node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arr-1 | eat-16 | F53H8.2.1 | C16C2.2a.2 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Uncharacterized protein. | 0.459 |
arr-1 | egl-10 | F53H8.2.1 | F28C1.2b.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | 0.498 |
arr-1 | gpb-2 | F53H8.2.1 | F52A8.2a.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.654 |
arr-1 | pde-4 | F53H8.2.1 | R153.1d.1 | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. | 0.612 |
eat-16 | arr-1 | C16C2.2a.2 | F53H8.2.1 | Uncharacterized protein. | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | 0.459 |
eat-16 | egl-10 | C16C2.2a.2 | F28C1.2b.1 | Uncharacterized protein. | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | 0.541 |
eat-16 | gpb-2 | C16C2.2a.2 | F52A8.2a.1 | Uncharacterized protein. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.992 |
egl-10 | arr-1 | F28C1.2b.1 | F53H8.2.1 | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | 0.498 |
egl-10 | eat-16 | F28C1.2b.1 | C16C2.2a.2 | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | Uncharacterized protein. | 0.541 |
egl-10 | gpb-2 | F28C1.2b.1 | F52A8.2a.1 | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.992 |
egl-10 | irk-1 | F28C1.2b.1 | R03E9.4.1 | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. | 0.437 |
gpb-2 | arr-1 | F52A8.2a.1 | F53H8.2.1 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | 0.654 |
gpb-2 | eat-16 | F52A8.2a.1 | C16C2.2a.2 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Uncharacterized protein. | 0.992 |
gpb-2 | egl-10 | F52A8.2a.1 | F28C1.2b.1 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | 0.992 |
gpb-2 | irk-1 | F52A8.2a.1 | R03E9.4.1 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. | 0.618 |
irk-1 | egl-10 | R03E9.4.1 | F28C1.2b.1 | Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. | Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. | 0.437 |
irk-1 | gpb-2 | R03E9.4.1 | F52A8.2a.1 | Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.618 |
pde-4 | arr-1 | R153.1d.1 | F53H8.2.1 | Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP. | Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying. | 0.612 |