STRINGSTRING
rab-14 rab-14 cln-3.2 cln-3.2 snpn-1 snpn-1 snx-1 snx-1 ril-2 ril-2 aexr-2 aexr-2 ctns-1 ctns-1 cln-3.1 cln-3.1 mrp-4 mrp-4 cup-15 cup-15 unc-108 unc-108 apm-3 apm-3 ccz-1 ccz-1 glo-1 glo-1 vha-1 vha-1 apb-3 apb-3 cup-5 cup-5 umps-1 umps-1 rab-7 rab-7 vps-18 vps-18 lst-4 lst-4 ced-1 ced-1 vha-13 vha-13 tat-1 tat-1 cup-14 cup-14 snx-6 snx-6 cln-3.3 cln-3.3 vha-9 vha-9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rab-14RAB family. (210 aa)
cln-3.2Battenin. (435 aa)
snpn-1SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the SNAPIN family. (122 aa)
snx-1PX domain-containing protein. (472 aa)
ril-2RNAi-Induced Longevity. (677 aa)
aexr-2G_PROTEIN_RECEP_F1_2 domain-containing protein. (415 aa)
ctns-1Cystinosin homolog; Thought to transport cystine out of lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells. (404 aa)
cln-3.1Battenin. (424 aa)
mrp-4Uncharacterized protein. (1573 aa)
cup-15Coelomocyte uptake defective protein 15; Modulates the transport of substances from the endosomal to lysosomal compartments. Plays a role in lysosome formation and function in coelomocytes. (322 aa)
unc-108Uncharacterized protein. (223 aa)
apm-3MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (414 aa)
ccz-1Uncharacterized protein. (528 aa)
glo-1Gut granule LOss. (212 aa)
vha-1V-type proton ATPase 16 kDa proteolipid subunit 1; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-AT [...] (169 aa)
apb-3AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (945 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
umps-1Orotidine 5'-phosphate decarboxylase; Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis. May also form UMP from uracil. Regulates the size of gut granules during embryonic development. Involved in resistance to DNA damaging agents including UV-C and X-ray radiation. In the C-terminal section; belongs to the OMP decarboxylase family. (497 aa)
rab-7RAB family. (209 aa)
vps-18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa)
lst-4Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family. (592 aa)
ced-1Cell death abnormality protein 1; Involved in programmed cell death, also called apoptosis, in both somatic and germ cells. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria. (1111 aa)
vha-13V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (Probable). V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-A [...] (606 aa)
tat-1Phospholipid-transporting ATPase tat-1; Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintainence and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifica [...] (1192 aa)
cup-14RUN domain-containing protein. (955 aa)
snx-6PX domain-containing protein. (478 aa)
cln-3.3Battenin. (417 aa)
vha-9Probable V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function (Probable). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of [...] (121 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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