STRINGSTRING
dct-1 dct-1 tomm-40 tomm-40 lgg-1 lgg-1 gop-3 gop-3 C41G7.9 C41G7.9 wdr-23 wdr-23 F11C1.7 F11C1.7 fis-2 fis-2 tomm-20 tomm-20 F32B4.2 F32B4.2 mtx-1 mtx-1 fis-1 fis-1 F49E10.4 F49E10.4 mff-2 mff-2 spd-3 spd-3 moma-1 moma-1 mspn-1 mspn-1 K05C4.7 K05C4.7 pdr-1 pdr-1 miro-1 miro-1 M110.3 M110.3 vdac-1 vdac-1 kmo-2 kmo-2 kmo-1 kmo-1 pgam-5 pgam-5 pde-2 pde-2 fndc-1 fndc-1 ced-9 ced-9 cisd-1 cisd-1 tomm-22 tomm-22 slc-25A46 slc-25A46 cpt-1 cpt-1 mtx-2 mtx-2 fzo-1 fzo-1 tomm-70 tomm-70 tomm-7 tomm-7 acl-3 acl-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dct-1NIP3 homolog; Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth. Required for the induction of mitophagy under stress conditions. Belongs to the NIP3 family. (221 aa)
tomm-40Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development. (301 aa)
lgg-1Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] (123 aa)
gop-3SAM50-like protein gop-3; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family. (434 aa)
C41G7.9Uncharacterized protein. (212 aa)
wdr-23DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa)
F11C1.7Uncharacterized protein. (137 aa)
fis-2Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa)
tomm-20Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with tomm-22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. (188 aa)
F32B4.2Uncharacterized protein. (167 aa)
mtx-1Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family. (312 aa)
fis-1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (143 aa)
F49E10.4MIEAP domain-containing protein. (645 aa)
mff-2Mitochondrial Fission Factor. (161 aa)
spd-3Uncharacterized protein. (478 aa)
moma-1MICOS complex subunit MIC27; Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity). (201 aa)
mspn-1Mitochondrial sorting homolog; Involved in intramitochondrial sorting of proteins. (342 aa)
K05C4.7Armadillo repeat-containing protein 1. (289 aa)
pdr-1E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa)
miro-1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (625 aa)
M110.3RING-CH-type domain-containing protein. (189 aa)
vdac-1Probable voltage-dependent anion-selective channel; Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. (283 aa)
kmo-2FAD_binding_3 domain-containing protein. (445 aa)
kmo-1Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (461 aa)
pgam-5Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity (By similarity). Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (284 aa)
pde-2Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. (831 aa)
fndc-1FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage. (138 aa)
ced-9Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa)
cisd-1ZnF_CDGSH domain-containing protein. (134 aa)
tomm-22Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor tomm-20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. (109 aa)
slc-25A46SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (500 aa)
cpt-1Carnitine Palmitoyl Transferase; Belongs to the carnitine/choline acetyltransferase family. (779 aa)
mtx-2Metaxin-2 homolog. (260 aa)
fzo-1Transmembrane GTPase fzo-1; Probable transmembrane GTPase (By similarity). Mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (774 aa)
tomm-70Mitochondrial import receptor subunit tomm-70; Receptor that accelerates the import of all mitochondrial precursor proteins; Belongs to the Tom70 family. (554 aa)
tomm-7Mitochondrial import receptor subunit TOM7 homolog; Belongs to the Tom7 family. (58 aa)
acl-3Tafazzin family protein; Belongs to the taffazin family. (284 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (18%) [HD]