STRINGSTRING
crn-4 crn-4 ced-5 ced-5 aex-3 aex-3 snx-1 snx-1 nuc-1 nuc-1 cgh-1 cgh-1 ced-10 ced-10 hda-4 hda-4 akt-1 akt-1 dap-3 dap-3 crn-3 crn-3 crn-5 crn-5 dct-1 dct-1 bcl-7 bcl-7 dpff-1 dpff-1 prmt-5 prmt-5 ced-4 ced-4 brc-1 brc-1 ire-1 ire-1 cps-6 cps-6 eor-2 eor-2 ced-7 ced-7 ced-3 ced-3 uri-1 uri-1 crn-2 crn-2 eat-3 eat-3 ced-8 ced-8 crn-7 crn-7 ttr-52 ttr-52 fis-2 fis-2 F20D6.11 F20D6.11 egl-1 egl-1 vps-41 vps-41 hif-1 hif-1 fis-1 fis-1 ape-1 ape-1 cep-1 cep-1 F54B8.4 F54B8.4 ced-6 ced-6 klf-1 klf-1 dad-1 dad-1 hus-1 hus-1 msh-2 msh-2 dre-1 dre-1 crn-6 crn-6 miro-1 miro-1 dcr-1 dcr-1 cdl-1 cdl-1 ced-13 ced-13 cbp-1 cbp-1 sir-2.1 sir-2.1 eor-1 eor-1 ced-9 ced-9 sav-1 sav-1 gen-1 gen-1 drp-1 drp-1 mtp-18 mtp-18 fem-2 fem-2 scrm-1 scrm-1 hlh-3 hlh-3 dlc-1 dlc-1 cdk-5 cdk-5 T28F4.5 T28F4.5 pig-1 pig-1 ced-12 ced-12 cyn-13 cyn-13 cnt-1 cnt-1 hsp-60 hsp-60 lst-4 lst-4 ndx-4 ndx-4 Y39B6A.34 Y39B6A.34 mrt-2 mrt-2 ced-2 ced-2 rad-51 rad-51 crn-1 crn-1 ced-1 ced-1 csp-3 csp-3 mac-1 mac-1 csp-1 csp-1 atm-1 atm-1 mcd-1 mcd-1 wah-1 wah-1 snx-6 snx-6 csp-2 csp-2 Y77E11A.12 Y77E11A.12 tank-1 tank-1 ced-11 ced-11 ces-2 ces-2
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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crn-4Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing. (298 aa)
ced-5CED-5. (1781 aa)
aex-3MAP kinase-activating death domain protein; Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. Probably by converting rab-3 to its GTP-bound active form, plays a role [...] (1409 aa)
snx-1PX domain-containing protein. (472 aa)
nuc-1Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family. (375 aa)
cgh-1ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (430 aa)
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
hda-4Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development. (869 aa)
akt-1Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] (546 aa)
dap-3Mammalian cell Death Associated Protein related. (375 aa)
crn-3HRDC domain-containing protein. (876 aa)
crn-5RNase_PH domain-containing protein. (214 aa)
dct-1NIP3 homolog; Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth. Required for the induction of mitophagy under stress conditions. Belongs to the NIP3 family. (221 aa)
bcl-7BCL7-like protein; Required for the terminal differentiation of seam cells, and the differentiation of distal tip cells important for normal somatic gonad and germ cell development. Plays a role in the Wnt signaling pathway, regulating the expression of beta-catenin homologs wrm-1, bar- 1 and sys-1, and the localization of wrm-1 and the wnt signaling pathway component pop-1 during asymmetric cell division of seam cells and the Z-cell lineage of the somatic gonad, respectively. May have a pro-apoptotic role, possibly linked to the negative regulation of expression of anti-apoptotic fact [...] (146 aa)
dpff-1Zinc finger protein dpff-1; Belongs to the requiem/DPF family. (372 aa)
prmt-5Protein arginine N-methyltransferase 5; Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell [...] (734 aa)
ced-4Cell death protein 4; Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1. May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway. Regulates CEP neuron apoptosis in response to high Al(3+) levels. During male tail morphogenesis, promotes apoptosis of the tail-spike cell [...] (571 aa)
brc-1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] (612 aa)
ire-1Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa)
cps-6Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. (308 aa)
eor-2EOR-2A. (972 aa)
ced-7ABC transporter ced-7; Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells. (1758 aa)
ced-3Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa)
uri-1URI (Unconventional prefoldin RPB5 Interactor) homolog. (446 aa)
crn-2Cell death-related nuclease 2. (286 aa)
eat-3Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (964 aa)
ced-8Cell death abnormality protein 8; Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses. Belongs to the XK family. (458 aa)
crn-7Cell-death-related nuclease 7; Belongs to the DNase II family. (367 aa)
