Your Input: | |
| | arp-6 | Actin-like protein C08B11.6; Belongs to the actin family. ARP6 subfamily. (418 aa) |
| | hda-4 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development. (869 aa) |
| | wdr-5.1 | WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...] (376 aa) |
| | smrc-1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. (690 aa) |
| | C17E4.6 | YL1_C domain-containing protein. (391 aa) |
| | xol-1 | XO lethal protein 1; Acts as a primary sex-determining factor that promotes sexual differentiation. Absolutely required for proper sexual differentiation and male viability. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear; Belongs to the GHMP kinase family. Xol-1 subfamily. (426 aa) |
| | swsn-2.2 | SWIB domain-containing protein. (449 aa) |
| | hil-4 | Histone H1.4; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (253 aa) |
| | pqn-15 | Prion-like-(Q/N-rich)-domain-bearing protein. (2171 aa) |
| | sdc-3 | Zinc finger protein sdc-3; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reductio [...] (2150 aa) |
| | C25F9.4 | SNF2_N domain-containing protein. (592 aa) |
| | C25F9.5 | Uncharacterized protein. (713 aa) |
| | dpy-26 | Condensin complex subunit dpy-26; Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners. Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis. As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Plays a role in rob [...] (1263 aa) |
| | pbrm-1 | HMG box domain-containing protein. (1883 aa) |
| | dcp-66 | Deacetylase Complex Protein. (724 aa) |
| | set-2 | Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] (1510 aa) |
| | spr-2 | Suppressor of presenilin-2; Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1. Belongs to the nucleosome assembly protein (NAP) family. (313 aa) |
| | rad-26 | Uncharacterized protein. (1274 aa) |
| | ruvb-1 | RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce- Tor signaling pathway whereby it i [...] (476 aa) |
| | hil-1 | Histone H1.X. (232 aa) |
| | set-4 | Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway. (288 aa) |
| | prmt-5 | Protein arginine N-methyltransferase 5; Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell [...] (734 aa) |
| | sdc-2 | Sex determination and dosage compensation protein sdc-2; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto [...] (2962 aa) |
| | C41G7.3 | Messenger RNA-binding inhibitor of apoptosis 1; RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline. Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline. (393 aa) |
| | ifp-1 | Intermediate filament protein ifp-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (776 aa) |
| | hcf-1 | Host cell factor 1. (782 aa) |
| | C47E8.4 | Protein FAM50 homolog; Belongs to the FAM50 family. (326 aa) |
| | nasp-2 | SHNi-TPR domain-containing protein. (582 aa) |
| | sop-2 | Polycomb protein sop-2; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA. (737 aa) |
| | his-41 | Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa) |
| | hda-1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] (461 aa) |
| | zhit-1 | HIT-type domain-containing protein. (194 aa) |
| | D1053.2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (154 aa) |
| | nap-1 | Nucleosome Assembly Protein; Belongs to the nucleosome assembly protein (NAP) family. (316 aa) |
| | lmn-1 | Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa) |
| | swsn-4 | SWI/SNF nucleosome remodeling complex component. (1474 aa) |
| | lin-28 | Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. (227 aa) |
| | rrf-3 | RNA-dependent RNA polymerase Family. (1765 aa) |
| | ifb-1 | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. (589 aa) |
| | ifb-2 | Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. (577 aa) |
| | F10C1.8 | LTD domain-containing protein. (160 aa) |
| | unc-85 | Probable histone chaperone asf-1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (275 aa) |
| | btf-1 | BTAF (TBP-associated factor) homolog. (1649 aa) |
| | jmjd-3.1 | Lysine-specific demethylase jmjd-3.1; Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell- autonomously in Y-to-PDA tra [...] (1061 aa) |
| | sea-1 | T-box transcription factor 18; Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate. (376 aa) |
| | F19B2.5 | SNF2_N domain-containing protein. (144 aa) |
| | rbbp-5 | Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. (454 aa) |
