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gcy-9 gcy-9 gcy-14 gcy-14 acy-2 acy-2 gcy-32 gcy-32 gcy-27 gcy-27 gcy-15 gcy-15 gcy-25 gcy-25 gcy-17 gcy-17 gcy-23 gcy-23 gcy-31 gcy-31 gcy-35 gcy-35 gcy-22 gcy-22 daf-11 daf-11 gcy-6 gcy-6 gcy-1 gcy-1 acy-4 acy-4 gcy-29 gcy-29 gcy-2 gcy-2 gcy-3 gcy-3 odr-1 odr-1 gcy-34 gcy-34 gcy-33 gcy-33 gcy-7 gcy-7 gcy-13 gcy-13 gcy-21 gcy-21 gcy-20 gcy-20 acy-1 acy-1 gcy-12 gcy-12 gcy-37 gcy-37 gcy-8 gcy-8 gcy-36 gcy-36 acy-3 acy-3 gcy-11 gcy-11 gcy-19 gcy-19 gcy-28 gcy-28 gcy-5 gcy-5 gcy-4 gcy-4 gcy-18 gcy-18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gcy-9Receptor-type guanylate cyclase gcy-9; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of CO2 levels and acidity by the BAG neurons. May act as a direct receptor for CO2 and H+. (1081 aa)
gcy-14Receptor-type guanylate cyclase gcy-14; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4. (1111 aa)
acy-2Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
gcy-32Soluble guanylate cyclase gcy-32; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). Influences aerotaxis responses, aggregation and bordering behaviors (gathering around the edge of a bacterial lawn) in combination with other soluble guanylate cyclases. (684 aa)
gcy-27Receptor-type guanylate cyclase gcy-27; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Promotes the calcium flux to the cytoplasm in ASJ sensory neurons upon removal of a nitric oxide (NO) stimulus and is thereby involved in the behavioral avoidance response to NO-producing organisms like P.aeruginosa. (616 aa)
gcy-15Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1115 aa)
gcy-25Receptor-type guanylate cyclase gcy-25; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1034 aa)
gcy-17Receptor-type guanylate cyclase gcy-17; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1088 aa)
gcy-23Receptor-type guanylate cyclase gcy-23; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. (1073 aa)
gcy-31Soluble guanylate cyclase gcy-31; Synthesizes cyclic GMP (cGMP) from GTP. May play a role in embryogenesis. (702 aa)
gcy-35Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...] (688 aa)
gcy-22Receptor-type guanylate cyclase gcy-22; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron. May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations. (1058 aa)
daf-11Receptor-type guanylate cyclase daf-11; Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response [...] (1077 aa)
gcy-6Receptor-type guanylate cyclase gcy-6; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron. (1086 aa)
gcy-1Receptor-type guanylate cyclase gcy-1; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of K+ gradient by the ASE right (ASER) sensory neuron. (1137 aa)
acy-4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
gcy-29Receptor-type guanylate cyclase gcy-29; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1034 aa)
gcy-2Receptor-type guanylate cyclase gcy-2; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1118 aa)
gcy-3Receptor-type guanylate cyclase gcy-3; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1140 aa)
odr-1Receptor-type guanylate cyclase gcy-10; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons. May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1. Required to maintain the expression of putative olfactory receptor str-2 in AWC neurons in adults. In AWB and AWC sensory neurons, media [...] (1067 aa)
gcy-34Soluble guanylate cyclase gcy-34; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (686 aa)
gcy-33Soluble guanylate cyclase gcy-33; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (947 aa)
gcy-7Receptor-type guanylate cyclase gcy-7; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses toward salt ions in ASEL (ASE left) sensory neurons. (1111 aa)
gcy-13Receptor-type guanylate cyclase gcy-13; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1028 aa)
gcy-21Receptor-type guanylate cyclase gcy-21; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1119 aa)
gcy-20Receptor-type guanylate cyclase gcy-20; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1108 aa)
acy-1Adenylyl CYclase. (1253 aa)
gcy-12Receptor-type guanylate cyclase gcy-12; Guanylate cyclase involved in the production of the second messenger cGMP. Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size. (1679 aa)
gcy-37Soluble guanylate cyclase gcy-37; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (708 aa)
gcy-8Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1. (1152 aa)
gcy-36Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...] (675 aa)
acy-3Adenylyl CYclase. (1243 aa)
gcy-11Receptor-type guanylate cyclase gcy-11; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1205 aa)
gcy-19Receptor-type guanylate cyclase gcy-19; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). (1187 aa)
gcy-28Receptor-type guanylate cyclase gcy-28; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps. [Isoform d]: Regulates sensory integration of conflicting sensory cues in AIA interneurons. (1276 aa)
gcy-5Receptor-type guanylate cyclase gcy-5; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses to salt ions mediated by ASE sensory neurons. (1122 aa)
gcy-4Receptor-type guanylate cyclase gcy-4; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Br(1-) and I(1-) salt ions in ASE right (ASER) sensory neuron. (1136 aa)
gcy-18Receptor-type guanylate cyclase gcy-18; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. (1113 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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