STRINGSTRING
aat-9 aat-9 eat-4 eat-4 glt-1 glt-1 ctns-1 ctns-1 slc-36.5 slc-36.5 snf-9 snf-9 slc-25A29 slc-25A29 aat-5 aat-5 aat-2 aat-2 F13H10.3 F13H10.3 slc-25A18.1 slc-25A18.1 aat-8 aat-8 aat-7 aat-7 slc-25A18.2 slc-25A18.2 snf-2 snf-2 skat-1 skat-1 slc-36.4 slc-36.4 K02F3.2 K02F3.2 glt-3 glt-3 vglu-2 vglu-2 snf-6 snf-6 glt-6 glt-6 R07B7.10 R07B7.10 vglu-3 vglu-3 T10F2.2 T10F2.2 aat-6 aat-6 aat-4 aat-4 unc-47 unc-47 glt-4 glt-4 snf-12 snf-12 slc-36.2 slc-36.2 glt-7 glt-7 snf-10 snf-10 slc-36.3 slc-36.3 Y43F4B.7 Y43F4B.7 laat-1 laat-1 snf-5 snf-5 Y51F10.4 Y51F10.4 glt-5 glt-5 Y53F4B.12 Y53F4B.12 snf-7 snf-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aat-9Amino Acid Transporter. (541 aa)
eat-4Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa)
glt-1Excitatory amino acid transporter; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity). (503 aa)
ctns-1Cystinosin homolog; Thought to transport cystine out of lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells. (404 aa)
slc-36.5Aa_trans domain-containing protein. (489 aa)
snf-9Transporter. (713 aa)
slc-25A29SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (360 aa)
aat-5Amino Acid Transporter. (537 aa)
aat-2Amino Acid Transporter. (483 aa)
F13H10.3Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. (617 aa)
slc-25A18.1SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
aat-8Amino Acid Transporter. (483 aa)
aat-7Amino Acid Transporter. (500 aa)
slc-25A18.2SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
snf-2Transporter. (746 aa)
skat-1Probable amino acid transporter skat-1; Plays a role in the accumulation of vital dyes and endogenous fluorescent compounds in lysosome related organelles. Has an effect on lysosome related organelle (LRO) function, in a pathway with serotonin. (460 aa)
slc-36.4Aa_trans domain-containing protein. (481 aa)
K02F3.2Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. (716 aa)
glt-3Putative sodium-dependent excitatory amino acid transporter glt-3. (532 aa)
vglu-2MFS domain-containing protein. (573 aa)
snf-6Sodium-dependent acetylcholine transporter; Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-gly [...] (714 aa)
glt-6Putative sodium-dependent excitatory amino acid transporter glt-6. (542 aa)
R07B7.10Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (285 aa)
vglu-3Potential vesicular glutamate transporter vglu-3. (544 aa)
T10F2.2Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
aat-6Amino acid transporter protein 6; Amino acid transporter that mediates the uptake of the L- enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility. (523 aa)
aat-4Amino Acid Transporter. (526 aa)
unc-47Vesicular GABA transporter; Involved in the uptake of GABA into the synaptic vesicles. Belongs to the amino acid/polyamine transporter 2 family. (486 aa)
glt-4Putative sodium-dependent excitatory amino acid transporter glt-4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D- aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. (499 aa)
snf-12Transporter. (1022 aa)
slc-36.2Aa_trans domain-containing protein. (449 aa)
glt-7Amino acid transporter. (541 aa)
snf-10Transporter. (673 aa)
slc-36.3Aa_trans domain-containing protein. (454 aa)
Y43F4B.7Aa_trans domain-containing protein. (455 aa)
laat-1Lysosomal amino acid transporter 1; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function ; Belongs to the laat-1 family. (311 aa)
snf-5Sodium-dependent transporter snf-5; Sodium-dependent amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-proline and L-methionine, and also of acidic amino acids such as L-glutamic acid and L-aspartic acid (Probable). May additionally have a role in potassium-dependent amino acid absorption. In response to the availability of amino acid nutrients, may play a role in dauer formation. May play a role in promoting fertility. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (728 aa)
Y51F10.4Aa_trans domain-containing protein. (598 aa)
glt-5Amino acid transporter. (491 aa)
Y53F4B.12AA_permease domain-containing protein. (762 aa)
snf-7Transporter. (705 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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