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stg-2 | STarGazin (Mammalian calcium channel) homolog. (379 aa) | ||||
glc-1 | Glutamate-gated chloride channel alpha; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. P [...] (461 aa) | ||||
unc-98 | Zinc finger protein unc-98; Probable transcription factor required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (310 aa) | ||||
nmr-1 | NMDA-type ionotropic glutamate receptor NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1025 aa) | ||||
flp-9 | FMRFamide-like neuropeptides 9; FMRFamides and FMRFamide-like peptides are neuropeptides. Belongs to the FARP (FMRFamide related peptide) family. (102 aa) | ||||
prmt-5 | Protein arginine N-methyltransferase 5; Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell [...] (734 aa) | ||||
dyc-1 | Dystrophin-like protein 1; Together with dys-1 and hlh-1, participates in a common muscular function. (887 aa) | ||||
hpo-9 | BTB domain-containing protein. (581 aa) | ||||
bas-1 | Biogenic Amine Synthesis related. (523 aa) | ||||
lnp-1 | Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1; Belongs to the lunapark family. (346 aa) | ||||
glr-1 | Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa) | ||||
pdfr-1 | Calcitonin receptor-like protein 1; G-protein coupled receptor for PDF neuropeptides. Activated by peptides PDF-1 and PDF-2 but to a lesser extent with isoform c. Isoforms a and b are thought to act through the G-alpha(s) type of G proteins to elevate cAMP levels whereas isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. Involved in locomotion; more specifically mate searching behavior independent of nutritional status. Might have a role in touch sensitivity. (546 aa) | ||||
lite-1 | High-energy light unresponsive protein 1; Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. (439 aa) | ||||
sol-1 | Suppressor of lurcher protein 1; Accessory protein required for glutamate-gated currents. May participate in the gating of non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors such as glr-1. (594 aa) | ||||
seb-3 | Secretin receptor-like protein SEB-3; Belongs to the G-protein coupled receptor 2 family. (454 aa) | ||||
unc-31 | Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by sat [...] (1401 aa) | ||||
unc-22 | Twitchin; Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces. Plays a role in the organization of sarcomeres in body wall muscles ; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (7158 aa) | ||||
eat-4 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa) | ||||
glc-3 | Glutamate-gated chloride channel subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa) | ||||
nipa-1 | NIPA1 (NonImprinted gene in Prader-Willi/Angelman syndrome region 1) homolog. (397 aa) | ||||
osm-5 | OSM-5. (820 aa) | ||||
rab-28 | Ras-related protein Rab-28; GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons. Belongs to the small GTPase superfamily. Rab family. (248 aa) | ||||
rab-6.2 | Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa) | ||||
unc-49 | Ionotropic GABA receptor subunit UNC-49B.3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (506 aa) | ||||
dop-3 | Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1. (607 aa) | ||||
srx-43 | Serpentine receptor class X-43; Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior. Belongs to the G-protein coupled receptor 1 family. (319 aa) | ||||
unc-10 | Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...] (1563 aa) | ||||
pdf-1 | PDF (Arthropod Pigment Dispersing Factor) homolog. (88 aa) | ||||
unc-2 | EF-hand domain-containing protein. (2171 aa) | ||||
avr-15 | Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (657 aa) | ||||
vab-15 | Homeobox protein vab-15; Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis. (225 aa) | ||||
myo-3 | Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa) | ||||
mak-1 | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (521 aa) | ||||
syd-2 | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. (1139 aa) | ||||
fax-1 | Nuclear receptor domain-containing protein. (419 aa) | ||||
nlp-37 | PDF (Arthropod Pigment Dispersing Factor) homolog. (89 aa) | ||||
dyb-1 | Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. (590 aa) | ||||
snt-1 | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa) | ||||
flp-1 | FMRFamide-like neuropeptides 1; Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (175 aa) | ||||
dys-1 | Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa) | ||||
avr-14 | Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa) |