node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dyb-1 | snf-6 | F47G6.1a.1 | M01G5.5.1 | Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. | Sodium-dependent acetylcholine transporter; Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-gly [...] | 0.700 |
dyb-1 | stn-1 | F47G6.1a.1 | F30A10.8.1 | Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. | Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance. | 0.996 |
eat-4 | unc-17 | ZK512.6a.1 | ZC416.8a.1 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.851 |
eat-4 | vglu-2 | ZK512.6a.1 | K10G9.1.1 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. | MFS domain-containing protein. | 0.480 |
eat-4 | vglu-3 | ZK512.6a.1 | T07A5.3.1 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. | Potential vesicular glutamate transporter vglu-3. | 0.448 |
snf-6 | dyb-1 | M01G5.5.1 | F47G6.1a.1 | Sodium-dependent acetylcholine transporter; Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-gly [...] | Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. | 0.700 |
snf-6 | stn-1 | M01G5.5.1 | F30A10.8.1 | Sodium-dependent acetylcholine transporter; Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-gly [...] | Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance. | 0.605 |
stn-1 | dyb-1 | F30A10.8.1 | F47G6.1a.1 | Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance. | Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. | 0.996 |
stn-1 | snf-6 | F30A10.8.1 | M01G5.5.1 | Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance. | Sodium-dependent acetylcholine transporter; Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-gly [...] | 0.605 |
unc-17 | eat-4 | ZC416.8a.1 | ZK512.6a.1 | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. | 0.851 |
unc-17 | vglu-2 | ZC416.8a.1 | K10G9.1.1 | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. | MFS domain-containing protein. | 0.661 |
vglu-2 | eat-4 | K10G9.1.1 | ZK512.6a.1 | MFS domain-containing protein. | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. | 0.480 |
vglu-2 | unc-17 | K10G9.1.1 | ZC416.8a.1 | MFS domain-containing protein. | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. | 0.661 |
vglu-2 | vglu-3 | K10G9.1.1 | T07A5.3.1 | MFS domain-containing protein. | Potential vesicular glutamate transporter vglu-3. | 0.432 |
vglu-3 | eat-4 | T07A5.3.1 | ZK512.6a.1 | Potential vesicular glutamate transporter vglu-3. | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. | 0.448 |
vglu-3 | vglu-2 | T07A5.3.1 | K10G9.1.1 | Potential vesicular glutamate transporter vglu-3. | MFS domain-containing protein. | 0.432 |