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| | Y57G11C.22 | Uncharacterized protein. (444 aa) |
| | che-12 | Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa) |
| | casy-1 | CAlSYntenin/Alcadein homolog. (984 aa) |
| | znf-207 | BED-type domain-containing protein. (341 aa) |
| | air-2 | Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa) |
| | rmd-3 | Regulator of Microtubule Dynamics. (225 aa) |
| | fli-1 | Protein flightless-1 homolog; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. (1257 aa) |
| | unc-76 | Uncharacterized protein. (388 aa) |
| | erm-1 | FERM domain-containing protein. (564 aa) |
| | dyn-1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa) |
| | knl-1 | Kinetochore null protein 1; Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division. Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy. Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores. Required for the recruitment of spindle-assembly checkpoint comp [...] (1010 aa) |
| | dyf-11 | Uncharacterized protein. (535 aa) |
| | unc-78 | Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa) |
| | vps-16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the la [...] (852 aa) |
| | unc-94 | Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family. (401 aa) |
| | C06E1.1 | Uncharacterized protein C06E1.1. (161 aa) |
| | klp-18 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (932 aa) |
| | C07A9.5 | Uncharacterized calcium-binding protein C07A9.5. (358 aa) |
| | wsp-1 | WASP (Actin cytoskeleton modulator) homolog. (781 aa) |
| | cls-1 | Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (By similarity). Operates redundantly with cls-2 and cls-3 in regulating microtubule processes which position the spindle during asymmetric cell division. (1378 aa) |
| | tmd-2 | TropoMoDulin. (639 aa) |
| | viln-1 | HP domain-containing protein. (918 aa) |
| | kca-1 | Kinesin 1 cargo adaptor alternative variant a. (407 aa) |
| | C13A2.12 | Uncharacterized protein. (258 aa) |
| | tnt-3 | TropoNin T. (1178 aa) |
| | C16C8.18 | Uncharacterized protein. (270 aa) |
| | rab-3 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa) |
| | klc-2 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. (540 aa) |
| | cas-2 | Adenylyl cyclase-associated protein; Belongs to the CAP family. (457 aa) |
| | sax-7 | Fibronectin type-III domain-containing protein. (1331 aa) |
| | ift-74 | IFT (Chlamydomonas IntraFlagellar Transport) homolog. (624 aa) |
| | fln-2 | FiLamiN (Actin binding protein) homolog. (3672 aa) |
| | spas-1 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. (512 aa) |
| | ajm-1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. (1905 aa) |
| | rmd-2 | TPR_REGION domain-containing protein. (378 aa) |
| | pxl-1 | Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. (413 aa) |
| | tppp-1 | Tubulin polymerization-promoting protein homolog; Regulator of microtubule dynamics. (180 aa) |
| | maph-9 | Protein maph-9. (512 aa) |
| | arx-6 | Probable actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (169 aa) |
| | maph-1.3 | Microtubule-Associated Protein Homolog. (874 aa) |
| | C36B1.14 | Uncharacterized protein. (99 aa) |
| | mlc-1 | Myosin regulatory light chain 1. (170 aa) |
| | mlc-2 | Myosin regulatory light chain 2. (170 aa) |
| | unc-60 | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa) |
| | klp-16 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (587 aa) |
| | nab-1 | NeurABin. (721 aa) |
| | bicd-1 | Protein bicaudal D homolog; Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (Probable). Required for the formation of dendritic branches of PVD sensory neurons ; Belongs to the BicD family. (737 aa) |
| | fhod-1 | Formin HOmology Domain. (1698 aa) |
| | C46H11.3 | Probable actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (146 aa) |
| | gasr-8 | GAS (Human Growth Arrest-Specific) Related. (410 aa) |
| | ptp-1 | Tyrosine-protein phosphatase 1. (1026 aa) |
| | C50C3.2 | Uncharacterized protein C50C3.2; Belongs to the spectrin family. (2236 aa) |
| | C50C3.5 | Uncharacterized calcium-binding protein C50C3.5. (189 aa) |
| | coel-1 | Tubulin folding COfactor E-Like protein. (432 aa) |
| | unc-104 | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] (1628 aa) |
| | ttll-5 | Tubulin polyglutamylase ttll-5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating. Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons. (730 aa) |
