STRINGSTRING
ifd-2 ifd-2 tba-1 tba-1 tba-6 tba-6 F35A5.1 F35A5.1 ifc-1 ifc-1 ifa-1 ifa-1 tba-9 tba-9 tba-4 tba-4 ifa-3 ifa-3 tbg-1 tbg-1 tbb-1 tbb-1 ifa-4 ifa-4 unc-70 unc-70 act-4 act-4 ifc-2 ifc-2 ifd-1 ifd-1 act-1 act-1 tbb-6 tbb-6 tba-7 tba-7 mua-6 mua-6 Y19D2B.1 Y19D2B.1 arx-4 arx-4 tln-1 tln-1 deb-1 deb-1 mec-7 mec-7 tba-8 tba-8 tbb-4 tbb-4 tbb-2 tbb-2 ifp-1 ifp-1 mec-12 mec-12 tba-2 tba-2 ben-1 ben-1 lmn-1 lmn-1 ifb-1 ifb-1 ifb-2 ifb-2 F10C1.8 F10C1.8 tba-5 tba-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ifd-2Intermediate filament protein ifd-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (443 aa)
tba-1Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
tba-6Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (464 aa)
F35A5.1Uncharacterized protein. (2311 aa)
ifc-1Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (500 aa)
ifa-1Intermediate filament protein ifa-1; Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis. (592 aa)
tba-9Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
tba-4Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
ifa-3Intermediate filament protein ifa-3; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures. (581 aa)
tbg-1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (444 aa)
tbb-1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ifa-4Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein. (575 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2326 aa)
act-4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
ifc-2Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion. (1248 aa)
ifd-1Intermediate filament protein ifd-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (575 aa)
act-1Actin-1. (376 aa)
tbb-6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (426 aa)
tba-7Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
mua-6Intermediate filament protein ifa-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle- cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos. (581 aa)
Y19D2B.1Uncharacterized protein. (85 aa)
arx-4Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa)
tln-1Talin. (2553 aa)
deb-1Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa)
mec-7Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity). (441 aa)
tba-8Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
tbb-4Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
tbb-2Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (450 aa)
ifp-1Intermediate filament protein ifp-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (776 aa)
mec-12Detyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Component of the large-diameter neuronal microtubules which contains 15 protofilaments. Plays a role in mechanosensory transduction (touch sensitivity). (450 aa)
tba-2Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (448 aa)
ben-1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
lmn-1Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa)
ifb-1Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. (589 aa)
ifb-2Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. (577 aa)
F10C1.8LTD domain-containing protein. (160 aa)
tba-5Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (447 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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