ttr-52Transthyretin-like protein 52; Plays a role as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1. Important for the generation of extracellular phosphatidylserine vesicles that promote loss of the exoplasmic leaflet from apoptotic cells in a time-dependent manner. Required for the exposure of exoplasmic leaflet on the phagocytic cells surrounding the apoptotic cells. Does not affect the phosphatidylserine externalization in living cells. Ma [...] (135 aa)
fis-2Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa)
F20D6.11Rieske domain-containing protein. (549 aa)
egl-1Programmed cell death activator egl-1; Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9. Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced- 9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis. Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron du [...] (106 aa)
vps-41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa)
hif-1Hypoxia-inducible factor 1; A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureu [...] (721 aa)
fis-1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (143 aa)
ape-1Apoptotic enhancer 1 protein; Negetively regulates apoptosis via its interaction with cep- 1. (769 aa)
cep-1Transcription factor cep-1; Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. Regulates germline apoptosis in response to DNA damage. Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro. Plays a role in cell cycle arrest in the germline in response to DNA damage by UV-C light. However, not required for survival in response to DNA damage induced [...] (644 aa)
F54B8.4Uncharacterized protein. (104 aa)
ced-6Cell death protein 6; May function as an adapter protein in a pathway that mediates recognition and phagocytosis of apoptotic cells during normal development. Promotes engulfment of cells at both early and late stages of apoptosis. Required for actin reorganization around apoptotic cells. Belongs to the ced-6 family. (492 aa)
klf-1Kruppel-Like Factor (Zinc finger protein). (497 aa)
dad-1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across th [...] (113 aa)
hus-1Checkpoint protein. (277 aa)
msh-2DNA_MISMATCH_REPAIR_2 domain-containing protein. (849 aa)
dre-1F-box protein dre-1; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including blmp-1. Heterochronic protein which is required for the timing of gonad development and epidermal seam cell differentiation. Regulates tail-spike cell death through inhibition of the apoptosis regulator ced-9. (1022 aa)
crn-6Cell death-related nuclease 6; Involved in the degradation of chromosomal DNA. Contributes to cell killing; Belongs to the DNase II family. (378 aa)
miro-1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (625 aa)
dcr-1Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa)
cdl-1Histone RNA hairpin-binding protein; Involved in histone pre-mRNA 3' processing. Required for chromosome condensation, progression of cell death and morphogenesis. (382 aa)
ced-13Uncharacterized protein. (98 aa)
cbp-1Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa)
sir-2.1NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] (607 aa)
eor-1EOR-1. (909 aa)
ced-9Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa)
sav-1SAlVador (Cell proliferation regulator) homolog. (389 aa)
gen-1GEN1 Holliday junction resolvase homolog. (434 aa)
drp-1Dynamin-Related Protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa)
mtp-18Mitochondrial fission process protein 1; Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity). Belongs to the MTFP1 family. (166 aa)
fem-2Protein phosphatase fem-2; Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin- dependent protein kinase unc-43/CAMKII in vitro. Involved in the regulation of sex determination. Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes. Promotes apoptosis. Belongs to the PP2C family. (449 aa)
scrm-1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. (295 aa)
hlh-3Helix-loop-helix protein 3; Probable transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Plays a role in the differentiation of the hermaphrodite-specific motor neurons (HSN) that are required for normal egg laying. Might play a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the HSN neurons. Also plays a role in HSN axon guidance towards the vulva and the ventral nerve cord, possibly by promoting the expression of the netrin receptor unc-40. Under f [...] (170 aa)
