Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Autophagy-related protein 2; Component of the epg-6/atg-2 complex, which is involved in the generation of autophagosomes from omegasomes and in the distribution of atg-9 and atg-13 during the autophagy-mediated degradation of protein aggregates. Involved in autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes, which is essential for maintaining nucleotide homeostasis.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Raptor_N domain-containing protein.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

ATG11 domain-containing protein.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Ectopic P Granules.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...]

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...]

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Protein lgg-2; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion. Less effective at promoting membrane fusion than lgg-1. Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular binds to [...]

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

RAs-related GTP-binding protein A.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

RAs-related GTP binding protein C homolog.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2.

Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.

Serine/threonine-protein kinase unc-51; Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell [...]

DEP domain-containing protein.

Nitrogen Permease Regulator Like homolog.

DEP domain-containing protein.

GATOR complex protein NPRL3; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.

DEP domain-containing protein.

RAs-related GTP-binding protein A.

DEP domain-containing protein.

RAs-related GTP binding protein C homolog.

DEP domain-containing protein.

Sestrin homolog; May function as a negative feedback regulator of TOR function.

Allophagy receptor allo-1; Autophagy receptor, which is required for allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in early embryos. After fertilization, recruited to ubiquitin-modified paternal organelles and is required for the formation of autophagosomes around the paternal organelles. Also plays a role in the regulation of autophagy in germ cells.

Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1; Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos. Phosphorylates the allophagy receptor allo-1, which is required for allophagy.