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| | vps-34 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa) |
| | lgg-3 | Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...] (118 aa) |
| | vps-51 | Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS51 family. (700 aa) |
| | B0511.12 | Pecanex_C domain-containing protein. (2245 aa) |
| | scrm-3 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (251 aa) |
| | lnp-1 | Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1; Belongs to the lunapark family. (346 aa) |
| | C06E1.1 | Uncharacterized protein C06E1.1. (161 aa) |
| | cogc-2 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function. (681 aa) |
| | C06G3.6 | ZZ-type domain-containing protein. (498 aa) |
| | oma-1 | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] (407 aa) |
| | ccm-3 | Programmed cell death protein 10 homolog; Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility. (215 aa) |
| | plk-1 | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] (649 aa) |
| | syx-6 | Putative syntaxin 6; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (122 aa) |
| | maa-1 | ACB domain-containing protein. (266 aa) |
| | tram-1 | Translocating chain-associated membrane protein; Belongs to the TRAM family. (373 aa) |
| | gbf-1 | SEC7 domain-containing protein. (1975 aa) |
| | C26C6.9 | GOLD domain-containing protein. (217 aa) |
| | lgg-1 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] (123 aa) |
| | ric-19 | Resistance to inhibitors of cholinesterase protein 19; May be involved in a role in neurotransmitter secretion. (430 aa) |
| | tbc-8 | Rab-GAP TBC domain-containing protein. (913 aa) |
| | acn-1 | Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] (906 aa) |
| | ifp-1 | Intermediate filament protein ifp-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (776 aa) |
| | C47D12.2 | Uncharacterized protein. (689 aa) |
| | sft-4 | Surfeit locus protein 4 homolog; Belongs to the SURF4 family. (277 aa) |
| | cav-2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family. (351 aa) |
| | C56A3.8 | PI3K/PI4K domain-containing protein. (402 aa) |
| | lmn-1 | Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa) |
| | ced-8 | Cell death abnormality protein 8; Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses. Belongs to the XK family. (458 aa) |
| | ifb-1 | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. (589 aa) |
| | ifb-2 | Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. (577 aa) |
| | F10C1.8 | LTD domain-containing protein. (160 aa) |
| | farl-11 | DUF3402 domain-containing protein. (978 aa) |
| | scrm-4 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (260 aa) |
| | F13B9.1 | Protein transport protein sec16. (1632 aa) |
| | rme-8 | J domain-containing protein. (2279 aa) |
| | ifd-2 | Intermediate filament protein ifd-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (443 aa) |
| | ima-2 | Importin subunit alpha-2; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). (531 aa) |
| | cee-1 | Conserved Edge Expressed protein. (362 aa) |
| | F32D8.14 | Protein YIPF. (261 aa) |
| | vpr-1 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (245 aa) |
| | golg-2 | GOLGi associated coiled-coil protein homolog. (928 aa) |
| | syx-3 | Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). (306 aa) |
| | ifc-1 | Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (500 aa) |
| | ifa-1 | Intermediate filament protein ifa-1; Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis. (592 aa) |
| | let-92 | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] (318 aa) |
| | atg-18 | Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...] (412 aa) |
| | F41H10.5 | TLC domain-containing protein. (277 aa) |
| | F42G2.5 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (374 aa) |
| | fer-1 | Sperm vesicle fusion protein fer-1; Required for the fusion of the membranous organelles (MOs) with the plasma membrane, a process essential in spermiogenesis. (2034 aa) |
| | sdpn-1 | SynDaPiN (Synaptic dynamin binding protein) homolog. (495 aa) |
| | cnep-1 | CTD nuclear envelope phosphatase 1 homolog; Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. (276 aa) |
| | scrm-6 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. (292 aa) |
| | F47G9.1 | GOLD domain-containing protein. (204 aa) |
| | syx-2 | Putative syntaxin-2; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (299 aa) |
| | ifa-3 | Intermediate filament protein ifa-3; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures. (581 aa) |
