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kgb-1 kgb-1 gcy-22 gcy-22 snt-5 snt-5 mtl-1 mtl-1 smf-1 smf-1 smf-2 smf-2 prdx-2 prdx-2 vhp-1 vhp-1 sue-1 sue-1 sur-7 sur-7 DH11.5 DH11.5 che-1 che-1 cdr-3 cdr-3 cdr-2 cdr-2 cnnm-1 cnnm-1 fshr-1 fshr-1 hcf-1 hcf-1 mig-2 mig-2 cnnm-3 cnnm-3 cdf-1 cdf-1 snt-6 snt-6 atf-7 atf-7 clp-1 clp-1 pgp-5 pgp-5 cpna-3 cpna-3 cpna-5 cpna-5 age-1 age-1 pmk-1 pmk-1 gcy-6 gcy-6 gcy-1 gcy-1 mlk-1 mlk-1 pgp-1 pgp-1 T27E4.1 T27E4.1 snt-4 snt-4 natc-1 natc-1 pgp-7 pgp-7 cdf-2 cdf-2 gem-4 gem-4 pgp-3 pgp-3 hizr-1 hizr-1 cutc-1 cutc-1 pmr-1 pmr-1 gcy-14 gcy-14 snt-3 snt-3 cpna-4 cpna-4 smf-3 smf-3 ttm-1 ttm-1 max-2 max-2 lys-3 lys-3 hmt-1 hmt-1 mek-1 mek-1 cdr-4 cdr-4 pdk-1 pdk-1 mrp-1 mrp-1 pcs-1 pcs-1 shc-1 shc-1 F53A9.7 F53A9.7 F53A9.6 F53A9.6 kreg-1 kreg-1 F53A9.1 F53A9.1 gcy-7 gcy-7 haly-1 haly-1 cla-1 cla-1 snt-2 snt-2 pgp-4 pgp-4 F35G12.7 F35G12.7 cdr-1 cdr-1 snt-1 snt-1 F22H10.2 F22H10.2 nra-1 nra-1 snt-7 snt-7 mtl-2 mtl-2 uba-5 uba-5
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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gene fusions
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kgb-1GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa)
gcy-22Receptor-type guanylate cyclase gcy-22; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron. May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations. (1058 aa)
snt-5SyNapTotagmin. (458 aa)
mtl-1Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
smf-1NRAMP-like transporter smf-1; Probable divalent metal ion transporter which regulates Mn(2+) uptake; Belongs to the NRAMP family. (562 aa)
smf-2NRAMP-like transporter smf-2; Probable divalent metal ion transporter which regulates Mn(2+) uptake. (546 aa)
prdx-2Thioredoxin domain-containing protein. (201 aa)
vhp-1Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (661 aa)
sue-1SUppressor of Elongation defect. (537 aa)
sur-7SUppressor of activated let-60 Ras. (371 aa)
DH11.5C2 domain-containing protein. (825 aa)
che-1Transcription factor che-1; Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36. (273 aa)
cdr-3CaDmium Responsive. (278 aa)
cdr-2Cadmium-inducible lysosomal protein CDR-2. (278 aa)
cnnm-1Metal transporter cnnm-1; Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-2, cnnm-3, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling. Belongs to the ACDP family. (811 aa)
fshr-1G_PROTEIN_RECEP_F1_2 domain-containing protein. (932 aa)
hcf-1Host cell factor 1. (782 aa)
mig-2Rac-like GTPase. (195 aa)
cnnm-3Metal transporter cnnm-3; Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling. (797 aa)
cdf-1Cation diffusion facilitator family protein 1; Involved in the regulation of Pn.p cell fate determination. Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling. Involved in zinc transport from the intestinal lumen to the pseudocoelum. (561 aa)
snt-6C2 domain-containing protein. (373 aa)
atf-7BZIP domain-containing protein. (509 aa)
clp-1Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death. (780 aa)
pgp-5p-GlycoProtein related. (1252 aa)
cpna-3VWFA domain-containing protein. (520 aa)
cpna-5Copine family protein 5. (717 aa)
age-1Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1182 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
gcy-6Receptor-type guanylate cyclase gcy-6; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron. (1086 aa)
gcy-1Receptor-type guanylate cyclase gcy-1; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of K+ gradient by the ASE right (ASER) sensory neuron. (1137 aa)
mlk-1Mitogen-activated protein kinase kinase kinase mlk-1; Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Involved in the response to environmental stress such as heavy metals. By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury. (1059 aa)
