STRINGSTRING
sma-3 sma-3 grd-1 grd-1 cog-1 cog-1 pdi-3 pdi-3 grd-2 grd-2 ram-2 ram-2 mab-21 mab-21 vab-3 vab-3 sin-3 sin-3 dex-1 dex-1 smp-2 smp-2 ptr-4 ptr-4 dyf-7 dyf-7 mls-2 mls-2 grd-8 grd-8 ptr-2 ptr-2 eff-1 eff-1 ptr-1 ptr-1 die-1 die-1 mab-5 mab-5 grd-9 grd-9 wrt-4 wrt-4 sma-2 sma-2 ptr-23 ptr-23 wrt-1 wrt-1 mab-20 mab-20 plx-1 plx-1 smp-1 smp-1 ptr-20 ptr-20 grdn-1 grdn-1 ptr-18 ptr-18 spd-1 spd-1 rab-28 rab-28 lin-32 lin-32 hum-6 hum-6 qua-1 qua-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sma-3Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family. (393 aa)
grd-1GRounDhog (Hedgehog-like family). (1160 aa)
cog-1Homeobox domain-containing protein. (256 aa)
pdi-3Protein disulfide-isomerase. (488 aa)
grd-2GRounDhog (Hedgehog-like family). (946 aa)
ram-2Col_cuticle_N domain-containing protein. (306 aa)
mab-21Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. Belongs to the mab-21 family. (364 aa)
vab-3Homeobox domain-containing protein. (455 aa)
sin-3Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). (1507 aa)
dex-1Dendrite extension defective protein 1; Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. (1137 aa)
smp-2Sema domain-containing protein; Belongs to the semaphorin family. (649 aa)
ptr-4SSD domain-containing protein. (960 aa)
dyf-7Protein dyf-7; Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development. (446 aa)
mls-2Homeobox domain-containing protein. (341 aa)
grd-8Ground-like domain-containing protein. (373 aa)
ptr-2SSD domain-containing protein. (933 aa)
eff-1Epithelial Fusion Failure. (658 aa)
ptr-1SSD domain-containing protein. (956 aa)
die-1C2H2-type domain-containing protein. (646 aa)
mab-5Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family. (200 aa)
grd-9Ground-like domain-containing protein. (588 aa)
wrt-4Warthog protein 4 C-product; Intercellular signal essential for a variety of patterning events during development. (557 aa)
sma-2Dwarfin sma-2; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis. (418 aa)
ptr-23SSD domain-containing protein. (983 aa)
wrt-1Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. (484 aa)
mab-20Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] (658 aa)
plx-1Sema domain-containing protein. (1956 aa)
smp-1Semaphorin-1A; May function in growth cone guidance; Belongs to the semaphorin family. (712 aa)
ptr-20SSD domain-containing protein. (860 aa)
grdn-1Girdin homolog; Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI and the phasmid neurons PHA and PHB. Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10. Belongs to the CCDC88 family. (1319 aa)
ptr-18SSD domain-containing protein. (895 aa)
spd-1SPD-1. (529 aa)
rab-28Ras-related protein Rab-28; GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons. Belongs to the small GTPase superfamily. Rab family. (248 aa)
lin-32Protein lin-32; Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs. Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis. (142 aa)
hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (2098 aa)
qua-1Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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