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memb-1 memb-1 vamp-8 vamp-8 snx-1 snx-1 C06G3.6 C06G3.6 syx-6 syx-6 maa-1 maa-1 snb-5 snb-5 unc-11 unc-11 ric-19 ric-19 tbc-8 tbc-8 vps-8 vps-8 C56A3.8 C56A3.8 vps-32.1 vps-32.1 rab-8 rab-8 DH11.5 DH11.5 F07F6.4 F07F6.4 gos-28 gos-28 sec-24.1 sec-24.1 F13B9.1 F13B9.1 rme-8 rme-8 snb-2 snb-2 vps-41 vps-41 F32D8.14 F32D8.14 syx-3 syx-3 syx-7 syx-7 vps-60 vps-60 syx-2 syx-2 unc-108 unc-108 syx-5 syx-5 sec-22 sec-22 unc-64 unc-64 ccz-1 ccz-1 unc-26 unc-26 snap-29 snap-29 rab-14 rab-14 uso-1 uso-1 K11H3.4 K11H3.4 memb-2 memb-2 vps-11 vps-11 glo-1 glo-1 alx-1 alx-1 R12C12.5 R12C12.5 syx-4 syx-4 sec-31 sec-31 T05E7.3 T05E7.3 vps-39 vps-39 snb-1 snb-1 sqst-1 sqst-1 snb-6 snb-6 aex-4 aex-4 sqst-5 sqst-5 rund-1 rund-1 T23G11.7 T23G11.7 snt-4 snt-4 T24B8.2 T24B8.2 sqst-3 sqst-3 syx-17 syx-17 rab-7 rab-7 vps-18 vps-18 apd-3 apd-3 sec-23 sec-23 ric-4 ric-4 sqst-4 sqst-4 Y34B4A.2 Y34B4A.2 lst-4 lst-4 Y37D8A.25 Y37D8A.25 rabx-5 rabx-5 sqst-2 sqst-2 Y47G6A.18 Y47G6A.18 ced-1 ced-1 cccp-1 cccp-1 Y53F4B.21 Y53F4B.21 ral-1 ral-1 vti-1 vti-1 snx-6 snx-6 nbet-1 nbet-1 Y60A3A.19 Y60A3A.19 tfg-1 tfg-1 vps-20 vps-20 vamp-7 vamp-7 Y71A12B.10 Y71A12B.10 npp-20 npp-20 syx-16 syx-16 sec-24.2 sec-24.2 ZC8.6 ZC8.6 sar-1 sar-1 sec-16 sec-16 unc-13 unc-13 ZK632.12 ZK632.12 snb-7 snb-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
memb-1Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (213 aa)
vamp-8V-SNARE coiled-coil homology domain-containing protein. (116 aa)
snx-1PX domain-containing protein. (472 aa)
C06G3.6ZZ-type domain-containing protein. (498 aa)
syx-6Putative syntaxin 6; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (122 aa)
maa-1ACB domain-containing protein. (266 aa)
snb-5Synaptobrevin-like protein 5. (102 aa)
unc-11Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa)
ric-19Resistance to inhibitors of cholinesterase protein 19; May be involved in a role in neurotransmitter secretion. (430 aa)
tbc-8Rab-GAP TBC domain-containing protein. (913 aa)
vps-8Vps8 domain-containing protein. (1259 aa)
C56A3.8PI3K/PI4K domain-containing protein. (402 aa)
vps-32.1Related to yeast Vacuolar Protein Sorting factor. (221 aa)
rab-8RAB family. (211 aa)
DH11.5C2 domain-containing protein. (825 aa)
F07F6.4Uncharacterized protein F07F6.4; GTPase-activating protein for the ADP ribosylation factor family. (529 aa)
gos-28Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation. (234 aa)
sec-24.1Yeast SEC homolog. (1126 aa)
F13B9.1Protein transport protein sec16. (1632 aa)
rme-8J domain-containing protein. (2279 aa)
snb-2V-SNARE coiled-coil homology domain-containing protein. (114 aa)
vps-41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa)
F32D8.14Protein YIPF. (261 aa)
syx-3Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). (306 aa)
syx-7t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (248 aa)
vps-60Related to yeast Vacuolar Protein Sorting factor. (217 aa)
syx-2Putative syntaxin-2; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (299 aa)
unc-108Uncharacterized protein. (223 aa)
syx-5Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (413 aa)
sec-22Yeast SEC homolog; Belongs to the synaptobrevin family. (214 aa)
unc-64Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa)
ccz-1Uncharacterized protein. (528 aa)
unc-26Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa)
snap-29Soluble NSF attachment protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion; Belongs to the SNAP-25 family. (277 aa)
rab-14RAB family. (210 aa)
