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| | Y23H5A.3 | Uncharacterized protein. (307 aa) |
| | mes-4 | Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to [...] (898 aa) |
| | tor-2 | Torsin. (310 aa) |
| | mrg-1 | MRG domain-containing protein. (337 aa) |
| | smgl-2 | Uncharacterized protein. (1089 aa) |
| | eri-5 | Tudor domain-containing protein. (531 aa) |
| | xrn-1 | 5'-3' exoribonuclease 1. (1591 aa) |
| | dmd-3 | Doublesex- and mab-3-related transcription factor dmd-3; Transcriptional activator which promotes male-specific development. Acts partially redundantly with the transcription factor mab-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. This is most likely through the regulation of downstream effectors such as eff-1. May also negatively regulate the expression of other proteins implicated in male tail morphogenesis including nhr-25, vav-1 and arl-1 in tail tip cells. In males, plays a role in the development of ray A-neurons by negativ [...] (250 aa) |
| | Y43F8C.11 | Uncharacterized protein. (96 aa) |
| | Y44E3A.6 | FHA domain-containing protein. (843 aa) |
| | Y45G5AM.2 | Uncharacterized protein; Belongs to the peptidase M24B family. (1061 aa) |
| | tiar-2 | TIA-1/TIAL RNA binding protein homolog. (434 aa) |
| | ttc-37 | TeTratriCopeptide repeat domain protein related. (1114 aa) |
| | spg-7 | AFG3-like protein spg-7; Acts as a component of the m-AAA protease complex which is an ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins (By similarity). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (By similarity). Functions both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides. Plays a role in male tail tip morphogenesis. In the C-terminal section; belongs to the peptidase M41 family. (782 aa) |
| | rde-10 | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. (627 aa) |
| | Y47H10A.3 | Uncharacterized protein. (333 aa) |
| | Y47H10A.4 | Uncharacterized protein. (327 aa) |
| | Y47H10A.5 | Uncharacterized protein. (331 aa) |
| | csp-3 | Non-catalytic caspase homolog csp-3; Non-catalytic caspase homolog which does not contain the region necessary for caspase activity. Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4- induced ced-3 processing. Has no effect on active ced-3. Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development ; Belongs to the peptidase C14A family. (139 aa) |
| | xrn-2 | 5'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (975 aa) |
| | eat-2 | Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic [...] (474 aa) |
| | sam-10 | Single-stranded DNA-binding protein homolog sam-10; Involved cell autonomously in PLM neuron pre-synaptic differentiation by negatively regulating prk-2 expression and in neurite branch positioning. (455 aa) |
| | Y48G1C.1 | Uncharacterized protein. (454 aa) |
| | haf-6 | HAlF transporter (PGP related). (668 aa) |
| | smg-2 | Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity). (1069 aa) |
| | gcn-1 | TOG domain-containing protein. (2651 aa) |
| | hsf-1 | HSF_DOMAIN domain-containing protein. (671 aa) |
| | fog-1 | RRM domain-containing protein. (619 aa) |
| | rpb-7 | S1 motif domain-containing protein. (197 aa) |
| | smg-9 | Protein smg-9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG9 family. (385 aa) |
| | smg-6 | PINc domain-containing protein. (1241 aa) |
| | ppm-1.D | PPM-type phosphatase domain-containing protein. (766 aa) |
| | lin-22 | BHLH domain-containing protein. (173 aa) |
| | daf-2 | Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa) |
| | dcap-1 | mRNA_decap_C domain-containing protein. (332 aa) |
| | ntl-3 | NOT2_3_5 domain-containing protein. (701 aa) |
| | ccf-1 | CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family. (310 aa) |
| | Y57G11C.9 | RRM domain-containing protein. (625 aa) |
| | deps-1 | Uncharacterized protein. (619 aa) |
| | exos-4.2 | RNase_PH domain-containing protein. (241 aa) |
| | laf-1 | ATP-dependent RNA helicase laf-1; Multifunctional ATP-dependent RNA helicase. Plays a role in RNA remodeling, but is not required for RNA unwinding. Binds to RNA in a concentration-dependent manner to stimulate annealing between two complementary strands of RNA. This process is also dependent upon ATP; ATP reduces binding to RNA and subsequently diminishes RNA annealing. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in the regulation of transcription and translation initiation. Involved in innate immunity (By si [...] (708 aa) |
