STRINGSTRING
rab-8 rab-8 rab-3 rab-3 C34D4.4 C34D4.4 ehbp-1 ehbp-1 rab-5 rab-5 sec-12 sec-12 K02E10.1 K02E10.1 dab-1 dab-1 mig-14 mig-14 R186.1 R186.1 mom-1 mom-1 T14G10.5 T14G10.5 ekl-6 ekl-6 rab-10 rab-10 apt-9 apt-9 apg-1 apg-1 tfg-1 tfg-1 Y80D3A.9 Y80D3A.9 trpp-3 trpp-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rab-8RAB family. (211 aa)
rab-3Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa)
C34D4.4Uncharacterized Golgi apparatus membrane protein-like protein C34D4.4. (205 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
rab-5RAB family. (208 aa)
sec-12WD_REPEATS_REGION domain-containing protein. (425 aa)
K02E10.1Uncharacterized protein. (218 aa)
dab-1PID domain-containing protein. (492 aa)
mig-14Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...] (549 aa)
R186.1Uncharacterized protein. (276 aa)
mom-1Protein-serine O-palmitoleoyltransferase porcupine; Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins (By similarity). Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle [...] (442 aa)
T14G10.5Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (885 aa)
ekl-6Uncharacterized protein. (964 aa)
rab-10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa)
apt-9AdaPTin or adaptin-related protein. (588 aa)
apg-1AP-1 complex subunit gamma. (829 aa)
tfg-1PB1 domain-containing protein. (486 aa)
Y80D3A.9Uncharacterized protein. (279 aa)
trpp-3Trafficking protein particle complex subunit 3 homolog; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Required for the systemic spread of the RNAi response ; Belongs to the TRAPP small subunits family. BET3 subfamily. (181 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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