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twk-8 twk-8 shk-1 shk-1 twk-9 twk-9 twk-4 twk-4 tax-4 tax-4 lron-12 lron-12 shl-1 shl-1 twk-44 twk-44 twk-45 twk-45 kvs-5 kvs-5 kqt-3 kqt-3 slo-1 slo-1 kvs-4 kvs-4 twk-31 twk-31 twk-46 twk-46 egl-23 egl-23 twk-33 twk-33 twk-42 twk-42 twk-40 twk-40 twk-2 twk-2 unc-58 unc-58 twk-22 twk-22 twk-21 twk-21 shw-3 shw-3 twk-36 twk-36 egl-36 egl-36 twk-49 twk-49 twk-13 twk-13 irk-1 irk-1 kqt-2 kqt-2 twk-3 twk-3 twk-25 twk-25 irk-2 irk-2 twk-48 twk-48 twk-34 twk-34 irk-3 irk-3 twk-10 twk-10 twk-14 twk-14 twk-24 twk-24 twk-32 twk-32 twk-16 twk-16 twk-29 twk-29 kvs-3 kvs-3 twk-30 twk-30 sup-9 sup-9 twk-47 twk-47 twk-43 twk-43 twk-35 twk-35 twk-12 twk-12 twk-7 twk-7 twk-1 twk-1 twk-11 twk-11 twk-23 twk-23 twk-6 twk-6 egl-2 egl-2 shw-1 shw-1 exp-2 exp-2 slo-2 slo-2 kvs-1 kvs-1 twk-28 twk-28 twk-37 twk-37 twk-17 twk-17 twk-20 twk-20 twk-26 twk-26 C32C4.1 C32C4.1 unc-103 unc-103 C27F2.6 C27F2.6 kqt-1 kqt-1 twk-39 twk-39 twk-18 twk-18 B0310.1 B0310.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
twk-8TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (769 aa)
shk-1Potassium voltage-gated channel protein shk-1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d. (536 aa)
twk-9TWiK family of potassium channels protein 9; Potassium channel protein that may be component of regulatory network that controls ray development and function. (568 aa)
twk-4TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (418 aa)
tax-4Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] (733 aa)
lron-12ELRR (Extracellular Leucine-Rich Repeat) ONly. (401 aa)
shl-1BTB domain-containing protein; Belongs to the potassium channel family. (578 aa)
twk-44TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (733 aa)
twk-45TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (508 aa)
kvs-5Ion_trans domain-containing protein; Belongs to the potassium channel family. (600 aa)
kqt-3Potassium channel, KvQLT family; Belongs to the potassium channel family. (621 aa)
slo-1Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa)
kvs-4Probable voltage-gated potassium channel subunit kvs-4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. (512 aa)
twk-31TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (1136 aa)
twk-46Two pore potassium channel protein sup-9. (319 aa)
egl-23Uncharacterized protein; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (726 aa)
twk-33TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (617 aa)
twk-42TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (444 aa)
twk-40TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (436 aa)
twk-2TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (1519 aa)
unc-58Uncoordinated protein 58; Has a role in mobility, possibly in the transport of potassium in muscles; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (591 aa)
twk-22TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (757 aa)
twk-21TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (581 aa)
shw-3BTB domain-containing protein; Belongs to the potassium channel family. (500 aa)
twk-36TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (562 aa)
egl-36Potassium voltage-gated channel protein egl-36; Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily. (558 aa)
twk-49Ion_trans_2 domain-containing protein. (337 aa)
twk-13TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (625 aa)
irk-1Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. (544 aa)
kqt-2Ion_trans domain-containing protein; Belongs to the potassium channel family. (695 aa)
twk-3TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (383 aa)
twk-25TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (683 aa)
irk-2Inward Rectifying K (Potassium) channel family. (497 aa)
twk-48TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (372 aa)
twk-34TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (558 aa)
irk-3IRK_C domain-containing protein. (384 aa)
twk-10TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (429 aa)
twk-14TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (463 aa)
twk-24TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (579 aa)
twk-32TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (614 aa)
twk-16TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (555 aa)
twk-29TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (476 aa)
kvs-3Uncharacterized protein; Belongs to the potassium channel family. (451 aa)
twk-30TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (608 aa)
sup-9Two pore potassium channel protein sup-9; Potassium channel involved in coordination of muscle contraction. Activity is regulated by sup-18 ; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (329 aa)
twk-47Ion_trans_2 domain-containing protein. (500 aa)
twk-43TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (597 aa)
twk-35TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (557 aa)
twk-12TWiK family of potassium channels protein 12. (684 aa)
twk-7TWiK family of potassium channels protein 7. (557 aa)
twk-1TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (451 aa)
twk-11TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (1720 aa)
twk-23TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (443 aa)
twk-6TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (347 aa)
egl-2Uncharacterized protein. (959 aa)
shw-1BTB domain-containing protein; Belongs to the potassium channel family. (619 aa)
exp-2Uncharacterized protein; Belongs to the potassium channel family. (510 aa)
slo-2Ion_trans_2 domain-containing protein. (1143 aa)
kvs-1Uncharacterized protein; Belongs to the potassium channel family. (495 aa)
twk-28TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (523 aa)
twk-37TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (382 aa)
twk-17Putative potassium channel subunit n2P17m2-2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (576 aa)
twk-20Two pore potassium channel protein sup-9. (364 aa)
twk-26TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (519 aa)
C32C4.1BTB domain-containing protein; Belongs to the potassium channel family. (575 aa)
unc-103Potassium voltage-gated channel unc-103; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior ; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (898 aa)
C27F2.6Uncharacterized protein. (165 aa)
kqt-1Potassium channel, KvQLT family; Belongs to the potassium channel family. (740 aa)
twk-39TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (676 aa)
twk-18TWiK family of potassium channels protein 18; Outwardly rectifying potassium channel protein; activity is sharply augmented by increase in temperature. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (461 aa)
B0310.1Uncharacterized protein B0310.1. (292 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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