STRINGSTRING
Y105E8B.9 Y105E8B.9 Y113G7B.15 Y113G7B.15 Y22D7AL.15 Y22D7AL.15 ragc-1 ragc-1 Y37D8A.2 Y37D8A.2 Y37D8A.26 Y37D8A.26 Y37D8A.6 Y37D8A.6 Y37D8A.8 Y37D8A.8 asp-1 asp-1 asp-15 asp-15 asp-16 asp-16 asp-17 asp-17 Y40H7A.10 Y40H7A.10 Y40H7A.11 Y40H7A.11 Y41C4A.11 Y41C4A.11 npp-18 npp-18 laat-1 laat-1 Y51A2D.1 Y51A2D.1 Y51A2D.8 Y51A2D.8 Y55D5A.3 Y55D5A.3 marc-5 marc-5 arl-8 arl-8 Y65B4A.2 Y65B4A.2 Y71H2AM.2 Y71H2AM.2 Y71H2AM.25 Y71H2AM.25 Y71H2AR.2 Y71H2AR.2 npp-20 npp-20 Y87G2A.18 Y87G2A.18 Y87G2A.19 Y87G2A.19 cln-3.3 cln-3.3 asp-18 asp-18 asp-19 asp-19 asm-2 asm-2 haf-9 haf-9 spe-4 spe-4 lipl-5 lipl-5 chup-1 chup-1 mel-26 mel-26 cdr-4 cdr-4 asp-3 asp-3 sam-4 sam-4 F57F5.1 F57F5.1 F55H2.5 F55H2.5 aman-1 aman-1 lipl-1 lipl-1 unc-108 unc-108 F52E1.9 F52E1.9 cima-1 cima-1 ppt-1 ppt-1 cpr-4 cpr-4 tag-196 tag-196 aagr-3 aagr-3 F39F10.5 F39F10.5 hrg-5 hrg-5 hrg-4 hrg-4 hrg-6 hrg-6 F36G3.3 F36G3.3 cpr-2 cpr-2 sel-12 sel-12 nprl-3 nprl-3 cdr-1 cdr-1 F32H5.1 F32H5.1 cpz-1 cpz-1 vps-41 vps-41 asp-13 asp-13 asah-2 asah-2 exl-1 exl-1 F26E4.3 F26E4.3 flcn-1 flcn-1 asp-6 asp-6 asp-12 asp-12 asp-5 asp-5 F21F3.6 F21F3.6 F16F9.1 F16F9.1 F15D4.4 F15D4.4 F13H10.3 F13H10.3 F11G11.5 F11G11.5 cln-3.1 cln-3.1 ncr-1 ncr-1 aagr-1 aagr-1 vps-33.2 vps-33.2 lmp-1 lmp-1 cln-3.2 cln-3.2 B0348.2 B0348.2 B0348.1 B0348.1 marc-4 marc-4 vps-33.1 vps-33.1 asm-1 asm-1 cpr-1 cpr-1 tag-329 tag-329 ilys-3 ilys-3 ctns-1 ctns-1 C39D10.6 C39D10.6 imp-1 imp-1 gop-1 gop-1 cup-16 cup-16 C33G3.4 C33G3.4 lgg-1 lgg-1 C32B5.7 C32B5.7 C32B5.13 C32B5.13 C30F12.3 C30F12.3 C30E1.4 C30E1.4 C29E4.10 C29E4.10 spp-10 spp-10 cpr-6 cpr-6 hop-1 hop-1 hrg-7 hrg-7 ril-2 ril-2 asp-9 asp-9 C08E8.1 C08E8.1 C08A9.3 C08A9.3 nuc-1 nuc-1 C05E11.3 C05E11.3 lmp-2 lmp-2 vps-16 vps-16 sid-1 sid-1 K02E7.10 K02E7.10 lipl-4 lipl-4 K10C9.3 K10C9.3 blos-9 blos-9 asah-1 asah-1 cpz-2 cpz-2 hrg-1 hrg-1 blos-8 blos-8 R04B3.2 R04B3.2 aagr-2 aagr-2 vps-11 vps-11 clh-6 clh-6 R07E3.1 R07E3.1 R09F10.1 R09F10.1 lipl-3 lipl-3 R12C12.6 R12C12.6 asp-4 asp-4 cup-5 cup-5 lmtr-5 lmtr-5 cpl-1 cpl-1 T08A11.1 T08A11.1 vps-39 vps-39 T10B10.3 T10B10.3 cpr-3 cpr-3 hex-1 hex-1 asp-2 asp-2 lbp-8 lbp-8 raga-1 raga-1 T28C6.8 T28C6.8 rab-7 rab-7 asm-3 asm-3 W03G11.3 W03G11.3 haf-4 haf-4 dct-11 dct-11 vps-18 vps-18 cpr-8 cpr-8 W07B8.4 W07B8.4 cpr-5 cpr-5 catp-6 catp-6 exc-4 exc-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y105E8B.9Uncharacterized protein. (628 aa)
Y113G7B.15Uncharacterized protein; Belongs to the peptidase C1 family. (362 aa)
Y22D7AL.15LITAF domain-containing protein. (152 aa)
ragc-1RAs-related GTP binding protein C homolog. (338 aa)
Y37D8A.2Putative phospholipase B-like 1; Putative phospholipase; Belongs to the phospholipase B-like family. (571 aa)
Y37D8A.26LITAF domain-containing protein. (88 aa)
Y37D8A.6LITAF domain-containing protein. (132 aa)
Y37D8A.8LITAF domain-containing protein. (130 aa)
asp-1Aspartic protease 1; Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis ; Belongs to the peptidase A1 family. (396 aa)
asp-15Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
asp-16Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
asp-17Aspartic protease 17; Aspartic proteinase; Belongs to the peptidase A1 family. (391 aa)
Y40H7A.10Uncharacterized protein; Belongs to the peptidase C1 family. (343 aa)
Y40H7A.11LITAF domain-containing protein. (124 aa)
Y41C4A.11LITAF domain-containing protein. (101 aa)
npp-18Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus. (363 aa)
laat-1Lysosomal amino acid transporter 1; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function ; Belongs to the laat-1 family. (311 aa)
Y51A2D.1Uncharacterized protein; Belongs to the peptidase C1 family. (314 aa)
Y51A2D.8Uncharacterized protein; Belongs to the peptidase C1 family. (386 aa)
Y55D5A.3N-acylethanolamine-hydrolyzing acid amidase subunit alpha; Degrades bioactive fatty acid amides, such as N- palmitoylethanolamine, to ethanolamine and free fatty acids. Belongs to the acid ceramidase family. (355 aa)
marc-5RING-CH-type domain-containing protein. (470 aa)
arl-8Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. (185 aa)
Y65B4A.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (448 aa)
Y71H2AM.2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (251 aa)
Y71H2AM.25Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa)