| | mlc-4 | Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity. (172 aa) |
| | eat-3 | Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (964 aa) |
| | cap-1 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa) |
| | maco-1 | Macoilin; Plays a role in the regulation of neuronal activity. (897 aa) |
| | D2096.11 | GAR domain-containing protein. (727 aa) |
| | unc-15 | Paramyosin; Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. Belongs to the paramyosin family. (872 aa) |
| | tag-138 | ENTH domain-containing protein. (362 aa) |
| | unc-87 | Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress. (565 aa) |
| | unc-98 | Zinc finger protein unc-98; Probable transcription factor required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (310 aa) |
| | tth-1 | Thymosin beta; Plays an important role in the organization of the cytoskeleton by regulating actin polymerization in two ways. Firstly, by binding to and sequestering actin monomers (G actin) inhibits actin polymerization. Secondly, by binding directly filamentous actin (F actin) promotes actin polymerization. Regulates the formation of cortical actin in oocytes conferring them enough rigidity to sustain the contractions during ovulation. (151 aa) |
| | kap-1 | Kinesin-Associated Protein. (696 aa) |
| | unc-115 | Uncharacterized protein. (639 aa) |
| | pes-7 | Patterned Expression Site. (1391 aa) |
| | F09C6.1 | Uncharacterized protein. (226 aa) |
| | F10G8.8 | Uncharacterized protein. (984 aa) |
| | unc-54 | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) |
| | cyk-1 | CYtoKinesis defect. (1437 aa) |
| | unc-96 | Uncharacterized protein. (418 aa) |
| | rhgf-1 | RHo Guanine nucleotide exchange Factor. (1340 aa) |
| | unc-97 | LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons. (348 aa) |
| | dys-1 | Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa) |
| | tbcd-1 | Tubulin-specific chaperone D; Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization ; Belongs to the TBCD family. (1232 aa) |
| | nlr-1 | Neurexin Like receptor. (1180 aa) |
| | klp-11 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (782 aa) |
| | nmy-2 | Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2003 aa) |
| | zyg-9 | Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. (1415 aa) |
| | inx-3 | Innexin-3; Structural component of the gap junctions. Belongs to the pannexin family. (420 aa) |
| | klp-13 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (691 aa) |
| | bmk-1 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa) |
| | ttll-9 | Probable tubulin polyglutamylase ttll-9; Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth. (417 aa) |
| | maph-1.2 | Microtubule-Associated Protein Homolog. (874 aa) |
| | F26H9.2 | Uncharacterized protein. (508 aa) |
| | lim-8 | LIM domain family. (1099 aa) |
| | hum-1 | Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1100 aa) |
| | ift-81 | IFT81_CH domain-containing protein. (638 aa) |
| | maph-1.1 | Microtubule-associated protein homolog maph-1.1; Belongs to the MAP1A/MAP1B/MAP1S family. (878 aa) |
| | figl-1 | Fidgetin-like protein 1; Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis. Required for fertility. (594 aa) |
| | itr-1 | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa) |
| | F33H2.6 | TPR_REGION domain-containing protein. (301 aa) |
| | ptrn-1 | Patronin (microtubule-binding protein) homolog; Required for microtubule stability and anchorage by binding to the minus ends of microtubules. Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis. Promotes microtubule stability and polymerization in neurons. Involved in the maintenance of neurite morphology in ALM and PLM neurons. May play a role in synaptic protein localization in the PLM neuron. May act upstream of dlk-1 in neuronal regeneration. Play [...] (1112 aa) |
| | pfn-2 | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (131 aa) |
| | hum-2 | Dilute domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1811 aa) |
| | F36F2.1 | Costars domain-containing protein. (162 aa) |
| | elp-1 | Echinoderm microtubule-associated protein-like elp-1; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. (891 aa) |
| | twf-2 | TWinFilin actin binding protein homolog. (333 aa) |
| | add-1 | Adducin-related protein 1; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. (732 aa) |