| | smg-7 | TPR_REGION domain-containing protein. (458 aa) |
| | smg-3 | Suppressor with Morphological effect on Genitalia. (1144 aa) |
| | exos-2 | EXOSome (Multiexonuclease complex) component. (303 aa) |
| | csp-2 | Putative inactive caspase B subunit p17; [Isoform b]: Putative inactive caspase. In the germline, binds caspase ced-3 zymogen and prevents ced-3 autoactivation. Does not affect the caspase activity of mature ced-3 and ced-4-mediated mature ced-3 activation. Negatively regulates germline apoptosis by inhibiting autocleavage of caspase ced-3. Involved in fertility ; Belongs to the peptidase C14A family. (826 aa) |
| | ntl-11 | NOT-Like (Yeast CCR4/NOT complex component). (640 aa) |
| | Y75B8A.31 | FAM172 family protein homolog Y75B8A.31; Belongs to the FAM172 family. (313 aa) |
| | gcn-2 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] (1699 aa) |
| | nyn-2 | RNase_Zc3h12a_2 domain-containing protein. (489 aa) |
| | rpb-9 | TFIIS-type domain-containing protein; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (167 aa) |
| | morc-1 | Protein morc-1; Involved in gene silencing. Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes. May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes. Promotes transgenerational epigenetic inheritance and germline immortality. (845 aa) |
| | ZC190.4 | SAM domain-containing protein. (629 aa) |
| | clk-1 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner; Belongs to the COQ7 family. (187 aa) |
| | rde-8 | RNase_Zc3h12a domain-containing protein. (339 aa) |
| | oma-2 | CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa) |
| | ccr-4 | Endo/exonuclease/phosphatase domain-containing protein. (677 aa) |
| | ZK1067.2 | NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline. (2443 aa) |
| | mut-7 | Exonuclease mut-7; Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers. (910 aa) |
| | ncl-1 | B-box type zinc finger protein ncl-1; Translational repressor that inhibits protein synthesis. Represses the translation of mRNAs such as fib-1, probably by being recruited by RNA-binding protein nos-2 and the Pumilio proteins puf-5, puf-8 and puf-9 to the consensus core PUF binding motif in the 3'-UTR of fib-1 mRNA. Negatively regulates ribosomal RNA (rRNA) synthesis, ribosomal protein synthesis and nucleolus size. Its role in the negative regulation of nucleolus size is most likely through its negative regulation of the translation of proteins such as the rRNA 2'- O-methyltransferase [...] (982 aa) |
| | nos-2 | Nanos-type domain-containing protein; Belongs to the nanos family. (259 aa) |
| | mett-10 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA) (By similarity). Involved in mRNA splicing (By similarity). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo. Belongs to the methyltransferase superfamily. METTL16/RlmF family. (479 aa) |
| | haf-9 | ABC transmembrane type-1 domain-containing protein. (815 aa) |
| | ZK512.4 | Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity). (76 aa) |
| | sid-2 | Systemic RNA interference defective protein 2; Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. (311 aa) |
| | panl-3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (632 aa) |
| | C37H5.14 | RAI1 domain-containing protein. (322 aa) |
| | cpb-1 | Cytoplasmic polyadenylation element-binding protein 1; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis. (560 aa) |
| | C41G7.3 | Messenger RNA-binding inhibitor of apoptosis 1; RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline. Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline. (393 aa) |
| | ifp-1 | Intermediate filament protein ifp-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (776 aa) |
| | C44H9.4 | Uncharacterized protein. (1099 aa) |
| | eif-6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing. (246 aa) |
| | smg-1 | Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2. (2322 aa) |
| | drh-3 | Dicer Related Helicase. (1119 aa) |
| | prg-1 | Piwi-like protein; Belongs to the argonaute family. (824 aa) |
| | atx-2 | Ataxin-2 homolog; Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1. Belongs to the ataxin-2 [...] (1026 aa) |
| | pgp-11 | p-GlycoProtein related. (1270 aa) |
| | lmn-1 | Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa) |