Y71H2AR.2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (345 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa)
Y87G2A.18LITAF domain-containing protein. (118 aa)
Y87G2A.19LITAF domain-containing protein. (110 aa)
cln-3.3Battenin. (417 aa)
asp-18Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (392 aa)
asp-19Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (223 aa)
asm-2Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (618 aa)
haf-9ABC transmembrane type-1 domain-containing protein. (815 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
lipl-5Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (403 aa)
chup-1CHolesterol UPtake associated. (756 aa)
mel-26Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway. (399 aa)
cdr-4Cadmium-inducible lysosomal protein CDR-4. (277 aa)
asp-3Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa)
sam-4Uncharacterized protein. (240 aa)
F57F5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
F55H2.5Putative cytochrome b561. (266 aa)
aman-1Alpha-mannosidase. (955 aa)
lipl-1Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (405 aa)
unc-108Uncharacterized protein. (223 aa)
F52E1.9Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (181 aa)
cima-1MFS domain-containing protein. (543 aa)
ppt-1Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. (298 aa)
cpr-4Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
tag-196Uncharacterized protein; Belongs to the peptidase C1 family. (477 aa)
aagr-3DUF5110 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (924 aa)
F39F10.5Uncharacterized protein. (177 aa)
hrg-5Heme transporter hrg-5; Heme transporter. (160 aa)
hrg-4Heme transporter hrg-4; Heme transporter that mediates heme uptake across the plasma membrane; Belongs to the HRG family. (184 aa)
hrg-6Heme transporter hrg-6; Heme transporter. (161 aa)
F36G3.3LITAF domain-containing protein. (148 aa)
cpr-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
nprl-3GATOR complex protein NPRL3; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (511 aa)
cdr-1Cadmium-inducible lysosomal protein CDR-1. (277 aa)
F32H5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
cpz-1Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa)
vps-41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa)
asp-13Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (389 aa)
asah-2Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (401 aa)
exl-1Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family. (238 aa)
F26E4.3Uncharacterized peptidase C1-like protein F26E4.3. (452 aa)
flcn-1UDENN FLCN/SMCR8-type domain-containing protein. (707 aa)
asp-6Aspartic protease 6; Aspartic protease; Belongs to the peptidase A1 family. (389 aa)
asp-12Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (395 aa)
asp-5Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (393 aa)
F21F3.6Uncharacterized protein. (234 aa)
F16F9.1LITAF domain-containing protein. (157 aa)
F15D4.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (608 aa)
F13H10.3Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. (617 aa)
F11G11.5Uncharacterized protein. (223 aa)
cln-3.1Battenin. (424 aa)
ncr-1NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family. (1383 aa)
aagr-1P-type domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (936 aa)
vps-33.2Vacuolar protein sorting-associated protein 33B; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a rab-5 effector to mediate early endoso [...] (617 aa)
lmp-1LAMP family protein lmp-1; Belongs to the LAMP family. (237 aa)
cln-3.2Battenin. (435 aa)
B0348.2LITAF domain-containing protein. (86 aa)
B0348.1LITAF domain-containing protein. (87 aa)
marc-4RING-CH-type domain-containing protein. (317 aa)
vps-33.1Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE- mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate lat [...] (603 aa)
asm-1Sphingomyelin phosphodiesterase 1; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (564 aa)
cpr-1Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
tag-329Uncharacterized protein; Belongs to the peptidase C1 family. (374 aa)
ilys-3Invertebrate-type lysozyme 3; Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria; Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily. (139 aa)
ctns-1Cystinosin homolog; Thought to transport cystine out of lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells. (404 aa)