| | cas-1 | Adenylyl cyclase-associated protein; Belongs to the CAP family. (1256 aa) |
| | nfm-1 | FERM domain-containing protein. (709 aa) |
| | tni-1 | Troponin I 1; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (250 aa) |
| | ptl-1 | Microtubule-associated protein. (458 aa) |
| | F42H10.3 | LIM and SH3 domain protein F42H10.3. (335 aa) |
| | unc-53 | Adapter protein unc-53; Involved in the migration and outgrowth of muscles, axons and excretory canals. (1654 aa) |
| | myo-6 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1235 aa) |
| | hum-4 | Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2581 aa) |
| | ipla-2 | Intracelllar PhosphoLipase A family. (1071 aa) |
| | F47G4.5 | Uncharacterized protein. (280 aa) |
| | dyb-1 | Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. (590 aa) |
| | spe-15 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1219 aa) |
| | nmy-1 | Non-muscle MYosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) |
| | tnt-2 | TropoNin T. (428 aa) |
| | unc-60-2 | Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa) |
| | F54A3.2 | Uncharacterized protein. (748 aa) |
| | pat-10 | Paralysed Arrest at Two-fold. (161 aa) |
| | ketn-1 | KETtiN (Drosophila actin-binding) homolog. (4963 aa) |
| | F54F2.7 | Uncharacterized protein F54F2.7. (157 aa) |
| | hum-7 | Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa) |
| | daam-1 | FH2 domain-containing protein. (987 aa) |
| | klp-4 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1610 aa) |
| | lgl-1 | LLGL domain-containing protein. (941 aa) |
| | mei-2 | Meiotic spindle formation protein 2; Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germline. (280 aa) |
| | add-2 | Adducin-related protein 2; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network; Belongs to the aldolase class II family. Adducin subfamily. (611 aa) |
| | exc-6 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa) |
| | par-2 | RING-type domain-containing protein. (582 aa) |
| | myo-5 | MYOsin heavy chain structural genes; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa) |
| | syd-2 | Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily. (1139 aa) |
| | H03A11.2 | Uncharacterized protein. (1218 aa) |
| | gip-1 | Gamma-tubulin complex component. (963 aa) |
| | frm-3 | FERM domain-containing protein. (1091 aa) |
| | ttll-11 | Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...] (707 aa) |
| | par-1 | Serine/threonine-protein kinase par-1; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis. Involved in the establishment of neuronal polarity. (1216 aa) |
| | H39E23.3 | Uncharacterized protein. (746 aa) |
| | fozi-1 | Formin-homology and zinc finger domains protein 1; Acts redundantly with hlh-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2; Belongs to the formin homology family. (732 aa) |
| | pfn-3 | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. (126 aa) |
| | apr-1 | Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing [...] (1188 aa) |
| | gsnl-1 | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. (475 aa) |
| | arx-2 | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (395 aa) |
| | tbce-1 | CAP-Gly domain-containing protein. (493 aa) |
| | dbn-1 | Drebrin-like protein. (643 aa) |
| | aipl-1 | WD_REPEATS_REGION domain-containing protein. (600 aa) |
| | K09E2.2 | Uncharacterized protein. (596 aa) |
| | spc-1 | SPeCtrin. (2432 aa) |
| | unc-70 | Spectrin beta chain; Belongs to the spectrin family. (2326 aa) |
| | klp-7 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (747 aa) |
| | myo-3 | Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa) |
| | vab-8 | Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly. [Isoform b]: Specifically required for CAN cell migration. (1066 aa) |
| | tom-1 | LLGL domain-containing protein. (1255 aa) |
| | clip-1 | CAP-Gly domain-containing linker protein 1 homolog. (937 aa) |
| | arx-7 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa) |
| | klp-15 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (587 aa) |
| | osm-3 | Osmotic avoidance abnormal protein 3; Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport. (699 aa) |
| | zen-4 | Kinesin-like protein. (787 aa) |
| | M04F3.5 | IMD domain-containing protein. (655 aa) |
| | cap-2 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa) |
| | M116.5 | Uncharacterized protein. (1020 aa) |
