Your Input: | |
| | sid-5 | Systemic RNA interference defective protein 5; Plays a role in RNA-mediated gene silencing by mediating transport of both ingested and endogenous dsRNA between cells. Not required for the uptake of dsRNA from the intestinal lumen. (67 aa) |
| | vps-36 | GLUE N-terminal domain-containing protein. (383 aa) |
| | rme-8 | J domain-containing protein. (2279 aa) |
| | did-2 | Doa4-Independent Degradation, homologous to yeast Did2. (205 aa) |
| | tag-340 | Uncharacterized protein. (447 aa) |
| | vps-41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa) |
| | vha-5 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa) |
| | vps-60 | Related to yeast Vacuolar Protein Sorting factor. (217 aa) |
| | sorf-2 | Suppressor of organelle fusion 2; Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR81 family. (1422 aa) |
| | F52E1.9 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (181 aa) |
| | strl-1 | Steroidogenic acute regulatory-like protein 1. (259 aa) |
| | F55H2.5 | Putative cytochrome b561. (266 aa) |
| | ccz-1 | Uncharacterized protein. (528 aa) |
| | vps-35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (821 aa) |
| | memb-2 | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa) |
| | mig-14 | Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...] (549 aa) |
| | vps-11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] (980 aa) |
| | alx-1 | Apoptosis-linked gene 2-interacting protein X 1; Required for lin-12 degradation after it has been internalised in the vulval precursor cells. (882 aa) |
| | R12C12.5 | Uncharacterized protein. (236 aa) |
| | lmtr-5 | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (95 aa) |
| | vps-39 | Vacuolar protein sorting-associated protein 39 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on th [...] (926 aa) |
| | gna-2 | Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily. (347 aa) |
| | rab-10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa) |
| | T24B8.2 | Charged Multivesicular Body Protein homolog. (411 aa) |
| | vps-24 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | rab-7 | RAB family. (209 aa) |
| | vps-18 | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa) |
| | hmt-1 | Heavy metal tolerance factor 1. (801 aa) |
| | Y25C1A.7 | Yip1 domain-containing protein. (414 aa) |
| | vps-4 | Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. (430 aa) |
| | Y43F8C.11 | Uncharacterized protein. (96 aa) |
| | vps-2 | Related to yeast Vacuolar Protein Sorting factor. (237 aa) |
| | plr-1 | Probable E3 ubiquitin-protein ligase plr-1; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non- canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG. Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the [...] (487 aa) |
| | snx-14 | PXA domain-containing protein. (971 aa) |
| | tat-1 | Phospholipid-transporting ATPase tat-1; Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintainence and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifica [...] (1192 aa) |
| | Y50D4A.4 | Mic1 domain-containing protein. (628 aa) |
| | marc-5 | RING-CH-type domain-containing protein. (470 aa) |
| | vti-1 | t-SNARE coiled-coil homology domain-containing protein. (224 aa) |
| | vps-20 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | Y71H2AM.2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (251 aa) |
| | aex-6 | Rab27. (215 aa) |
| | lmtr-2 | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. (124 aa) |
| | spe-39 | Spermatogenesis-defective protein 39; Proposed to be involved in endosomal maturation implicating in part vps-33.2. May play a role in epithelial polarization through stabilization of apical membrane protein content. May play a role in transcriptional regulation (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. Essential for vesicular trafficking during spermatogenesis; required during spermiogenesis or sperm activation for the morphogenesis of specialized Golgi-derived fibrous body-membran [...] (522 aa) |
| | tbc-2 | TBC (Tre-2/Bub2/Cdc16) domain family. (908 aa) |
| | sorf-1 | Suppressor of organelle fusion 1; Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR91 family. (239 aa) |
| | vps-15 | Related to yeast Vacuolar Protein Sorting factor. (1354 aa) |
| | F13H10.3 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. (617 aa) |
| | ncr-1 | NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family. (1383 aa) |
| | vps-37 | VPS37 C-terminal domain-containing protein. (234 aa) |
| | vps-32.1 | Related to yeast Vacuolar Protein Sorting factor. (221 aa) |
| | vps-33.2 | Vacuolar protein sorting-associated protein 33B; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a rab-5 effector to mediate early endoso [...] (617 aa) |
| | marc-4 | RING-CH-type domain-containing protein. (317 aa) |
| | ilys-3 | Invertebrate-type lysozyme 3; Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria; Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily. (139 aa) |
| | vps-8 | Vps8 domain-containing protein. (1259 aa) |
| | C18F10.7 | ANK_REP_REGION domain-containing protein. (582 aa) |
| | lmtr-3 | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (145 aa) |
| | mvb-12 | MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa) |
| | lmp-2 | LAMP (Lysosome-associated membrane protein) homolog. (296 aa) |
| | vps-16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the la [...] (852 aa) |
| | lmp-1 | LAMP family protein lmp-1; Belongs to the LAMP family. (237 aa) |
| | C01A2.4 | Uncharacterized protein. (207 aa) |
| | vps-33.1 | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE- mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate lat [...] (603 aa) |
| | memb-1 | Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (213 aa) |
