37 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C04E6.5	USP domain-containing protein. (515 aa)
	cyld-1	USP domain-containing protein. (1144 aa)
	duo-1	Deubiquitylating with USP/UBP and OTU domains; Belongs to the peptidase C19 family. (877 aa)
	F35B3.3	annotation not available (113 aa)
	usp-48	Ubiquitin carboxyl-terminal hydrolase usp-48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression ; Belongs to the peptidase C19 family. (1262 aa)
	atx-3	Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...] (317 aa)
	F23F12.8	Uncharacterized protein F23F12.8. (980 aa)
	otub-3	OTU domain-containing protein. (330 aa)
	usp-39	Ubiquitin Specific Protease. (602 aa)
	F07A11.4	Ubiquitin carboxyl-terminal hydrolase. (1095 aa)
	usp-50	USP domain-containing protein; Belongs to the peptidase C19 family. (811 aa)
	otub-1	Ubiquitin thioesterase otubain-like; Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin. (284 aa)
	usp-14	Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily. (489 aa)
	T22F3.2	USP domain-containing protein. (393 aa)
	T05H10.1	USP domain-containing protein; Belongs to the peptidase C19 family. (1326 aa)
	usp-46	Ubiquitin carboxyl-terminal hydrolase 46; Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity. (426 aa)
	usp-33	Ubiquitin carboxyl-terminal hydrolase. (716 aa)
	K02C4.3	Probable ubiquitin carboxyl-terminal hydrolase K02C4.3. (1261 aa)
	H34C03.2	Ubiquitin carboxyl-terminal hydrolase. (980 aa)
	math-33	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1138 aa)
	H12I13.1	Ubiquitin carboxyl-terminal hydrolase. (910 aa)
	F59E12.6	USP domain-containing protein; Belongs to the peptidase C19 family. (499 aa)
	ubh-1	Ubiquitin carboxyl-terminal hydrolase. (216 aa)
	otub-4	OTU domain-containing protein. (436 aa)
	ubh-4	Ubiquitin carboxyl-terminal hydrolase ubh-4; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin; Belongs to the peptidase C12 family. (321 aa)
	cyk-3	Ubiquitin carboxyl-terminal hydrolase cyk-3; Ubiquitin-protein hydrolase which cleaves ubiquitin from ubiquitinated proteins. Plays a role in embryo osmoregulation. Probably by regulating osmosis, controls actin redistribution in the 1-cell embryos and thus actin-dependent processes such as cytokinesis and P-granules segregation. During the first embryonic mitotic division, involved in the formation of a functional microtubule organizing center provided by the male pronucleus ; Belongs to the peptidase C19 family. (1178 aa)
	josd-1	Josephin domain-containing protein. (173 aa)
	usp-3	Ubiquitin carboxyl-terminal hydrolase. (550 aa)
	Y67D2.2	Ubiquitin carboxyl-terminal hydrolase. (474 aa)
	pqn-87	MATH domain-containing protein. (1485 aa)
	Y55F3AM.9	MINDY_DUB domain-containing protein. (379 aa)
	otub-2	OTU domain-containing protein. (642 aa)
	ubh-2	Ubiquitin carboxyl-terminal hydrolase. (227 aa)
	ubh-3	Ubiquitin carboxyl-terminal hydrolase. (227 aa)
	duo-3	Deubiquitylating with USP/UBP and OTU domains. (924 aa)
	usp-5	Ubiquitin carboxyl-terminal hydrolase. (789 aa)
	T24B8.7	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (2938 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F07A11.4	K02C4.3	F07A11.4a.1	K02C4.3a.1	Ubiquitin carboxyl-terminal hydrolase.	Probable ubiquitin carboxyl-terminal hydrolase K02C4.3.	0.404
F07A11.4	Y67D2.2	F07A11.4a.1	Y67D2.2.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.423
F07A11.4	cyld-1	F07A11.4a.1	F40F12.5a.1	Ubiquitin carboxyl-terminal hydrolase.	USP domain-containing protein.	0.745
F07A11.4	math-33	F07A11.4a.1	H19N07.2k.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins.	0.482
F07A11.4	otub-3	F07A11.4a.1	F21D5.2b.1	Ubiquitin carboxyl-terminal hydrolase.	OTU domain-containing protein.	0.770
F07A11.4	ubh-4	F07A11.4a.1	C08B11.7.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase ubh-4; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin; Belongs to the peptidase C12 family.	0.548
F07A11.4	usp-14	F07A11.4a.1	C13B4.2.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily.	0.470
F07A11.4	usp-48	F07A11.4a.1	F30A10.10.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase usp-48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression ; Belongs to the peptidase C19 family.	0.431
F07A11.4	usp-5	F07A11.4a.1	T27A3.2.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.478
F07A11.4	usp-50	F07A11.4a.1	E01B7.1.2	Ubiquitin carboxyl-terminal hydrolase.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.429
H34C03.2	K02C4.3	H34C03.2b.1	K02C4.3a.1	Ubiquitin carboxyl-terminal hydrolase.	Probable ubiquitin carboxyl-terminal hydrolase K02C4.3.	0.452
H34C03.2	Y67D2.2	H34C03.2b.1	Y67D2.2.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.439
H34C03.2	cyld-1	H34C03.2b.1	F40F12.5a.1	Ubiquitin carboxyl-terminal hydrolase.	USP domain-containing protein.	0.734
H34C03.2	math-33	H34C03.2b.1	H19N07.2k.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins.	0.593
H34C03.2	otub-3	H34C03.2b.1	F21D5.2b.1	Ubiquitin carboxyl-terminal hydrolase.	OTU domain-containing protein.	0.774
H34C03.2	usp-14	H34C03.2b.1	C13B4.2.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily.	0.500
H34C03.2	usp-48	H34C03.2b.1	F30A10.10.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase usp-48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression ; Belongs to the peptidase C19 family.	0.404
H34C03.2	usp-5	H34C03.2b.1	T27A3.2.1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.639
H34C03.2	usp-50	H34C03.2b.1	E01B7.1.2	Ubiquitin carboxyl-terminal hydrolase.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.446
K02C4.3	F07A11.4	K02C4.3a.1	F07A11.4a.1	Probable ubiquitin carboxyl-terminal hydrolase K02C4.3.	Ubiquitin carboxyl-terminal hydrolase.	0.404