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ani-1 ani-1 rho-1 rho-1 tag-273 tag-273 Y57G11C.1147 Y57G11C.1147 eps-8 eps-8 hum-8 hum-8 fln-1 fln-1 arx-4 arx-4 arx-1 arx-1 Y71H2AM.12 Y71H2AM.12 Y73B3B.1 Y73B3B.1 pod-1 pod-1 arx-3 arx-3 frg-1 frg-1 hipr-1 hipr-1 zoo-1 zoo-1 lev-11 lev-11 ced-12 ced-12 crp-1 crp-1 arx-5 arx-5 cdap-2 cdap-2 pfn-2 pfn-2 hum-2 hum-2 twf-2 twf-2 cas-1 cas-1 hum-4 hum-4 ipla-2 ipla-2 spe-15 spe-15 unc-60-2 unc-60-2 pat-10 pat-10 hum-7 hum-7 exc-6 exc-6 ric-7 ric-7 ddl-1 ddl-1 syg-1 syg-1 rac-2 rac-2 pfn-3 pfn-3 gsnl-1 gsnl-1 arx-2 arx-2 aipl-1 aipl-1 arx-7 arx-7 cor-1 cor-1 wve-1 wve-1 hum-5 hum-5 T05E7.3 T05E7.3 ced-9 ced-9 hum-6 hum-6 ttc-17 ttc-17 rsf-1 rsf-1 W02H5.2 W02H5.2 ipla-3 ipla-3 plst-1 plst-1 hum-1 hum-1 gex-3 gex-3 egl-1 egl-1 inft-2 inft-2 cyk-1 cyk-1 F10G8.8 F10G8.8 tth-1 tth-1 unc-87 unc-87 tag-138 tag-138 ced-3 ced-3 C46H11.3 C46H11.3 fhod-1 fhod-1 nab-1 nab-1 unc-60 unc-60 ced-4 ced-4 arx-6 arx-6 mig-2 mig-2 viln-1 viln-1 ced-10 ced-10 tmd-2 tmd-2 wsp-1 wsp-1 unc-94 unc-94 unc-78 unc-78 erm-1 erm-1 fli-1 fli-1 abi-1 abi-1 ddl-2 ddl-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ani-1Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa)
rho-1Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa)
tag-273LIM zinc-binding domain-containing protein. (891 aa)
Y57G11C.1147Uncharacterized protein. (74 aa)
eps-8SH3 domain-containing protein. (942 aa)
hum-8Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1279 aa)
fln-1Calponin-homology (CH) domain-containing protein. (2259 aa)
arx-4Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa)
arx-1Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (425 aa)
Y71H2AM.12Uncharacterized protein. (195 aa)
Y73B3B.1Calponin-homology (CH) domain-containing protein. (376 aa)
pod-1Uncharacterized protein. (1136 aa)
arx-3Actin-related protein 2/3 complex subunit. (375 aa)
frg-1Protein FRG1 homolog; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B (By similarity); Belongs to the FRG1 family. (274 aa)
hipr-1Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family. (927 aa)
zoo-1ZO-1 (Zonula Occludens tight junctional protein) Ortholog. (1172 aa)
lev-11Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa)
ced-12Cell death abnormality protein 12; Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body. Plays no role in amphid axon outgrowth. (738 aa)
crp-1Cdc-42 Related Protein. (187 aa)
arx-5Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa)
cdap-2CD2AP homolog. (551 aa)
pfn-2Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (131 aa)
hum-2Dilute domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1811 aa)
twf-2TWinFilin actin binding protein homolog. (333 aa)
cas-1Adenylyl cyclase-associated protein; Belongs to the CAP family. (1256 aa)
hum-4Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2581 aa)
ipla-2Intracelllar PhosphoLipase A family. (1071 aa)
spe-15Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1219 aa)
unc-60-2Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa)
pat-10Paralysed Arrest at Two-fold. (161 aa)
hum-7Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa)
exc-6Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa)
ric-7Uncharacterized protein. (709 aa)
ddl-1WASH complex subunit homolog 3; Belongs to the CCDC53 family. (189 aa)
syg-1Synaptogenesis protein syg-1; Cell adhesion protein. Involved in synapse formation in the HSNL egg-laying motor neuron. Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination. Also required for F- actin assembly at the synaptic region and for axon branch formation. (730 aa)
rac-2Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation. (195 aa)
pfn-3Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. (126 aa)
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. (475 aa)
arx-2Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (395 aa)
aipl-1WD_REPEATS_REGION domain-containing protein. (600 aa)
arx-7Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
cor-1Coronin-like protein cor-1; Required to direct the migration of Q neuroblasts along the anterior axis of the body during larval development. This is dependent on its asymmetric expression in Q neuroblasts. Belongs to the WD repeat coronin family. (607 aa)
wve-1WH2 domain-containing protein. (468 aa)
hum-5Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1017 aa)
T05E7.3Uncharacterized protein. (997 aa)
ced-9Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa)
hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (2098 aa)
ttc-17TeTratriCopeptide repeat domain protein related. (1280 aa)
rsf-1RASSF (Ras-association domain family) homolog. (615 aa)
W02H5.2Uncharacterized protein. (620 aa)
ipla-3Intracelllar PhosphoLipase A family. (1047 aa)
plst-1PLaSTin (Actin bundling protein) homolog. (370 aa)
hum-1Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1100 aa)
gex-3Membrane-associated protein gex-3; Rac effector required for tissue morphogenesis, cell migrations and egg laying. May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. (1141 aa)
egl-1Programmed cell death activator egl-1; Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9. Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced- 9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis. Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron du [...] (106 aa)
inft-2FH2 domain-containing protein. (1120 aa)
cyk-1CYtoKinesis defect. (1437 aa)
F10G8.8Uncharacterized protein. (984 aa)
tth-1Thymosin beta; Plays an important role in the organization of the cytoskeleton by regulating actin polymerization in two ways. Firstly, by binding to and sequestering actin monomers (G actin) inhibits actin polymerization. Secondly, by binding directly filamentous actin (F actin) promotes actin polymerization. Regulates the formation of cortical actin in oocytes conferring them enough rigidity to sustain the contractions during ovulation. (151 aa)
unc-87Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa)
tag-138ENTH domain-containing protein. (362 aa)
ced-3Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa)
C46H11.3Probable actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (146 aa)
fhod-1Formin HOmology Domain. (1698 aa)
nab-1NeurABin. (721 aa)
unc-60Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa)
ced-4Cell death protein 4; Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1. May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway. Regulates CEP neuron apoptosis in response to high Al(3+) levels. During male tail morphogenesis, promotes apoptosis of the tail-spike cell [...] (571 aa)
arx-6Probable actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (169 aa)
mig-2Rac-like GTPase. (195 aa)
viln-1HP domain-containing protein. (918 aa)
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
tmd-2TropoMoDulin. (639 aa)
wsp-1WASP (Actin cytoskeleton modulator) homolog. (781 aa)
unc-94Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa)
unc-78Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa)
erm-1FERM domain-containing protein. (564 aa)
fli-1Protein flightless-1 homolog; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. (1257 aa)
abi-1SH3 domain-containing protein. (469 aa)
ddl-2WASH_WAHD domain-containing protein. (497 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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