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clp-1 clp-1 cpr-6 cpr-6 C32B5.13 C32B5.13 C32B5.7 C32B5.7 ced-3 ced-3 tag-329 tag-329 cpr-1 cpr-1 F15D4.4 F15D4.4 usp-48 usp-48 cpz-1 cpz-1 F32H5.1 F32H5.1 cpr-2 cpr-2 tag-196 tag-196 cpr-4 cpr-4 clp-8 clp-8 clpr-2 clpr-2 fce-2 fce-2 F57F5.1 F57F5.1 math-33 math-33 clpr-3 clpr-3 K02C4.3 K02C4.3 K02E7.10 K02E7.10 usp-33 usp-33 tra-3 tra-3 atg-4.2 atg-4.2 cpz-2 cpz-2 R07E3.1 R07E3.1 R09F10.1 R09F10.1 usp-46 usp-46 cpl-1 cpl-1 clp-2 clp-2 hpo-4 hpo-4 T05H10.1 T05H10.1 cpr-3 cpr-3 clp-9 clp-9 T22F3.2 T22F3.2 T24B8.7 T24B8.7 usp-5 usp-5 T28H10.3 T28H10.3 clpr-1 clpr-1 clp-10 clp-10 cpr-8 cpr-8 W07B8.4 W07B8.4 cpr-5 cpr-5 ZK430.5 ZK430.5 Y113G7B.15 Y113G7B.15 clp-4 clp-4 Y40H7A.10 Y40H7A.10 sep-1 sep-1 clp-3 clp-3 csp-3 csp-3 csp-1 csp-1 Y51A2D.1 Y51A2D.1 Y51A2D.8 Y51A2D.8 clpr-4 clpr-4 pqn-87 pqn-87 Y65B4A.2 Y65B4A.2 Y67D2.2 Y67D2.2 Y71H2AM.25 Y71H2AM.25 Y71H2AR.2 Y71H2AR.2 csp-2 csp-2 clp-6 clp-6 clp-7 clp-7 atg-4.1 atg-4.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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clp-1Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death. (780 aa)
cpr-6Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
C32B5.13Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (150 aa)
C32B5.7Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (234 aa)
ced-3Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa)
tag-329Uncharacterized protein; Belongs to the peptidase C1 family. (374 aa)
cpr-1Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
F15D4.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (608 aa)
usp-48Ubiquitin carboxyl-terminal hydrolase usp-48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression ; Belongs to the peptidase C19 family. (1262 aa)
cpz-1Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa)
F32H5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
cpr-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
tag-196Uncharacterized protein; Belongs to the peptidase C1 family. (477 aa)
cpr-4Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
clp-8Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (646 aa)
clpr-2Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (502 aa)
fce-2CAAX prenyl protease 2 homolog; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family. (266 aa)
F57F5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
math-33Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1138 aa)
clpr-3Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (308 aa)
K02C4.3Probable ubiquitin carboxyl-terminal hydrolase K02C4.3. (1261 aa)
K02E7.10Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa)
usp-33Ubiquitin carboxyl-terminal hydrolase. (716 aa)
tra-3Calpain-5; Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis. Part of the necrosis cell death pathway. Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa ; Belongs to the peptidase C2 family. (648 aa)
atg-4.2Cysteine protease atg-4.2; Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.1, but it cleaves lgg-1 precursors less efficiently than atg-4.1 (Probable). In contrast to atg-4.1, plays a more significant role in the later phases of autophagy and [...] (521 aa)
cpz-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (467 aa)
R07E3.1Uncharacterized protein; Belongs to the peptidase C1 family. (402 aa)
R09F10.1Uncharacterized protein; Belongs to the peptidase C1 family. (383 aa)
usp-46Ubiquitin carboxyl-terminal hydrolase 46; Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity. (426 aa)
cpl-1Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa)
clp-2Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (805 aa)
hpo-4Putative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family. (319 aa)
T05H10.1USP domain-containing protein; Belongs to the peptidase C19 family. (1326 aa)
cpr-3Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
clp-9Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (718 aa)
T22F3.2USP domain-containing protein. (393 aa)
T24B8.7Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (2938 aa)
usp-5Ubiquitin carboxyl-terminal hydrolase. (789 aa)
T28H10.3Uncharacterized protein. (462 aa)
clpr-1Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (252 aa)
clp-10Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (634 aa)
cpr-8Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
W07B8.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
cpr-5Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
ZK430.5Peptidase C50 domain-containing protein. (1276 aa)
Y113G7B.15Uncharacterized protein; Belongs to the peptidase C1 family. (362 aa)
clp-4Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (716 aa)
Y40H7A.10Uncharacterized protein; Belongs to the peptidase C1 family. (343 aa)
sep-1Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] (1262 aa)
clp-3Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (752 aa)
csp-3Non-catalytic caspase homolog csp-3; Non-catalytic caspase homolog which does not contain the region necessary for caspase activity. Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4- induced ced-3 processing. Has no effect on active ced-3. Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development ; Belongs to the peptidase C14A family. (139 aa)
csp-1Caspase A subunit p14; Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels. (536 aa)
Y51A2D.1Uncharacterized protein; Belongs to the peptidase C1 family. (314 aa)
Y51A2D.8Uncharacterized protein; Belongs to the peptidase C1 family. (386 aa)
clpr-4CaLPain Related. (308 aa)
pqn-87MATH domain-containing protein. (1485 aa)
Y65B4A.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (448 aa)
Y67D2.2Ubiquitin carboxyl-terminal hydrolase. (474 aa)
Y71H2AM.25Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa)
Y71H2AR.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (345 aa)
csp-2Putative inactive caspase B subunit p17; [Isoform b]: Putative inactive caspase. In the germline, binds caspase ced-3 zymogen and prevents ced-3 autoactivation. Does not affect the caspase activity of mature ced-3 and ced-4-mediated mature ced-3 activation. Negatively regulates germline apoptosis by inhibiting autocleavage of caspase ced-3. Involved in fertility ; Belongs to the peptidase C14A family. (826 aa)
clp-6Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (627 aa)
clp-7Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (778 aa)
atg-4.1Cysteine protease atg-4.1; Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.2, but it cleaves lgg-1 precursors more efficiently than atg-4.2 (Probable). Acts redundantly with atg-4.2 to promote the lgg-1 delipidation to release the protein fro [...] (481 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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