| | hil-3 | Histone H1.3; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (208 aa) |
| | ifd-2 | Intermediate filament protein ifd-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (443 aa) |
| | let-418 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa) |
| | tam-1 | RING-type domain-containing protein. (944 aa) |
| | nurf-1 | Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. (2197 aa) |
| | jmjd-1.2 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (929 aa) |
| | psr-1 | Bifunctional arginine demethylase and lysyl-hydroxylase psr-1; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. (416 aa) |
| | gsp-1 | Serine/threonine-protein phosphatase PP1-alpha; Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Dephosphorylates translation initiation factor eIF2alpha. Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Belongs to the PPP phosphatase family. PP-1 subfamily. (329 aa) |
| | ada-2 | SANT domain-containing protein. (596 aa) |
| | set-11 | SET (Trithorax/polycomb) domain containing. (367 aa) |
| | isw-1 | Chromatin-remodeling complex ATPase chain isw-1; Energy-transducing component of a NURF-like (nucleosome- remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. (1009 aa) |
| | ifc-1 | Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (500 aa) |
| | ifa-1 | Intermediate filament protein ifa-1; Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis. (592 aa) |
| | hda-6 | Histone deacetylase 6; Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (957 aa) |
| | jmjd-1.1 | JmjC domain-containing protein. (548 aa) |
| | sex-1 | Steroid hormone receptor family member cnr14; Belongs to the nuclear hormone receptor family. NR1 subfamily. (534 aa) |
| | his-39 | Histone domain-containing protein; Belongs to the histone H2B family. (67 aa) |
| | sdc-1 | Zinc finger protein sdc-1; Embryonic transcription factor regulating downstream genes involved specifically in the sex determination and dosage compensation pathways, or regulating other genes involved in the coordinate control of both processes. Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Involved in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodit [...] (1201 aa) |
| | ifa-3 | Intermediate filament protein ifa-3; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures. (581 aa) |
| | dro-1 | CBFD_NFYB_HMF domain-containing protein. (184 aa) |
| | csb-1 | CSB (Cockayne Syndrome B) homolog. (957 aa) |
| | F53H4.6 | Helicase C-terminal domain-containing protein. (933 aa) |
| | spt-4 | Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. (120 aa) |
| | F54E12.2 | Uncharacterized protein. (1091 aa) |
| | zfp-1 | Zinc finger protein zfp-1; Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription. Recognizes and binds histone H3 methylated at 'Lys- 4' (H3K4me) at the promoters of target genes. During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated [...] (867 aa) |
| | dot-1.2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (315 aa) |
| | spt-16 | FACT complex subunit spt-16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...] (1030 aa) |
| | dot-1.4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (383 aa) |
| | gsp-2 | Serine/threonine-protein phosphatase PP1-beta; Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA- mediated genome silencing pathway. Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic matu [...] (333 aa) |
| | F56E10.1 | Uncharacterized protein. (2054 aa) |
| | bet-2 | BET (Two bromodomains) family protein. (1209 aa) |
| | gfi-1 | GEI-4 (Four) Interacting protein. (2153 aa) |
| | wago-4 | Argonaute protein wago-4; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Also interacts with the mRNA targets of 22G-RNAs. Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes. Belongs to the argonaute family. WAGO subfamily. (965 aa) |
| | hil-6 | Putative histone H1.6; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (190 aa) |
| | chd-1 | Chromodomain and Helicase Domain protein. (1461 aa) |
| | athp-2 | AT Hook plus PHD finger transcription factor. (1427 aa) |
| | hpl-2 | Chromo domain-containing protein. (303 aa) |
| | ifa-4 | Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein. (575 aa) |
| | rba-1 | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. (412 aa) |
| | lin-53 | Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repres [...] (417 aa) |