| | unc-108 | Uncharacterized protein. (223 aa) |
| | unc-84 | Nuclear migration and anchoring protein unc-84; Involved in nuclear migration and anchoring in hypodermal precursor cells. Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Its role in nuclear migration may be in association with lamin, lmn-1. Regulates nuclear mi [...] (1111 aa) |
| | F54H5.3 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (279 aa) |
| | sec-22 | Yeast SEC homolog; Belongs to the synaptobrevin family. (214 aa) |
| | unc-64 | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa) |
| | sun-1 | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. (473 aa) |
| | F57B10.5 | GOLD domain-containing protein. (203 aa) |
| | F58E6.5 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (304 aa) |
| | tat-2 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1349 aa) |
| | lpin-1 | LNS2 domain-containing protein. (794 aa) |
| | unc-26 | Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa) |
| | snap-29 | Soluble NSF attachment protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion; Belongs to the SNAP-25 family. (277 aa) |
| | cdk-2 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase which, in association with cye-1, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. . In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. Phosphorylation and inhibition of the translational repressor gld-1 by the cdk-2/cye-1 complex regulates the pool of germline stem cells and the size of the mitotic zone in the gonads by preventing entry into meiosis. (338 aa) |
| | ifa-4 | Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein. (575 aa) |
| | K05C4.2 | Protein jagunal homolog. (189 aa) |
| | ile-1 | L-type lectin-like domain-containing protein. (492 aa) |
| | scrm-8 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. (301 aa) |
| | scrm-5 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. (303 aa) |
| | K08E4.6 | GOLD domain-containing protein. (234 aa) |
| | uso-1 | USO1 (Yeast transport protein) homolog. (941 aa) |
| | K10B2.4 | Protein Asterix. (113 aa) |
| | K11H3.4 | Uncharacterized protein K11H3.4. (364 aa) |
| | K12H6.6 | TLC domain-containing protein. (309 aa) |
| | ostd-1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (280 aa) |
| | emr-1 | Emerin homolog 1; Involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with lem-2. May play a role in radiation- induced DNA damage repair response. (166 aa) |
| | M02B1.3 | TLC domain-containing protein. (322 aa) |
| | M04F3.5 | IMD domain-containing protein. (655 aa) |
| | ifc-2 | Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion. (1248 aa) |
| | ifd-1 | Intermediate filament protein ifd-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (575 aa) |
| | R05H5.5 | ARV1 homolog. (236 aa) |
| | vps-11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] (980 aa) |
| | alx-1 | Apoptosis-linked gene 2-interacting protein X 1; Required for lin-12 degradation after it has been internalised in the vulval precursor cells. (882 aa) |
| | R12B2.2 | Uncharacterized protein. (281 aa) |
| | R186.1 | Uncharacterized protein. (276 aa) |
| | syx-4 | Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones. (296 aa) |
| | sec-31 | WD_REPEATS_REGION domain-containing protein. (1083 aa) |
| | T02E1.7 | Uncharacterized protein T02E1.7; Belongs to the SURF4 family. (269 aa) |
| | ile-2 | L-type lectin-like domain-containing protein. (347 aa) |
| | T05E7.3 | Uncharacterized protein. (997 aa) |
| | T08D2.1 | GOLD domain-containing protein. (167 aa) |
| | T10B10.3 | Uncharacterized protein. (741 aa) |
| | sqst-1 | SeQueSTosome related. (693 aa) |
| | cav-1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa) |
| | aex-4 | t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family. (234 aa) |
| | sqst-5 | Protein ver-2; May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail. (192 aa) |
| | T19C3.4 | Uncharacterized protein T19C3.4. (229 aa) |
| | rund-1 | RUN domain-containing protein. (549 aa) |
| | scrm-1 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. (295 aa) |
| | T24B1.1 | Golgin-84; May be involved in maintaining Golgi structure and in intra- Golgi transport. (551 aa) |
| | sqst-3 | ZZ-type domain-containing protein. (229 aa) |
| | lem-2 | LEM protein 2; Essential protein involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with emr-1. May play a role in radiation-induced DNA damage repair response. (500 aa) |
