STRINGSTRING
C01A2.4 C01A2.4 snpn-1 snpn-1 mvb-12 mvb-12 tsg-101 tsg-101 stg-1 stg-1 C25H3.11 C25H3.11 vps-51 vps-51 vps-22 vps-22 C30B5.2 C30B5.2 vha-16 vha-16 gop-1 gop-1 stam-1 stam-1 vps-8 vps-8 vps-32.1 vps-32.1 CD4.11 CD4.11 vps-37 vps-37 vps-52 vps-52 vps-36 vps-36 did-2 did-2 vps-41 vps-41 vps-60 vps-60 sand-1 sand-1 K11H3.4 K11H3.4 R12C12.5 R12C12.5 cup-5 cup-5 T08G11.1 T08G11.1 bec-1 bec-1 vps-54 vps-54 T23G11.7 T23G11.7 T24B8.2 T24B8.2 vps-24 vps-24 vps-25 vps-25 rab-7 rab-7 haf-4 haf-4 vps-18 vps-18 apd-3 apd-3 apg-1 apg-1 vps-2 vps-2 ego-2 ego-2 arl-8 arl-8 vti-1 vti-1 vps-20 vps-20 Y74C10AL.2 Y74C10AL.2 vps-28 vps-28 spe-39 spe-39 haf-9 haf-9 ZK632.12 ZK632.12 vps-15 vps-15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C01A2.4Uncharacterized protein. (207 aa)
snpn-1SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the SNAPIN family. (122 aa)
mvb-12MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa)
tsg-101Tumor Susceptibility Gene homolog. (425 aa)
stg-1STarGazin (Mammalian calcium channel) homolog. (366 aa)
C25H3.11Ricin B-type lectin domain-containing protein. (3314 aa)
vps-51Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS51 family. (700 aa)
vps-22Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (269 aa)
C30B5.2Vacuolar protein sorting-associated protein 55 homolog; Involved in endosomal protein transport. (132 aa)
vha-16V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (348 aa)
gop-1Protein CLEC16A homolog; Regulator of mitophagy. (892 aa)
stam-1Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa)
vps-8Vps8 domain-containing protein. (1259 aa)
vps-32.1Related to yeast Vacuolar Protein Sorting factor. (221 aa)
CD4.11Uncharacterized protein. (496 aa)
vps-37VPS37 C-terminal domain-containing protein. (234 aa)
vps-52Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS52 family. (702 aa)
vps-36GLUE N-terminal domain-containing protein. (383 aa)
did-2Doa4-Independent Degradation, homologous to yeast Did2. (205 aa)
vps-41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa)
vps-60Related to yeast Vacuolar Protein Sorting factor. (217 aa)
sand-1SAND endocytosis protein family. (459 aa)
K11H3.4Uncharacterized protein K11H3.4. (364 aa)
R12C12.5Uncharacterized protein. (236 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
T08G11.1Uncharacterized protein. (3212 aa)
bec-1Beclin homolog; Regulates autophagy. Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate (PtdIns3P), thereby regulating membrane trafficking. In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3- phosphate in early endosomes to allow for the conversion to late endosomes. Involved in the clearance of engulfed apoptotic cell corpses. Together with ced-9, negatively regulates somatic and germline apoptosis. Plays a role in endosome-to-Golgi retrograde tra [...] (375 aa)
vps-54Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. (1058 aa)
T23G11.7Uncharacterized protein. (361 aa)
T24B8.2Charged Multivesicular Body Protein homolog. (411 aa)
vps-24Related to yeast Vacuolar Protein Sorting factor. (208 aa)
vps-25Related to yeast Vacuolar Protein Sorting factor. (183 aa)
rab-7RAB family. (209 aa)
haf-4HAlF transporter (PGP related). (787 aa)
vps-18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa)
apd-3AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa)
apg-1AP-1 complex subunit gamma. (829 aa)
vps-2Related to yeast Vacuolar Protein Sorting factor. (237 aa)
ego-2BRO1 domain-containing protein. (1494 aa)
arl-8Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. (185 aa)
vti-1t-SNARE coiled-coil homology domain-containing protein. (224 aa)
vps-20Related to yeast Vacuolar Protein Sorting factor. (208 aa)
Y74C10AL.2Uncharacterized protein. (157 aa)
vps-28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa)
spe-39Spermatogenesis-defective protein 39; Proposed to be involved in endosomal maturation implicating in part vps-33.2. May play a role in epithelial polarization through stabilization of apical membrane protein content. May play a role in transcriptional regulation (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. Essential for vesicular trafficking during spermatogenesis; required during spermiogenesis or sperm activation for the morphogenesis of specialized Golgi-derived fibrous body-membran [...] (522 aa)
haf-9ABC transmembrane type-1 domain-containing protein. (815 aa)
ZK632.12Uncharacterized protein ZK632.12. (266 aa)
vps-15Related to yeast Vacuolar Protein Sorting factor. (1354 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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