| | E01A2.2 | Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity). (712 aa) |
| | gpa-3 | Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde- 1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behaviora [...] (353 aa) |
| | tofu-6 | Embryonic developmental protein tofu-6; Required maternally for early embryonic cell divisions. May have a role in DNA replication. (367 aa) |
| | ifd-2 | Intermediate filament protein ifd-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (443 aa) |
| | ddx-23 | DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (730 aa) |
| | skih-2 | SKI (Yeast SuperKIller) Helicase homolog. (1266 aa) |
| | lin-28 | Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. (227 aa) |
| | F07H5.10 | RAI1 domain-containing protein. (334 aa) |
| | crn-7 | Cell-death-related nuclease 7; Belongs to the DNase II family. (367 aa) |
| | rrf-3 | RNA-dependent RNA polymerase Family. (1765 aa) |
| | ifb-1 | Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2. (589 aa) |
| | ifb-2 | Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413. (577 aa) |
| | F10C1.8 | LTD domain-containing protein. (160 aa) |
| | F10E7.5 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (220 aa) |
| | tsn-1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (914 aa) |
| | tir-1 | NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification [...] (984 aa) |
| | mrpl-13 | Mitochondrial Ribosomal Protein, Large. (205 aa) |
| | sid-5 | Systemic RNA interference defective protein 5; Plays a role in RNA-mediated gene silencing by mediating transport of both ingested and endogenous dsRNA between cells. Not required for the uptake of dsRNA from the intestinal lumen. (67 aa) |
| | drh-1 | Dicer-related helicase. (1037 aa) |
| | pid-1 | 21U-RNA biogenesis factor pid-1; Plays a role in the biogenesis of 21U-RNAs which guide the piwi protein prg-1 to its DNA targets for silencing. (169 aa) |
| | puf-6 | Pumilio domain-containing protein 6; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa) |
| | csr-1 | Piwi domain-containing protein. (1030 aa) |
| | smgl-1 | Uncharacterized protein. (1615 aa) |
| | rde-2 | Uncharacterized protein. (578 aa) |
| | fbf-2 | Fem-3 mRNA-binding factor 2; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR. Suppresses germline tumor formation by preventing the d [...] (632 aa) |
| | ekl-1 | Uncharacterized protein. (606 aa) |
| | ain-2 | ALG-1 INteracting protein. (748 aa) |
| | let-363 | Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...] (2695 aa) |
| | ntl-2 | NOT2_3_5 domain-containing protein. (444 aa) |
| | sid-3 | Tyrosine-protein kinase sid-3; Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal tissues. (1237 aa) |
| | ife-3 | Eukaryotic translation initiation factor 4E-3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...] (251 aa) |
| | mut-16 | MUTator. (1054 aa) |
| | B0393.4 | Maelstrom domain-containing protein. (803 aa) |
| | daf-7 | Dauer larva development regulatory growth factor daf-7; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. (350 aa) |
| | rnt-1 | Runt domain-containing protein. (301 aa) |
| | cpb-3 | Cytoplasmic polyadenylation element-binding protein 3; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). May not be required for oogenesis. (745 aa) |
| | lin-66 | Uncharacterized protein. (627 aa) |
| | rde-11 | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. (316 aa) |
| | pup-2 | PAP-associated domain-containing protein. (508 aa) |
| | sea-2 | C2H2-type domain-containing protein. (1968 aa) |
| | sca-1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa) |
| | K12H4.2 | Uncharacterized protein K12H4.2; Belongs to the Iojap/RsfS family. (190 aa) |
| | dcr-1 | Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily. (1910 aa) |
| | rpl-16 | 60S ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (202 aa) |
| | rrf-2 | RNA-dependent RNA polymerase Family. (1579 aa) |
| | M01G12.14 | Uncharacterized protein. (350 aa) |
| | M01G12.7 | Uncharacterized protein. (460 aa) |
| | M01G12.9 | Uncharacterized protein. (469 aa) |
| | hat-1 | Hat1_N domain-containing protein. (411 aa) |
| | gfl-1 | GAS41-Like. (211 aa) |
| | rle-1 | Regulation of longevity by E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance. Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection. (952 aa) |
| | ifc-2 | Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion. (1248 aa) |