| | M151.2 | Uncharacterized protein. (582 aa) |
| | klc-1 | TPR_REGION domain-containing protein. (536 aa) |
| | cor-1 | Coronin-like protein cor-1; Required to direct the migration of Q neuroblasts along the anterior axis of the body during larval development. This is dependent on its asymmetric expression in Q neuroblasts. Belongs to the WD repeat coronin family. (607 aa) |
| | R02F11.4 | Uncharacterized protein. (630 aa) |
| | unc-116 | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. (815 aa) |
| | wve-1 | WH2 domain-containing protein. (468 aa) |
| | myo-1 | Myosin-1; Muscle contraction. (1938 aa) |
| | cls-2 | Protein CLASP-2; Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming. Essential for embryonic development. (1023 aa) |
| | spe-26 | Spermatocyte protein spe-26; May play a role in the spermatocyte cytoskeleton, possibly interacting with actin. (570 aa) |
| | nud-2 | Protein nud-2; Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord ; Belongs to the nudE family. (293 aa) |
| | unc-9 | Innexin unc-9; Structural component of the gap junctions. Belongs to the pannexin family. (386 aa) |
| | hmp-1 | Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family. (930 aa) |
| | rmd-6 | Regulator of Microtubule Dynamics. (225 aa) |
| | klp-6 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (928 aa) |
| | wip-1 | WH2 domain-containing protein. (362 aa) |
| | sma-1 | SMAll. (4166 aa) |
| | klp-12 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1605 aa) |
| | mei-1 | Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. In body wall muscles, regulates organization of myosin thick filaments. (475 aa) |
| | hum-5 | Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1017 aa) |
| | lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...] (404 aa) |
| | tag-243 | Costars domain-containing protein. (240 aa) |
| | frm-2 | FERM domain-containing protein. (589 aa) |
| | rmd-1 | Regulator of microtubule dynamics protein 1; Acts in chromosome segregation and organization during mitosis; Belongs to the FAM82/RMD family. (226 aa) |
| | pfd-3 | Probable prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit alpha family. (185 aa) |
| | tnt-4 | TropoNin T. (375 aa) |
| | T08D2.8 | TOG domain-containing protein. (388 aa) |
| | T08G11.3 | Uncharacterized protein. (580 aa) |
| | klp-3 | Kinesin-like protein klp-3. (598 aa) |
| | T10B10.3 | Uncharacterized protein. (741 aa) |
| | hum-6 | Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (2098 aa) |
| | alp-1 | ALP/Enigma encoding. (1424 aa) |
| | drp-1 | Dynamin-Related Protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa) |
| | myo-2 | Myosin-2; Muscle contraction. (1947 aa) |
| | T19C3.4 | Uncharacterized protein T19C3.4. (229 aa) |
| | tni-3 | Troponin I 3; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (260 aa) |
| | pat-6 | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa) |
| | mup-2 | Troponin T; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (405 aa) |
| | T24B8.4 | Uncharacterized protein. (850 aa) |
| | samp-1 | Transmembrane protein 201 homolog; Plays a role in nuclear migration in hypodermal cells. Belongs to the TMEM201 family. (588 aa) |
| | trak-1 | HAP1 N-terminal domain-containing protein. (607 aa) |
| | ebp-2 | Microtubule End Binding Protein. (299 aa) |
| | klp-17 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (471 aa) |
| | W02H5.2 | Uncharacterized protein. (620 aa) |
| | tni-4 | Troponin I 4; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (194 aa) |
| | atn-1 | AcTiniN. (920 aa) |
| | ttn-1 | Titin homolog; Serine/threonine-protein kinase. Key component in the assembly and functioning of muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase (By similarity). (15188 aa) |
| | ipla-3 | Intracelllar PhosphoLipase A family. (1047 aa) |
| | plst-1 | PLaSTin (Actin bundling protein) homolog. (370 aa) |
| | lev-11 | Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa) |
| | ska-1 | Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...] (243 aa) |
| | nmy-3 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1464 aa) |
| | pfn-1 | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. (132 aa) |
| | ctn-1 | Alpha-CaTuliN (Catenin/vinculin related). (820 aa) |
| | spd-1 | SPD-1. (529 aa) |
| | arx-5 | Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (183 aa) |