C39D10.6Uncharacterized protein. (228 aa)
imp-1IntraMembrane Protease (IMPAS) family. (662 aa)
gop-1Protein CLEC16A homolog; Regulator of mitophagy. (892 aa)
cup-16Uncharacterized protein. (392 aa)
C33G3.4Probable beta-mannosidase; Belongs to the glycosyl hydrolase 2 family. (900 aa)
lgg-1Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] (123 aa)
C32B5.7Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (234 aa)
C32B5.13Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (150 aa)
C30F12.3Uncharacterized protein. (264 aa)
C30E1.4Uncharacterized protein. (290 aa)
C29E4.10Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family. (645 aa)
spp-10SaPosin-like Protein family. (429 aa)
cpr-6Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
hrg-7Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (428 aa)
ril-2RNAi-Induced Longevity. (677 aa)
asp-9Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (390 aa)
C08E8.1LITAF domain-containing protein. (102 aa)
C08A9.3Uncharacterized protein. (739 aa)
nuc-1Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family. (375 aa)
C05E11.3Uncharacterized protein. (257 aa)
lmp-2LAMP (Lysosome-associated membrane protein) homolog. (296 aa)
vps-16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the la [...] (852 aa)
sid-1Systemic RNA interference defective protein 1; Plays a role in RNA-mediated gene silencing by acting cell- autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Belongs to the SID1 family. (776 aa)
K02E7.10Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (299 aa)
lipl-4Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (411 aa)
K10C9.3Ribonuclease T2 protein rnst-2; Probable endoribonuclease involved in the autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes. (279 aa)
blos-9BLOC-1-related complex subunit 8 homolog; May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor; Belongs to the BORCS8 family. (151 aa)
asah-1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. (393 aa)
cpz-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (467 aa)
hrg-1Heme transporter hrg-1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. Belongs to the HRG family. (194 aa)
blos-8BLOC (Biogenesis of Lysosome-related Organelles Complex) and Related complexes subunit homolog. (126 aa)
R04B3.2Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. (363 aa)
aagr-2P-type domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (955 aa)
vps-11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] (980 aa)
clh-6Chloride channel protein. (796 aa)
R07E3.1Uncharacterized protein; Belongs to the peptidase C1 family. (402 aa)
R09F10.1Uncharacterized protein; Belongs to the peptidase C1 family. (383 aa)
lipl-3Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (404 aa)
R12C12.6Uncharacterized protein. (261 aa)
asp-4Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
lmtr-5Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (95 aa)
cpl-1Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa)
T08A11.1DEP domain-containing protein. (1872 aa)
vps-39Vacuolar protein sorting-associated protein 39 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on th [...] (926 aa)
T10B10.3Uncharacterized protein. (741 aa)
cpr-3Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
hex-1Beta-hexosaminidase A; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose. (555 aa)
asp-2Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (429 aa)
lbp-8FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
raga-1RAs-related GTP-binding protein A. (312 aa)
T28C6.8Uncharacterized protein. (119 aa)
rab-7RAB family. (209 aa)
asm-3Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (589 aa)
W03G11.3Putative alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family. (482 aa)
haf-4HAlF transporter (PGP related). (787 aa)
dct-11DAF-16/FOXO Controlled, germline Tumor affecting. (236 aa)
vps-18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa)
cpr-8Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
W07B8.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
cpr-5Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
catp-6Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1256 aa)
exc-4Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows. (290 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]