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| | gsp-1 | Serine/threonine-protein phosphatase PP1-alpha; Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Dephosphorylates translation initiation factor eIF2alpha. Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Belongs to the PPP phosphatase family. PP-1 subfamily. (329 aa) |
| | fcp-1 | RNA polymerase II subunit A C-terminal domain phosphatase; During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1. Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage. May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells. (659 aa) |
| | let-92 | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] (318 aa) |
| | gsp-4 | Serine/threonine-protein phosphatase PP1-delta; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium. (305 aa) |
| | daf-18 | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] (962 aa) |
| | ssup-72 | RNA polymerase II subunit A C-terminal domain phosphatase ssup-72; Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1. By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre- mRNAs, including unc-44 and dlk-1 mRNAs. This results in the tissue-specific expression of unc-44 isoforms. (197 aa) |
| | T16G12.7 | Serine/threonine-protein phosphatase. (319 aa) |
| | fem-2 | Protein phosphatase fem-2; Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin- dependent protein kinase unc-43/CAMKII in vitro. Involved in the regulation of sex determination. Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes. Promotes apoptosis. Belongs to the PP2C family. (449 aa) |
| | oga-1 | O-GlcNAc selective N-Acetyl-beta-D-glucosaminidase (O-GlcNAcase). (872 aa) |
| | ppm-2 | Probable protein phosphatase 2C T23F11.1. (356 aa) |
| | T25B9.2 | Serine/threonine-protein phosphatase. (343 aa) |
| | W03D8.2 | Serine/threonine-protein phosphatase. (364 aa) |
| | W04A8.1 | Uncharacterized protein. (667 aa) |
| | gsp-3 | Serine/threonine-protein phosphatase PP1-gamma; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium. (305 aa) |
| | W09D10.4 | Protein phosphatase; Belongs to the PP2C family. (330 aa) |
| | pph-5 | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase. Dephosphorylates cdc-37. Probably by dephosphorylating separase sep-1, may be involved in sep-1-mediated exocytosis of cortical granules during meiotic anaphase and mitotic cytokinesis. (496 aa) |
| | Y40H4A.2 | SER_THR_PHOSPHATASE domain-containing protein. (333 aa) |
| | pph-4.2 | Serine/threonine-protein phosphatase 4 catalytic subunit 2; Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis. (321 aa) |
| | ppm-1.D | PPM-type phosphatase domain-containing protein. (766 aa) |
| | Y69E1A.4 | Serine/threonine-protein phosphatase. (375 aa) |
| | Y71G12B.30 | Serine/threonine-protein phosphatase. (333 aa) |
| | pph-4.1 | Serine/threonine-protein phosphatase 4 catalytic subunit 1; Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis. During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM). During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulti [...] (333 aa) |
| | ZC477.2 | SER_THR_PHOSPHATASE domain-containing protein. (374 aa) |
| | ZK354.9 | Serine/threonine-protein phosphatase. (296 aa) |
| | ZK938.1 | Serine/threonine-protein phosphatase. (327 aa) |
| | pdp-1 | PPM-type phosphatase domain-containing protein. (451 aa) |
| | scpl-1 | CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. (491 aa) |
| | tax-6 | Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...] (545 aa) |
| | pph-1 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (349 aa) |
| | lip-1 | Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | C06A1.3 | Putative serine/threonine-protein phosphatase C06A1.3. (364 aa) |
| | C09H5.7 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa) |
| | cdc-14 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] (709 aa) |
| | C23G10.1 | Putative serine/threonine-protein phosphatase C23G10.1. (456 aa) |
| | C24H11.1 | Serine/threonine-protein phosphatase. (384 aa) |
| | C24H11.2 | Serine/threonine-protein phosphatase. (384 aa) |
| | C25A6.1 | Serine/threonine-protein phosphatase. (300 aa) |
| | C27B7.6 | Putative serine/threonine-protein phosphatase C27B7.6. (454 aa) |
| | C30A5.4 | Uncharacterized protein C30A5.4. (378 aa) |
| | pph-6 | Serine/threonine-protein phosphatase 6 catalytic subunit; Catalytic subunit of protein phosphatase 6 (PP6) (By similarity). In complex with saps-1, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non- muscle myosin II nmy-2 and thus contributing to correct spindle positioning. Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5. Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily. (331 aa) |
| | C34D4.2 | Serine/threonine-protein phosphatase. (329 aa) |
| | ppm-1.H | PPM-type phosphatase domain-containing protein. (540 aa) |
| | tap-1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. (386 aa) |
| | C47A4.3 | Serine/threonine-protein phosphatase. (316 aa) |
| | vhp-1 | Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa) |
| | F20D6.6 | SER_THR_PHOSPHATASE domain-containing protein. (316 aa) |
| | F22D6.9 | Serine/threonine-protein phosphatase. (368 aa) |
| | F23B12.1 | Serine/threonine-protein phosphatase. (329 aa) |
| | pef-1 | Serine/threonine-protein phosphatase with EF-hands pef-1; Probably acts as a protein phosphatase. (707 aa) |
| | F25B3.4 | Serine/threonine-protein phosphatase. (363 aa) |
| | ppm-1.A | Protein phosphatase ppm-1.A; Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3. Belongs to the PP2C family. (468 aa) |
| | F26B1.5 | Serine/threonine-protein phosphatase. (383 aa) |
| | ilkp-1 | PPM-type phosphatase domain-containing protein. (322 aa) |
| | F40E3.5 | SER_THR_PHOSPHATASE domain-containing protein. (344 aa) |
| | F42G8.8 | Serine/threonine-protein phosphatase. (383 aa) |
| | ppm-1.G | Protein phosphatase ppm-1.G; Belongs to the PP2C family. (491 aa) |
| | phlp-2 | Protein phosphatase PHLPP-like protein; Probable protein phosphatase. (1126 aa) |
| | F44B9.9 | Uncharacterized protein F44B9.9. (244 aa) |
| | cnep-1 | CTD nuclear envelope phosphatase 1 homolog; Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. (276 aa) |
| | F49E11.7 | Serine/threonine-protein phosphatase. (384 aa) |
| | F52H3.6 | Serine/threonine-protein phosphatase. (329 aa) |
| | gsp-2 | Serine/threonine-protein phosphatase PP1-beta; Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA- mediated genome silencing pathway. Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic matu [...] (333 aa) |
| | F58G1.3 | Serine/threonine-protein phosphatase. (364 aa) |
| | ogt-1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase; Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. (1151 aa) |
| | R03D7.8 | SER_THR_PHOSPHATASE domain-containing protein. (596 aa) |
| | pgam-5 | Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity (By similarity). Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (284 aa) |
| | R08A2.2 | Serine/threonine-protein phosphatase. (371 aa) |
| | R08C7.8 | Serine/threonine-protein phosphatase. (362 aa) |
| | rpap-2 | Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2; Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. Belongs to the RPAP2 family. (455 aa) |
| | R13A5.11 | Serine/threonine-protein phosphatase. (459 aa) |
