STRINGSTRING
Y69A2AR.21 Y69A2AR.21 uaf-1 uaf-1 ZK1098.1 ZK1098.1 ZK1307.9 ZK1307.9 eftu-2 eftu-2 lsm-7 lsm-7 B0495.8 B0495.8 stip-1 stip-1 C50D2.5 C50D2.5 C50D2.8 C50D2.8 syf-1 syf-1 smu-1 smu-1 F08B4.7 F08B4.7 repo-1 repo-1 F25B4.5 F25B4.5 lsm-4 lsm-4 F32B6.3 F32B6.3 F37C12.1 F37C12.1 F40F8.11 F40F8.11 mfap-1 mfap-1 F43G9.12 F43G9.12 mog-3 mog-3 rnf-113 rnf-113 rnp-7 rnp-7 M03F8.3 M03F8.3 R08D7.1 R08D7.1 sftb-1 sftb-1 prp-19 prp-19 rbm-22 rbm-22 snr-3 snr-3 sftb-2 sftb-2 prp-21 prp-21 snr-2 snr-2 snr-1 snr-1 Y119D3B.12 Y119D3B.12 cus-2 cus-2 snr-7 snr-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y69A2AR.21Uncharacterized protein. (169 aa)
uaf-1Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (496 aa)
ZK1098.1WW domain-containing protein ZK1098.1. (724 aa)
ZK1307.9Coiled-coil domain-containing protein 130 homolog. (369 aa)
eftu-2Tr-type G domain-containing protein. (974 aa)
lsm-7Sm domain-containing protein. (104 aa)
B0495.8Uncharacterized protein B0495.8; Belongs to the Luc7 family. (313 aa)
stip-1Septin and tuftelin-interacting protein 1 homolog; May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival. (830 aa)
C50D2.5Splicing factor 3B subunit 6-like protein; Necessary for the splicing of pre-mRNA. (138 aa)
C50D2.8Uncharacterized protein. (319 aa)
syf-1SYF pre-mRNA splicing factor homolog. (855 aa)
smu-1Smu-1 suppressor of mec-8 and unc-52 protein; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site. In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18. (510 aa)
F08B4.7U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (142 aa)
repo-1Matrin-type domain-containing protein. (222 aa)
F25B4.5Uncharacterized protein. (710 aa)
lsm-4Probable U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (123 aa)
F32B6.3SFM domain-containing protein. (352 aa)
F37C12.1Uncharacterized protein. (323 aa)
F40F8.11DUF1768 domain-containing protein. (472 aa)
mfap-1Microfibrillar-associated protein 1; Involved in pre-mRNA splicing. (466 aa)
F43G9.12GCFC domain-containing protein. (809 aa)
mog-3Sex determining protein MOG-3. (451 aa)
rnf-113Probable E3 ubiquitin-protein ligase rnf113; May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents. (384 aa)
rnp-7RRM domain-containing protein. (332 aa)
M03F8.3Uncharacterized protein. (747 aa)
R08D7.1BUD13 homolog; Belongs to the CWC26 family. (458 aa)
sftb-1SF3b1 domain-containing protein. (1322 aa)
prp-19Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa)
rbm-22RNA Binding Motif protein homolog. (408 aa)
snr-3Probable small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures (By similarity). Belongs to the snRNP core protein family. (126 aa)
sftb-2PSP domain-containing protein. (602 aa)
prp-21Yeast PRP (Splicing factor) related. (655 aa)
snr-2Probable small nuclear ribonucleoprotein-associated protein B; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure (By similarity); Belongs to the snRNP SmB/SmN family. (160 aa)
snr-1Small nuclear ribonucleoprotein Sm D3; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity); Belongs to the snRNP core protein family. (136 aa)
Y119D3B.12Uncharacterized protein. (339 aa)
cus-2Uncharacterized protein. (442 aa)
snr-7Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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