| | rde-1 | RNA interference promoting factor RDE-1. (1020 aa) |
| | hpl-1 | Heterochromatin protein 1 homolog. (184 aa) |
| | hira-1 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (935 aa) |
| | sea-2 | C2H2-type domain-containing protein. (1968 aa) |
| | hat-1 | Hat1_N domain-containing protein. (411 aa) |
| | M03C11.8 | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity). (989 aa) |
| | gfl-1 | GAS41-Like. (211 aa) |
| | M04C3.1 | SNF2_N domain-containing protein. (1162 aa) |
| | M04C3.2 | SNF2_N domain-containing protein. (587 aa) |
| | mix-1 | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] (1244 aa) |
| | his-24 | Histone 24; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (208 aa) |
| | ifc-2 | Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion. (1248 aa) |
| | ifd-1 | Intermediate filament protein ifd-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (575 aa) |
| | met-2 | Histone-lysine N-methyltransferase met-2; Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish betwee [...] (1304 aa) |
| | rfp-1 | E3 ubiquitin-protein ligase bre-1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Belongs to the BRE1 family. (837 aa) |
| | mes-2 | Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] (773 aa) |
| | hda-3 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (465 aa) |
| | snfc-5 | SNF chromatin remodeling Complex component; Belongs to the SNF5 family. (381 aa) |
| | R09A8.2 | Uncharacterized protein. (891 aa) |
| | cbp-1 | Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa) |
| | R10H10.7 | Uncharacterized protein. (915 aa) |
| | dpy-27 | Chromosome condensation protein dpy-27; Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on do [...] (1469 aa) |
| | T01C3.2 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...] (98 aa) |
| | nrde-2 | Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs- mediated silencing in nuclei. Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription. Required for exogenous RNAi-induced H3K27 methylation. Belongs to the NRDE2 family. (1270 aa) |
| | emb-5 | Suppressor of Ty 6 homolog; May regulate transcriptional elongation by RNA polymerase II. Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate; Belongs to the SPT6 family. (1521 aa) |
| | chd-7 | Chromodomain and Helicase Domain protein. (2967 aa) |
| | T05A12.4 | Uncharacterized protein. (1622 aa) |
| | hil-8 | H15 domain-containing protein. (151 aa) |
| | chaf-1 | CHromatin Assembly Factor. (479 aa) |
| | rrp-8 | Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (343 aa) |
| | fox-1 | Sex determination protein fox-1; A member of the sex determination pathway involved in making the distinction between one and two X-chromosomes. RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. Promotes binding of sup-12 to target RNA. (429 aa) |
| | rha-1 | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...] (1301 aa) |
| | lsd-1 | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa) |
| | cec-3 | Chromo domain-containing protein cec-3; Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc- 4 is expressed in the vulval but not in the non-vulval VC neurons. (339 aa) |
| | his-4 | Histone H2B 2. (123 aa) |
| | his-1 | Histone H4. (103 aa) |
| | set-16 | Histone-lysine N-methyltransferase. (2475 aa) |
| | cec-6 | Chromo domain-containing protein. (891 aa) |
| | lin-59 | Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1312 aa) |
| | spat-3 | RING-type domain-containing protein. (2476 aa) |
| | chd-3 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. (1787 aa) |
| | ruvb-2 | RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Has a role in gonadal development. Involved in the en [...] (448 aa) |
| | T23H2.3 | Uncharacterized protein. (1001 aa) |
| | jhdm-1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. (1149 aa) |
| | set-1 | Histone-lysine N-methyltransferase set-1; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily. (242 aa) |
| | T26A5.8 | CBFD_NFYB_HMF domain-containing protein. (137 aa) |
| | lin-40 | Uncharacterized protein. (1022 aa) |
| | jmjc-1 | Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Mediates response to multiple stress stimuli, including heat shock and osmotic, oxidative, and ethanol stress; Belongs to the ROX family. NO66 subfamily. (748 aa) |
| | mys-1 | Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. (458 aa) |
| | dot-1.3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (313 aa) |