pgp-1Multidrug resistance protein pgp-1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1321 aa)
T27E4.1Uncharacterized protein. (309 aa)
snt-4SyNapTotagmin. (381 aa)
natc-1N-alpha-AcetylTransferase C complex subunit. (799 aa)
pgp-7p-GlycoProtein related. (1263 aa)
cdf-2Cation Diffusion Facilitator family. (360 aa)
gem-4Gon-2 Extragenic Modifier. (625 aa)
pgp-3Multidrug resistance protein pgp-3; Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm. Hydrolyzes ATP with low efficiency (By similarity); Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1268 aa)
hizr-1High zinc activated nuclear receptor protein; Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated. (413 aa)
cutc-1Copper homeostasis protein cutC homolog; Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size; Belongs to the CutC family. (250 aa)
pmr-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (978 aa)
gcy-14Receptor-type guanylate cyclase gcy-14; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4. (1111 aa)
snt-3SyNapTotagmin. (284 aa)
cpna-4Copine domain-containing protein. (610 aa)
smf-3NRAMP-like transporter smf-3; Probable divalent metal ion transporter which regulates the uptake of several heavy metals such as Mn(2+), Al(3+) and iron. Plays a role in modulating Al(3+)-induced dopamine (DA) neuron degeneration through the intracellular sequestration of Al(3+). (560 aa)
ttm-1Zinc transporter ttm-1; Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc. Involved in cadmium resistance, possibly by promoting its transport from cells. Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway. (410 aa)
max-2Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa)
lys-3Lysozyme-like protein 3; Plays a role in the stress response to heavy metals such as copper, probably in a kgb-1-dependent manner. (301 aa)
hmt-1Heavy metal tolerance factor 1. (801 aa)
mek-1Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] (347 aa)
cdr-4Cadmium-inducible lysosomal protein CDR-4. (277 aa)
pdk-13-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (636 aa)
mrp-1Uncharacterized protein. (1534 aa)
pcs-1Peptidase C83 domain-containing protein. (426 aa)
shc-1SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...] (316 aa)
F53A9.7Uncharacterized protein. (85 aa)
F53A9.6Uncharacterized protein. (86 aa)
kreg-1Protein kreg-1; Plays a role in the stress response to heavy metals such as copper, probably in a fos-1/kgb-1-dependent manner. (83 aa)
F53A9.1Uncharacterized protein. (77 aa)
gcy-7Receptor-type guanylate cyclase gcy-7; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses toward salt ions in ASEL (ASE left) sensory neurons. (1111 aa)
haly-1Histidine ammonia-lyase; Belongs to the PAL/histidase family. (677 aa)
cla-1Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...] (8922 aa)
snt-2Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa)
pgp-4p-GlycoProtein related. (1280 aa)
F35G12.7Uncharacterized protein. (115 aa)
cdr-1Cadmium-inducible lysosomal protein CDR-1. (277 aa)
snt-1Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa)
F22H10.2Uncharacterized protein. (102 aa)
nra-1Nicotinic receptor-associated protein 1; Exhibits calcium-dependent phospholipid binding properties (By similarity). May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole. Affects directional sperm motility. (634 aa)
snt-7C2 domain-containing protein. (416 aa)
mtl-2Metallothionein-2; This protein binds cations of several transition elements. (63 aa)
uba-5Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1; Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. (419 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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