| | nep-13 | NEPrilysin metallopeptidase family. (732 aa) |
| | nas-13 | Zinc metalloproteinase nas-13; Metalloprotease. (450 aa) |
| | nas-39 | Zinc metalloproteinase nas-39; Metalloprotease. (951 aa) |
| | cpr-2 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa) |
| | sel-12 | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa) |
| | F32H5.1 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa) |
| | cpz-1 | Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa) |
| | aex-5 | Endoprotease aex-5; Probable serine endoprotease which cleaves preproteins at paired basic amino acids. May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, required for fatty acid uptake by intestinal cell [...] (537 aa) |
| | try-4 | Peptidase S1 domain-containing protein. (324 aa) |
| | usp-48 | Ubiquitin carboxyl-terminal hydrolase usp-48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression ; Belongs to the peptidase C19 family. (1262 aa) |
| | asp-13 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (389 aa) |
| | F27D9.7 | Peptidase M12B domain-containing protein. (386 aa) |
| | nep-12 | NEPrilysin metallopeptidase family. (734 aa) |
| | rom-1 | Rhomboid-related protein 1; Serine protease which activates lin-3 isoform a in the proximal vulva precursor cells (VPC) during vulva development to transmit the inductive anchor cell signal to the distal VPCs. (356 aa) |
| | gon-1 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] (2165 aa) |
| | try-8 | Peptidase S1 domain-containing protein. (401 aa) |
| | tpp-2 | Tripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Has a role in regulation of fat storage; Belongs to the peptidase S8 family. (1374 aa) |
| | asp-6 | Aspartic protease 6; Aspartic protease; Belongs to the peptidase A1 family. (389 aa) |
| | asp-12 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa) |
| | asp-5 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (393 aa) |
| | nas-24 | Zinc metalloproteinase nas-24; Metalloprotease. (396 aa) |
| | F19B2.7 | Lon proteolytic domain-containing protein. (259 aa) |
| | nep-11 | Neprilysin-11; Probable cell surface protease; Belongs to the peptidase M13 family. (848 aa) |
| | nep-10 | NEPrilysin metallopeptidase family. (711 aa) |
| | nep-9 | NEPrilysin metallopeptidase family. (700 aa) |
| | nep-8 | Peptidase_M13 domain-containing protein. (686 aa) |
| | nep-6 | NEPrilysin metallopeptidase family. (726 aa) |
| | F15D4.4 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (608 aa) |
| | try-10 | Peptidase S1 domain-containing protein. (355 aa) |
| | nep-5 | NEPrilysin metallopeptidase family. (655 aa) |
| | kpc-1 | Furin-like protease kpc-1; Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-t [...] (692 aa) |
| | adt-2 | A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development. (1020 aa) |
| | zmp-1 | Matrix metalloproteinase-A; Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium. (521 aa) |
| | sup-17 | Disintegrin and metalloproteinase domain-containing protein 10 homolog; Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification. By modulating lin-12/Notch signaling, plays a role in germline development. Probably by modulating BMP-like Sma/Mab signaling via the shedding of unc-40 ectodomain, involved in the regulation of body size and mesoderm development. Probably b [...] (922 aa) |
| | nep-4 | Peptidase_M13 domain-containing protein. (437 aa) |
| | cpr-1 | Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa) |
| | egl-3 | Neuroendocrine convertase 2; Serine endoprotease which cleaves preproteins at paired basic amino acids. Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit. Regulates sensitivity to mechanosensory stimuli. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Probably by processing flp neuropeptides, regulates the turning step of male mating behavior. [...] (652 aa) |
| | tag-329 | Uncharacterized protein; Belongs to the peptidase C1 family. (374 aa) |
| | nep-3 | NEPrilysin metallopeptidase family. (634 aa) |
| | ced-3 | Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa) |
| | rom-2 | Inactive rhomboid-related protein 2; Probable inactive serine protease. (435 aa) |
| | pbs-2 | Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa) |
| | try-3 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (313 aa) |
| | nas-9 | Zinc metalloproteinase nas-9; Metalloprotease. (546 aa) |
| | mig-6 | Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo. (2167 aa) |
| | imp-1 | IntraMembrane Protease (IMPAS) family. (662 aa) |
| | tag-275 | Peptidase M12B domain-containing protein. (472 aa) |
| | nas-8 | Zinc metalloproteinase nas-8; Metalloprotease. (403 aa) |
| | lonp-1 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mi [...] (971 aa) |
| | imp-3 | IntraMembrane Protease (IMPAS) family. (530 aa) |
| | C32B5.7 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (234 aa) |
| | C32B5.13 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (150 aa) |
| | zmp-3 | Matrix metalloproteinase-C; Metalloproteinase. (579 aa) |
| | C28F5.4 | Putative zinc protease C28F5.4; Belongs to the peptidase M16 family. (856 aa) |
| | nas-36 | Zinc metalloproteinase nas-36; Metalloprotease (By similarity). Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. (617 aa) |
| | cpr-6 | Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa) |
| | immp-1 | Peptidase_S24 domain-containing protein. (132 aa) |
| | nas-12 | Zinc metalloproteinase nas-12; Metalloprotease. (384 aa) |
| | hop-1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa) |
| | nas-37 | Zinc metalloproteinase nas-37; Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Required during ecdysis, the opening of the cuticle to allow the worm to escape. (765 aa) |
| | hrg-7 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (428 aa) |
| | asp-9 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa) |
| | svh-1 | Serine protease svh-1; Serine protease which ensures proper pharyngeal pumping during larval growth by regulating the levels of extracellular matrix component fbl-1. Independently of its enzymatic activity and probably by acting as a ligand for tyrosine-protein kinase receptor svh-2, involved in axon regeneration after injury by promoting the generation of productive and stable growth cones. May play a role in gonad development. (951 aa) |
| | nas-7 | Zinc metalloproteinase nas-7; Metalloprotease. (382 aa) |
| | clp-1 | Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death. (780 aa) |
| | C06C3.8 | Lon proteolytic domain-containing protein. (579 aa) |
| | C05G5.5 | Metalloprotease TIKI homolog; Metalloprotease; Belongs to the TIKI family. (420 aa) |
| | nas-4 | Zinc metalloproteinase nas-4; Metalloprotease (By similarity). May be involved in digestion. (365 aa) |
| | C05D11.1 | Uncharacterized protein C05D11.1. (995 aa) |
| | fce-1 | CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (442 aa) |
| | adm-2 | ADAM (Disintegrin plus metalloprotease) family. (952 aa) |
| | C02G6.2 | Uncharacterized protein; Belongs to the peptidase M16 family. (816 aa) |
| | pbs-6 | Proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (258 aa) |
| | adt-1 | A disintegrin and metalloproteinase with thrombospondin motifs adt-1; Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle. (1461 aa) |
| | ddi-1 | Protein DDI1 homolog 1; Aspartic protease. Required for the cleavage and activation of transcription factors such as isoform a of the transcription factor skn-1, which in turn regulates the expression of proteasomal subunits such as rpt-3; Belongs to the DDI1 family. (389 aa) |
| | csn-5 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] (368 aa) |
| | lat-1 | Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. (1014 aa) |
| | try-9 | Peptidase S1 domain-containing protein. (279 aa) |
| | lat-2 | Latrophilin-like protein LAT-2; May have a role in pharyngeal pumping during feeding. (1338 aa) |
| | nas-6 | Zinc metalloproteinase nas-6; Metalloprotease. (344 aa) |