| | cog-1 | Homeobox domain-containing protein. (256 aa) |
| | nos-1 | Nanos-type domain-containing protein; Belongs to the nanos family. (311 aa) |
| | nrde-3 | Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation. (1057 aa) |
| | ifd-1 | Intermediate filament protein ifd-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (575 aa) |
| | edc-3 | DFDF domain-containing protein. (566 aa) |
| | met-2 | Histone-lysine N-methyltransferase met-2; Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish betwee [...] (1304 aa) |
| | parn-1 | 3'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro. (566 aa) |
| | rde-1 | RNA interference promoting factor RDE-1. (1020 aa) |
| | K07B1.7 | G-patch domain-containing protein. (503 aa) |
| | ifa-4 | Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein. (575 aa) |
| | mut-2 | NTP_transf_2 domain-containing protein. (441 aa) |
| | smg-8 | Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG8 family. (873 aa) |
| | atp-2 | ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (538 aa) |
| | lim-6 | LIM domain family. (316 aa) |
| | hpl-2 | Chromo domain-containing protein. (303 aa) |
| | fbf-1 | Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa) |
| | exos-3 | KH_dom_type_1 domain-containing protein. (226 aa) |
| | rde-12 | DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. (959 aa) |
| | wago-4 | Argonaute protein wago-4; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Also interacts with the mRNA targets of 22G-RNAs. Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes. Belongs to the argonaute family. WAGO subfamily. (965 aa) |
| | ddx-17 | DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (561 aa) |
| | mrp-1 | Uncharacterized protein. (1534 aa) |
| | let-711 | Not1 domain-containing protein. (2641 aa) |
| | ifet-1 | Translational repressor ifet-1; Involved in translational repression of multiple mRNAs in the distal gonad. Recruited to the 3' untranslated region (UTR) of zif-1 by oma-1 and is required for translational repression of zif-1. May also be involved in translational repression of mei-1 through recruitment to the mei-1 3' UTR by oma-1. Required for oogenesis but not spermatogenesis, for P granule formation and for the localization of car-1 and cgh-1 to P granules. Required for normal spindle orientation in early embryos. (761 aa) |
| | nhl-1 | RING finger protein nhl-1. (974 aa) |
| | zfp-1 | Zinc finger protein zfp-1; Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription. Recognizes and binds histone H3 methylated at 'Lys- 4' (H3K4me) at the promoters of target genes. During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated [...] (867 aa) |
| | emb-30 | Abnormal embryogenesis protein 30; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells. Required for embryonic anterior- posterior axis formation. Negatively regulat [...] (1027 aa) |
| | dom-3 | Decapping nuclease dom-3; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). (393 aa) |
| | mex-3 | Muscle EXcess. (443 aa) |
| | dcap-2 | mRNA-decapping enzyme 2; RNA-decapping enzyme although it does not bind cap. May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs. Belongs to the Nudix hydrolase family. DCP2 subfamily. (786 aa) |
| | ifa-3 | Intermediate filament protein ifa-3; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures. (581 aa) |
| | pqe-1 | Putative RNA exonuclease pqe-1; Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins. It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration. Regulates gene expression in neurons. (1647 aa) |
| | gpb-2 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa) |
| | efl-3 | E2F-like (Mammalian transcription factor). (600 aa) |
| | skpo-1 | Peroxidase skpo-1; Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis. Belongs to the peroxidase family. XPO subfamily. (655 aa) |
| | alg-1 | Protein argonaute; Belongs to the argonaute family. (1023 aa) |
| | disl-2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (848 aa) |
| | pek-1 | Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1077 aa) |
| | smg-4 | Smg4_UPF3 domain-containing protein. (368 aa) |
| | exos-4.1 | Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events; Belongs to the RNase PH family. (240 aa) |
| | BE0003N10.1 | S1 motif domain-containing protein. (738 aa) |
