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| | tag-52 | Putative protein tag-52. (665 aa) |
| | ced-5 | CED-5. (1781 aa) |
| | aex-3 | MAP kinase-activating death domain protein; Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. Probably by converting rab-3 to its GTP-bound active form, plays a role [...] (1409 aa) |
| | rei-1 | Guanine nucleotide exchange factor rei-1; Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows. (244 aa) |
| | unc-89 | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa) |
| | mcp-1 | GDP-D-glucose phosphorylase 1; Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. Belongs to the GDPGP1 family. (482 aa) |
| | tiam-1 | DH domain-containing protein. (889 aa) |
| | cgef-1 | DH domain-containing protein. (1055 aa) |
| | eif-2Bgamma | Probable translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family. (404 aa) |
| | gbf-1 | SEC7 domain-containing protein. (1975 aa) |
| | ran-3 | Regulator of chromosome condensation; Key component of the Ran GTPase system, which comprises ran- 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. (569 aa) |
| | tag-77 | Uncharacterized protein. (1006 aa) |
| | exc-5 | Uncharacterized protein. (861 aa) |
| | vav-1 | Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa) |
| | rin-1 | VPS9 domain-containing protein. (1890 aa) |
| | lst-6 | Lateral Signaling Target. (1487 aa) |
| | eif-2Bepsilon | W2 domain-containing protein. (666 aa) |
| | glo-4 | X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. (1386 aa) |
| | rhgf-1 | RHo Guanine nucleotide exchange Factor. (1340 aa) |
| | alfa-1 | ALS/FTD Associated gene homolog. (734 aa) |
| | flcn-1 | UDENN FLCN/SMCR8-type domain-containing protein. (707 aa) |
| | F22G12.5 | DHR-2 domain-containing protein; Belongs to the DOCK family. (2338 aa) |
| | rgef-1 | Rap Guanine nucleotide Exchange Factor homolog. (654 aa) |
| | rgl-1 | Ral GDS-Like. (880 aa) |
| | plc-1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity (By similarity). By activating IP3 receptor itr-1-mediated intracellular Ca(2+) release via the production of IP3, regulates ovulation by controlling contraction and/or dilation of the di [...] (1898 aa) |
| | uig-1 | PH domain-containing protein. (972 aa) |
| | rme-4 | UDENN domain-containing protein. (661 aa) |
| | F46H5.4 | Uncharacterized protein; Belongs to the DOCK family. (2018 aa) |
| | rme-6 | Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits. (1093 aa) |
| | F53H1.3 | UDENN domain-containing protein. (554 aa) |
| | F54C9.11 | Uncharacterized protein. (367 aa) |
| | eef-1B.1 | Probable elongation factor 1-beta/1-delta 1; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP; Belongs to the EF-1-beta/EF-1-delta family. (213 aa) |
| | unc-73 | Guanine nucleotide exchange factor UNC-73A. (2488 aa) |
| | sam-4 | Uncharacterized protein. (240 aa) |
| | gbas-1 | G-protein alpha subunit activating protein gbas-1; Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates G-protein alpha subunit goa-1. (758 aa) |
| | frm-3 | FERM domain-containing protein. (1091 aa) |
| | sec-12 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | grp-1 | GTP exchange factor for ARFs 1; Promotes guanine-nucleotide exchange on ARF. Promotes the activation of ARF through replacement of GDP with GTP (By similarity). Plays a role in cell shedding during embryogenesis, probably by promoting the endocytosis of cell adhesion molecules. (393 aa) |
| | ephx-1 | EPHeXin (Eph-interacting GEF) homolog. (1159 aa) |
| | pix-1 | PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa) |
| | bris-1 | SEC7 domain-containing protein. (640 aa) |
| | osg-1 | Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa) |
| | R05G6.10 | Ras-GEF domain-containing protein. (547 aa) |
| | R06F6.8 | Guanine nucleotide exchange factor subunit R06F6.8; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi; Belongs to the RIC1 family. (1470 aa) |
| | smcr-8 | Guanine nucleotide exchange protein smcr-8; Part of a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy; Belongs to the SMCR8 family. (511 aa) |
| | sma-1 | SMAll. (4166 aa) |
| | rhgf-2 | DH domain-containing protein. (1149 aa) |
| | pxf-1 | Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family. (1470 aa) |
| | ect-2 | ECT2 (Mammalian Rho GEF) homolog. (932 aa) |
| | epac-1 | Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1. (1038 aa) |
| | sos-1 | Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa) |
| | W09G3.7 | Uncharacterized protein. (404 aa) |
| | Y105E8A.25 | DH domain-containing protein. (1619 aa) |
| | Y106G6G.2 | SEC7 domain-containing protein. (1655 aa) |
| | Y34B4A.4 | Uncharacterized protein. (877 aa) |
| | Y37A1B.17 | Uncharacterized protein. (1523 aa) |
| | rabx-5 | RAB eXchange factor. (517 aa) |
| | eef-1B.2 | Probable elongation factor 1-beta/1-delta 2; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. (440 aa) |
| | efa-6 | Exchange factor for Arf-6; Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells. (818 aa) |
| | mdt-9 | Putative guanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily. (147 aa) |
| | ric-8 | Synembryn; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein couple [...] (566 aa) |
| | agef-1 | SEC7 domain-containing protein. (1594 aa) |
| | Y95B8A.12 | Pleckstrin homology and RHoGef (RhoGEF) domain containing. (628 aa) |
| | lmtr-2 | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. (124 aa) |
| | ZK970.8 | Uncharacterized protein. (143 aa) |
