STRINGSTRING
mvb-12 mvb-12 rab-7 rab-7 cup-5 cup-5 K11H3.4 K11H3.4 sand-1 sand-1 vps-52 vps-52 stam-1 stam-1 gop-1 gop-1 stg-1 stg-1 tsg-101 tsg-101 haf-4 haf-4 snpn-1 snpn-1 vps-51 vps-51 ZK632.12 ZK632.12 haf-9 haf-9 arl-8 arl-8 apd-3 apd-3 vps-18 vps-18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mvb-12MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa)
rab-7RAB family. (209 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
K11H3.4Uncharacterized protein K11H3.4. (364 aa)
sand-1SAND endocytosis protein family. (459 aa)
vps-52Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS52 family. (702 aa)
stam-1Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa)
gop-1Protein CLEC16A homolog; Regulator of mitophagy. (892 aa)
stg-1STarGazin (Mammalian calcium channel) homolog. (366 aa)
tsg-101Tumor Susceptibility Gene homolog. (425 aa)
haf-4HAlF transporter (PGP related). (787 aa)
snpn-1SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the SNAPIN family. (122 aa)
vps-51Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS51 family. (700 aa)
ZK632.12Uncharacterized protein ZK632.12. (266 aa)
haf-9ABC transmembrane type-1 domain-containing protein. (815 aa)
arl-8Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. (185 aa)
apd-3AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa)
vps-18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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