| | rad-54 | Uncharacterized protein. (818 aa) |
| | mua-6 | Intermediate filament protein ifa-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle- cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos. (581 aa) |
| | ekl-4 | Uncharacterized protein. (488 aa) |
| | Y105E8B.7 | Uncharacterized protein. (269 aa) |
| | ssl-1 | Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (2395 aa) |
| | Y116A8C.13 | Uncharacterized protein. (833 aa) |
| | bet-1 | Bromodomain-containing protein bet-1; Required for the establishment and maintenance of stable cell fate in several lineages including V5.pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants. Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22. Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells. Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway. I [...] (853 aa) |
| | ash-2 | Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] (575 aa) |
| | mes-4 | Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to [...] (898 aa) |
| | cec-7 | C.Elegans Chromodomain protein. (499 aa) |
| | mrg-1 | MRG domain-containing protein. (337 aa) |
| | dot-1.1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase, which in complex with zfp-1, methylates 'Lys-79' of histone H3 to activate transcription (Probable). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. Involved in controlling tissue-specific gene expression, particularly in the epidermis. (946 aa) |
| | Y40B1A.1 | WW domain-containing protein. (85 aa) |
| | Y40B1A.3 | Uncharacterized protein. (504 aa) |
| | spr-5 | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] (770 aa) |
| | set-23 | Probable histone-lysine N-methyltransferase set-23; Probable histone methyltransferase (By similarity). Required for embryonic development; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (244 aa) |
| | Y43F8B.14 | SNF2_N domain-containing protein. (593 aa) |
| | pcaf-1 | P300/CBP Associated Factor homolog. (767 aa) |
| | jmjd-2 | Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion. (922 aa) |
| | ing-3 | Inhibitor of growth protein. (490 aa) |
| | ppm-1.D | PPM-type phosphatase domain-containing protein. (766 aa) |
| | Y57G11C.9 | RRM domain-containing protein. (625 aa) |
| | chaf-2 | WD_REPEATS_REGION domain-containing protein. (489 aa) |
| | lin-65 | LIN-65L. (728 aa) |
| | swsn-3 | HMG box domain-containing protein. (338 aa) |
| | Y73B6A.1 | Protein kinase domain-containing protein. (414 aa) |
| | hil-2 | Histone H1.2; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (191 aa) |
| | Y75B8A.31 | FAM172 family protein homolog Y75B8A.31; Belongs to the FAM172 family. (313 aa) |
| | dot-1.5 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (361 aa) |
| | ZK1067.2 | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. (2443 aa) |
| | ham-3 | SWIB domain-containing protein. (446 aa) |
| | dve-1 | Homeobox domain-containing protein. (468 aa) |
| | cec-1 | Chromo domain-containing protein cec-1. (304 aa) |
| | sor-1 | Sop-2-related protein 1; Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner. (1000 aa) |
| | his-11 | Histone H2B 1. (122 aa) |
| | rbr-2 | Lysine-specific demethylase rbr-2; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Required for normal longevity of the soma in a germline-dependent manner. Implicated in the epigenetic inheritance of lifespan over several generations. Involved in larval development and vulva formation. (1477 aa) |
| | dpy-30 | Dosage compensation protein dpy-30; Essential for dosage compensation. Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2. Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (123 aa) |
| | B0025.4 | Uncharacterized protein. (148 aa) |
| | his-48 | Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa) |
| | xnp-1 | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. (1359 aa) |
| | air-2 | Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa) |
| | hil-5 | Histone H1.5; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (225 aa) |
| | hil-7 | HIstone H1 Like. (66 aa) |
| | let-526 | ARID domain-containing protein. (1768 aa) |
| | asfl-1 | Probable histone chaperone asf-1-like protein; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (245 aa) |
| | hda-2 | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] (507 aa) |
| | nasp-1 | SHNi-TPR domain-containing protein. (382 aa) |