uso-1USO1 (Yeast transport protein) homolog. (941 aa)
K11H3.4Uncharacterized protein K11H3.4. (364 aa)
memb-2Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa)
vps-11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] (980 aa)
glo-1Gut granule LOss. (212 aa)
alx-1Apoptosis-linked gene 2-interacting protein X 1; Required for lin-12 degradation after it has been internalised in the vulval precursor cells. (882 aa)
R12C12.5Uncharacterized protein. (236 aa)
syx-4Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones. (296 aa)
sec-31WD_REPEATS_REGION domain-containing protein. (1083 aa)
T05E7.3Uncharacterized protein. (997 aa)
vps-39Vacuolar protein sorting-associated protein 39 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on th [...] (926 aa)
snb-1Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa)
sqst-1SeQueSTosome related. (693 aa)
snb-6V-SNARE coiled-coil homology domain-containing protein. (102 aa)
aex-4t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family. (234 aa)
sqst-5Protein ver-2; May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail. (192 aa)
rund-1RUN domain-containing protein. (549 aa)
T23G11.7Uncharacterized protein. (361 aa)
snt-4SyNapTotagmin. (381 aa)
T24B8.2Charged Multivesicular Body Protein homolog. (411 aa)
sqst-3ZZ-type domain-containing protein. (229 aa)
syx-17t-SNARE coiled-coil homology domain-containing protein. (250 aa)
rab-7RAB family. (209 aa)
vps-18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa)
apd-3AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa)
sec-23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (821 aa)
ric-4Synaptosomal-associated protein; Belongs to the SNAP-25 family. (234 aa)
sqst-4ZZ-type domain-containing protein. (177 aa)
Y34B4A.2Uncharacterized protein. (339 aa)
lst-4Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family. (592 aa)
Y37D8A.25PH domain-containing protein. (141 aa)
rabx-5RAB eXchange factor. (517 aa)
sqst-2ZZ-type domain-containing protein. (242 aa)
Y47G6A.18Uncharacterized protein. (280 aa)
ced-1Cell death abnormality protein 1; Involved in programmed cell death, also called apoptosis, in both somatic and germ cells. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria. (1111 aa)
cccp-1CARD domain-containing protein. (743 aa)
Y53F4B.21Uncharacterized protein. (1145 aa)
ral-1RAL (Ras-related GTPase) homolog. (254 aa)
vti-1t-SNARE coiled-coil homology domain-containing protein. (224 aa)
snx-6PX domain-containing protein. (478 aa)
nbet-1t-SNARE coiled-coil homology domain-containing protein. (107 aa)
Y60A3A.19Protein YIPF. (255 aa)
tfg-1PB1 domain-containing protein. (486 aa)
vps-20Related to yeast Vacuolar Protein Sorting factor. (208 aa)
vamp-7V-SNARE coiled-coil homology domain-containing protein. (261 aa)
Y71A12B.10PB1 domain-containing protein. (338 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa)
syx-16t-SNARE coiled-coil homology domain-containing protein. (329 aa)
sec-24.2Yeast SEC homolog. (984 aa)
ZC8.6PI3K/PI4K domain-containing protein. (593 aa)
sar-1GTP-binding protein SAR1; Involved in transport from the endoplasmic reticulum to the Golgi apparatus; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
sec-16Protein transport protein Sec16. (1232 aa)
unc-13Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa)
ZK632.12Uncharacterized protein ZK632.12. (266 aa)
snb-7V-SNARE coiled-coil homology domain-containing protein. (102 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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