| | unc-33 | Protein unc-33; During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule- organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Ra [...] (854 aa) |
| | tbca-1 | Tubulin-specific chaperone A; Belongs to the TBCA family. (111 aa) |
| | osm-5 | OSM-5. (820 aa) |
| | klp-19 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1083 aa) |
| | sup-35 | SUPpressor. (332 aa) |
| | ddl-2 | WASH_WAHD domain-containing protein. (497 aa) |
| | frl-1 | FRL (Formin Related gene in Leukocytes) homolog. (1115 aa) |
| | efhc-1 | EF-Hand domain-Containing protein 1 homolog. (447 aa) |
| | ani-1 | Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa) |
| | Y50D7A.10 | ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. GMF subfamily. (138 aa) |
| | klp-20 | Kinesin-like protein klp-20; Component of the kinesin II motor complex (composed of kap-1 and the heterodimeric motor proteins klp-11 and klp-20) which is required for intraflagellar transport (IFT). Heterodimerizes with klp-11 to form a 'processive' molecular motor upon IFT cargo binding, which, within the kinesin II motor complex, binds to and moves along microtubules in a unidirectional manner (without dissociation of the heterodimer), and in turn, is responsible for the IFT of cargo. Specifically, the kinesin II motor complex, together with the kinesin motor protein osm-3 moves alo [...] (646 aa) |
| | grdn-1 | Girdin homolog; Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI and the phasmid neurons PHA and PHB. Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10. Belongs to the CCDC88 family. (1319 aa) |
| | Y55F3C.17 | Uncharacterized protein. (3318 aa) |
| | tag-273 | LIM zinc-binding domain-containing protein. (891 aa) |
| | eps-8 | SH3 domain-containing protein. (942 aa) |
| | tcc-1 | Transmembrane and Coiled-Coil protein. (676 aa) |
| | ebp-1 | Microtubule End Binding Protein. (316 aa) |
| | ebp-3 | EB1 C-terminal domain-containing protein. (187 aa) |
| | Y65B4A.4 | Uncharacterized protein. (124 aa) |
| | hum-8 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1279 aa) |
| | fln-1 | Calponin-homology (CH) domain-containing protein. (2259 aa) |
| | arx-4 | Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (301 aa) |
| | arx-1 | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (425 aa) |
| | tln-1 | Talin. (2553 aa) |
| | Y73B3B.1 | Calponin-homology (CH) domain-containing protein. (376 aa) |
| | Y73B6BL.289 | Uncharacterized protein. (71 aa) |
| | blos-2 | Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the BLOC1S2 family. (132 aa) |
| | pod-1 | Uncharacterized protein. (1136 aa) |
| | zyg-8 | Serine/threonine-protein kinase zyg-8; Plays a role in spindle positioning during asymmetric division of one-cell stage embryos. Affects spindle position by promoting microtubule assembly during anaphase. (802 aa) |
| | arx-3 | Actin-related protein 2/3 complex subunit. (375 aa) |
| | deb-1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa) |
| | cls-3 | Protein CLASP-3; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family. (983 aa) |
| | frg-1 | Protein FRG1 homolog; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B (By similarity); Belongs to the FRG1 family. (274 aa) |
| | unc-16 | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] (1190 aa) |
| | ttll-4 | Tubulin polyglutamylase ttll-4; Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating. (601 aa) |
| | vab-10 | GAR domain-containing protein. (5059 aa) |
| | ZK1321.4 | PDZ domain-containing protein. (429 aa) |
| | frm-1 | FERM domain-containing protein. (4648 aa) |
| | hipr-1 | Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family. (927 aa) |
| | zyg-12 | Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family. (777 aa) |
| | dnc-1 | CAP-Gly domain-containing protein. (1351 aa) |
| | lgg-2 | Protein lgg-2; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion. Less effective at promoting membrane fusion than lgg-1. Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular binds to [...] (142 aa) |
| | ZK632.5 | Uncharacterized protein ZK632.5. (824 aa) |
| | tnc-2 | Troponin C, isoform 2; Belongs to the troponin C family. (160 aa) |
| | unc-27 | Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. (242 aa) |
| | anc-1 | Nuclear anchorage protein 1; Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron. Belongs to the nesprin family. (8545 aa) |