| | sel-9 | Suppressor/enhancer of lin-12 protein 9; May have a role in the negative regulation of lin-12 and glp- 1 transport to the cell surface. May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles. Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction. Belongs to the EMP24/GP25L family. (203 aa) |
| | vps-18 | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa) |
| | W08E3.4 | Uncharacterized protein. (267 aa) |
| | apd-3 | AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa) |
| | mua-6 | Intermediate filament protein ifa-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle- cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos. (581 aa) |
| | hut-1 | Yeast Homolog UDP-Gal Transporter. (340 aa) |
| | sql-1 | Suppressor of gpa-3QL dye-filling defect. (1328 aa) |
| | ric-4 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. (234 aa) |
| | sqst-4 | ZZ-type domain-containing protein. (177 aa) |
| | lst-4 | Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family. (592 aa) |
| | unc-71 | Disintegrin and metalloproteinase domain-containing protein unc-71; Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development. Involved in axon branching and guidance of neurons including GABAergic type D motor neurons. Promotes sex myoblast migration and positioning independently of gonad attraction cues. May act downstream of mig-13 in order to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis. Required for coordinated movements. (1042 aa) |
| | npp-25 | Transmembrane protein 33 homolog. (271 aa) |
| | epg-3 | Ectopic P granules protein 3; Involved in autophagy. Thought to act in autophagasome and omegasome formation. (458 aa) |
| | Y37D8A.25 | PH domain-containing protein. (141 aa) |
| | Y38F2AR.10 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (184 aa) |
| | sqst-2 | ZZ-type domain-containing protein. (242 aa) |
| | atln-2 | GB1/RHD3-type G domain-containing protein. (520 aa) |
| | Y42H9AR.1 | GRASP55_65 domain-containing protein. (506 aa) |
| | Y47G6A.18 | Uncharacterized protein. (280 aa) |
| | Y48G8AL.13 | TLC domain-containing protein. (278 aa) |
| | cccp-1 | CARD domain-containing protein. (743 aa) |
| | wrb-1 | WRB (Human W(Tryptophan)-Rich Basic nuclear protein) homolog. (196 aa) |
| | scrm-7 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (293 aa) |
| | cogc-4 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function; Belongs to the COG4 family. (801 aa) |
| | wee-1.3 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (677 aa) |
| | Y53F4B.21 | Uncharacterized protein. (1145 aa) |
| | ral-1 | RAL (Ras-related GTPase) homolog. (254 aa) |
| | atln-1 | GB1/RHD3-type G domain-containing protein. (573 aa) |
| | efa-6 | Exchange factor for Arf-6; Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells. (818 aa) |
| | rbm-39 | RNA Binding Motif protein homolog. (580 aa) |
| | lem-4 | Ankyrin repeat and LEM domain-containing protein 2 homolog; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit. Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. (603 aa) |
| | vti-1 | t-SNARE coiled-coil homology domain-containing protein. (224 aa) |
| | nbet-1 | t-SNARE coiled-coil homology domain-containing protein. (107 aa) |
| | Y60A3A.19 | Protein YIPF. (255 aa) |
| | Y60A3A.9 | GOLD domain-containing protein. (211 aa) |
| | Y63D3A.8 | TLC domain-containing protein fld-1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. (350 aa) |
| | Y66D12A.8 | Uncharacterized protein. (244 aa) |
| | cogc-3 | Conserved Oligomeric Golgi (COG) Component. (794 aa) |
| | Y73B6BL.36 | GOLD domain-containing protein. (222 aa) |
| | Y80D3A.9 | Uncharacterized protein. (279 aa) |
| | ubxn-2 | UBX domain-containing protein 2; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling [...] (301 aa) |
| | ZC196.2 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (345 aa) |
| | oma-2 | CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa) |
| | ZC8.6 | PI3K/PI4K domain-containing protein. (593 aa) |
| | scrm-2 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (265 aa) |
| | sec-16 | Protein transport protein Sec16. (1232 aa) |
| | lgg-2 | Protein lgg-2; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion. Less effective at promoting membrane fusion than lgg-1. Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular binds to [...] (142 aa) |
| | ZK632.12 | Uncharacterized protein ZK632.12. (266 aa) |
| | asna-1 | ATPase asna-1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (342 aa) |