| | henn-1 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] (442 aa) |
| | npp-14 | Nuclear pore complex protein 14; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4. (1390 aa) |
| | C04B4.1 | Uncharacterized protein. (491 aa) |
| | C04B4.2 | Uncharacterized protein. (474 aa) |
| | C04B4.4 | Uncharacterized protein. (489 aa) |
| | sid-1 | Systemic RNA interference defective protein 1; Plays a role in RNA-mediated gene silencing by acting cell- autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Belongs to the SID1 family. (776 aa) |
| | C05C10.2 | Uncharacterized ATP-dependent helicase C05C10.2; Belongs to the DNA2/NAM7 helicase family. (1553 aa) |
| | wht-1 | ABC transporter ATP-binding protein/permease wht-1; Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. (671 aa) |
| | mel-32 | Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. (507 aa) |
| | C06A5.6 | Uncharacterized protein. (691 aa) |
| | ain-1 | ALG-1 INteracting protein. (641 aa) |
| | nuc-1 | Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family. (375 aa) |
| | cgh-1 | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (430 aa) |
| | oma-1 | CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] (407 aa) |
| | egal-1 | Egalitarian protein homolog; Part of a complex with bicd-1 and dlc-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. (574 aa) |
| | lin-41 | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa) |
| | crn-3 | HRDC domain-containing protein. (876 aa) |
| | crn-5 | RNase_PH domain-containing protein. (214 aa) |
| | wdr-5.1 | WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...] (376 aa) |
| | nrde-1 | Uncharacterized protein. (793 aa) |
| | mut-14 | MUTator; Belongs to the DEAD box helicase family. (528 aa) |
| | hrde-1 | Uncharacterized protein C16C10.3. (1032 aa) |
| | tiar-1 | RRM domain-containing protein. (408 aa) |
| | abt-1 | ABC transporter domain-containing protein. (1558 aa) |
| | hel-1 | Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly. (425 aa) |
| | ntl-9 | NOT-Like (Yeast CCR4/NOT complex component). (330 aa) |
| | fsn-1 | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] (332 aa) |
| | rad-26 | Uncharacterized protein. (1274 aa) |
| | cpb-2 | Cytoplasmic polyadenylation element-binding protein 2; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis. (570 aa) |
| | mab-23 | Putative transcription factor MAB-23. (175 aa) |
| | C32E8.5 | FHA domain-containing protein. (299 aa) |
| | skr-1 | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa) |
| | skr-2 | SKp1 Related (Ubiquitin ligase complex component). (174 aa) |
| | ned-8 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. (77 aa) |
| | nrde-4 | Uncharacterized protein. (785 aa) |
| | tag-153 | NOT2_3_5 domain-containing protein. (733 aa) |
| | patr-1 | Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family. (833 aa) |
| | haf-2 | HAlF transporter (PGP related). (773 aa) |
| | rpb-4 | RPOL4c domain-containing protein. (144 aa) |
| | isp-1 | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (276 aa) |
| | pgp-4 | p-GlycoProtein related. (1280 aa) |
| | exos-8 | RNase_PH domain-containing protein. (277 aa) |
| | mxl-2 | BHLH domain-containing protein. (205 aa) |
| | lsm-1 | U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (125 aa) |
| | ifa-1 | Intermediate filament protein ifa-1; Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis. (592 aa) |
| | ncbp-1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa) |
| | exos-9 | EXOSome (Multiexonuclease complex) component. (434 aa) |
| | ifc-1 | Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. (500 aa) |
| | F35G12.11 | Enhancer of rudimentary homolog; May have a role in the cell cycle. (113 aa) |
| | F33D11.10 | Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa) |
| | panl-2 | Uncharacterized protein F31E3.4. (1131 aa) |
| | exos-7 | RNase_PH domain-containing protein. (312 aa) |
| | rpt-2 | Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1. (443 aa) |
| | rars-1 | Probable arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. (713 aa) |
| | drsh-1 | Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa) |
| | hrpk-1 | Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. (397 aa) |
| | rrf-1 | RNA-dependent RNA polymerase Family. (1601 aa) |
| | ego-1 | RNA-directed RNA polymerase related EGO-1. (1632 aa) |
| | ncbp-2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap stru [...] (158 aa) |