dlc-1Dynein light chain 1, cytoplasmic; Acts as a non-catalytic accessory component of a dynein complex (By similarity). Part of a complex with bicd-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migrations in hypodermal precursor cells. Probably within a dynein motor complex, plays a role in the cell fate specification of the germline and oogenesis. In particular, it inhibits germ cell proliferation. Regulates the function and localization of the RNA-binding protein fbf- 2 in the germline. P [...] (89 aa)
cdk-5Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] (292 aa)
T28F4.5Uncharacterized protein. (105 aa)
pig-1Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding. (706 aa)
ced-12Cell death abnormality protein 12; Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body. Plays no role in amphid axon outgrowth. (738 aa)
cyn-13Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. (331 aa)
cnt-1Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6. (826 aa)
hsp-60Chaperonin homolog Hsp-60, mitochondrial; Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity). (568 aa)
lst-4Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family. (592 aa)
ndx-4Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. (138 aa)
Y39B6A.34COA8 family protein Y39B6A.34, mitochondrial; May be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain; Belongs to the COA8 family. (142 aa)
mrt-2Cell cycle checkpoint protein RAD1 homolog mrt-2; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break- induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity). Belongs to the Rad1 family. (267 aa)
ced-2Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). (279 aa)
rad-51DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. (395 aa)
crn-1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (382 aa)
ced-1Cell death abnormality protein 1; Involved in programmed cell death, also called apoptosis, in both somatic and germ cells. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria. (1111 aa)
csp-3Non-catalytic caspase homolog csp-3; Non-catalytic caspase homolog which does not contain the region necessary for caspase activity. Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4- induced ced-3 processing. Has no effect on active ced-3. Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development ; Belongs to the peptidase C14A family. (139 aa)
mac-1Protein mac-1; Probably together with ced-9, plays a modest role in preventing ced-4 and caspase ced-3-mediated apoptosis. Belongs to the AAA ATPase family. (813 aa)
csp-1Caspase A subunit p14; Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels. (536 aa)
atm-1Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability. Belongs to the PI3/PI4-kinase family. ATM subfamily. (2378 aa)
mcd-1Modifier of cell death; Promotes programmed cell death. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins dpl-1 and lin-35, and is independent of the ced-1, ced-8 and ced-9 pathways. (901 aa)
wah-1Worm AIF (Apoptosis inducing factor) Homolog. (700 aa)
snx-6PX domain-containing protein. (478 aa)
csp-2Putative inactive caspase B subunit p17; [Isoform b]: Putative inactive caspase. In the germline, binds caspase ced-3 zymogen and prevents ced-3 autoactivation. Does not affect the caspase activity of mature ced-3 and ced-4-mediated mature ced-3 activation. Negatively regulates germline apoptosis by inhibiting autocleavage of caspase ced-3. Involved in fertility ; Belongs to the peptidase C14A family. (826 aa)
Y77E11A.12GRAM domain-containing protein. (644 aa)
tank-1Poly [ADP-ribose] polymerase tankyrase; Poly[ADP-ribose] polymerases modify various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death. (2276 aa)
ced-11Protein ced-11; Plays a major role in programmed cell death. (1418 aa)
ces-2Cell death specification protein 2; Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes. Binds to the DNA sequence 5'-RTTACGTAAY-3'; Belongs to the bZIP family. (211 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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