| | eef-2 | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Involved in the morphogenesis of epidermal tissues; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic trans [...] (852 aa) |
| | mes-2 | Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] (773 aa) |
| | wago-1 | Argonaute protein wago-1; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G- RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts. (945 aa) |
| | rnp-4 | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa) |
| | ergo-1 | Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] (1121 aa) |
| | mag-1 | Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family. (152 aa) |
| | sup-26 | SUPpressor. (476 aa) |
| | pde-12 | Endo/exonuclease/phosphatase domain-containing protein. (628 aa) |
| | pelo-1 | Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity. (381 aa) |
| | hrde-2 | Protein hrde-2; Plays a role in germline RNA interference (RNAi), and in particular is required for piwi-interacting RNA (piRNA) gene silencing. Facilitates the binding of the argonaut protein hrde-1 to small interfering RNAs (siRNAs) targets that are required for transgenerational epigenetic inheritance and germline immortality. (305 aa) |
| | nrde-2 | Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs- mediated silencing in nuclei. Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription. Required for exogenous RNAi-induced H3K27 methylation. Belongs to the NRDE2 family. (1270 aa) |
| | kars-1 | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family. (596 aa) |
| | sma-9 | SMAll. (2232 aa) |
| | kgb-1 | GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa) |
| | eri-1 | 3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa) |
| | rrp-8 | Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (343 aa) |
| | jmjd-4 | JmjC domain-containing protein. (367 aa) |
| | fox-1 | Sex determination protein fox-1; A member of the sex determination pathway involved in making the distinction between one and two X-chromosomes. RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. Promotes binding of sup-12 to target RNA. (429 aa) |
| | alg-2 | Protein argonaute; Belongs to the argonaute family. (910 aa) |
| | rha-1 | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...] (1301 aa) |
| | sftb-1 | SF3b1 domain-containing protein. (1322 aa) |
| | cec-3 | Chromo domain-containing protein cec-3; Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc- 4 is expressed in the vulval but not in the non-vulval VC neurons. (339 aa) |
| | hrde-4 | Protein hrde-4; May play a role in transgenerational epigenetic inheritance. (545 aa) |
| | prp-19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa) |
| | spat-3 | RING-type domain-containing protein. (2476 aa) |
| | rde-4 | RNA interference promoting factor. (385 aa) |
| | pash-1 | PArtner of DroSHa (DRSH-1 interactor). (751 aa) |
| | alg-5 | Protein argonaute; Belongs to the argonaute family. (905 aa) |
| | gld-1 | Female germline-specific tumor suppressor gld-1; RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pa [...] (463 aa) |
| | nyn-1 | RNase_Zc3h12a_2 domain-containing protein. (500 aa) |
| | pir-1 | RNA/RNP complex-1-interacting phosphatase homolog; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity (By similarity). Binds RNA (By similarity). During small-RNA-mediated gene- silencing or RNA interference (RNAi), involved in the dcr-1-mediated processing of an amplified dsRNA intermediate. (233 aa) |
| | T25B9.9 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa) |
| | clec-38 | C-type LECtin. (382 aa) |
| | T26A5.8 | CBFD_NFYB_HMF domain-containing protein. (137 aa) |
| | eol-1 | RAI1 domain-containing protein. (316 aa) |
| | smg-5 | Nonsense-mediated mRNA decay protein. (549 aa) |
| | W03G9.2 | Uncharacterized protein. (515 aa) |
| | puf-9 | PUM-HD domain-containing protein. (703 aa) |
| | W08E3.2 | Btz domain-containing protein. (584 aa) |
| | mua-6 | Intermediate filament protein ifa-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle- cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos. (581 aa) |
| | efl-1 | E2F_TDP domain-containing protein; Belongs to the E2F/DP family. (342 aa) |
| | dcs-1 | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decap [...] (311 aa) |
| | fog-2 | F-box domain-containing protein. (327 aa) |
