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| | Y47H10A.3 | Uncharacterized protein. (333 aa) |
| | prp-4 | WD_REPEATS_REGION domain-containing protein. (496 aa) |
| | prp-8 | Pre-mRNA-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. (2329 aa) |
| | C50D2.5 | Splicing factor 3B subunit 6-like protein; Necessary for the splicing of pre-mRNA. (138 aa) |
| | C50D2.8 | Uncharacterized protein. (319 aa) |
| | syf-1 | SYF pre-mRNA splicing factor homolog. (855 aa) |
| | snr-4 | Probable small nuclear ribonucleoprotein Sm D2; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). (118 aa) |
| | C53A5.16 | Uncharacterized protein. (381 aa) |
| | dbr-1 | Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity); Belongs to the lariat debranching enzyme family. (500 aa) |
| | smu-1 | Smu-1 suppressor of mec-8 and unc-52 protein; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site. In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18. (510 aa) |
| | D1007.4 | Uncharacterized protein. (168 aa) |
| | nrd-1 | NRD (Yeast Nuclear pre-mRNA Down-regulation) homolog. (988 aa) |
| | cfim-2 | Cleavage Factor IM (CFIm) homolog. (491 aa) |
| | prp-38 | Yeast PRP (Splicing factor) related. (320 aa) |
| | plrg-1 | WD_REPEATS_REGION domain-containing protein. (494 aa) |
| | cdc-5L | Cell Division Cycle related. (755 aa) |
| | rsp-7 | Probable splicing factor, arginine/serine-rich 7. (452 aa) |
| | ptb-1 | Putative RNA-binding protein PTB-1a. (615 aa) |
| | E01A2.2 | Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity). (712 aa) |
| | rnp-1 | RNA-binding protein rnp-1; RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development. (305 aa) |
| | gld-4 | Poly(A) RNA polymerase gld-4; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. The enzymatic activity is enhanced by its interaction with gls-1. Required, together with gld-2, for early meiotic progression in male and female germ cells and for gld-1 protein accumulation in the hermaphrodite germline. In the germline, forms a complex with gls-1 which directly binds to gld-1 mRNA and prevents its degradation. (845 aa) |
| | snu-23 | Putative zinc finger matrin-type protein snu-23. (217 aa) |
| | snr-5 | Probable small nuclear ribonucleoprotein F; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. (85 aa) |
| | panl-3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (632 aa) |
| | lsm-7 | Sm domain-containing protein. (104 aa) |
| | fubl-2 | FUBp (FUBP) Like. (557 aa) |
| | pgl-1 | Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] (771 aa) |
| | eftu-2 | Tr-type G domain-containing protein. (974 aa) |
| | ZK1307.9 | Coiled-coil domain-containing protein 130 homolog. (369 aa) |
| | mett-10 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA) (By similarity). Involved in mRNA splicing (By similarity). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo. Belongs to the methyltransferase superfamily. METTL16/RlmF family. (479 aa) |
| | ZK1098.1 | WW domain-containing protein ZK1098.1. (724 aa) |
| | sym-2 | RNA-binding protein sym-2; mRNA splicing factor that regulates alternative splicing of many genes in embryo. Probably plays a role in the formation of embryo- specific isoforms; Belongs to the ESRP family. (618 aa) |
| | ccr-4 | Endo/exonuclease/phosphatase domain-containing protein. (677 aa) |
| | gld-2 | Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline. (1113 aa) |
| | ZC190.4 | SAM domain-containing protein. (629 aa) |
| | Y95B8A.8 | DZF domain-containing protein. (764 aa) |
| | uaf-1 | Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (496 aa) |
| | emb-4 | Uncharacterized protein. (1467 aa) |
| | cpsf-1 | Probable cleavage and polyadenylation specificity factor subunit 1; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). (1454 aa) |
| | ntl-11 | NOT-Like (Yeast CCR4/NOT complex component). (640 aa) |
| | sqd-1 | Homologous to Drosophila SQD (Squid) protein. (308 aa) |
| | lsm-8 | U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa) |
| | exos-2 | EXOSome (Multiexonuclease complex) component. (303 aa) |
| | smg-3 | Suppressor with Morphological effect on Genitalia. (1144 aa) |
| | tag-124 | Probable tRNA pseudouridine synthase tag-124; Formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (402 aa) |
| | mog-5 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5; Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. (1200 aa) |
| | rsp-4 | Probable splicing factor, arginine/serine-rich 4; May play a functionally redundant role in embryogenesis. Belongs to the splicing factor SR family. (196 aa) |
| | ddx-23 | DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (730 aa) |
| | skih-2 | SKI (Yeast SuperKIller) Helicase homolog. (1266 aa) |
| | F07H5.10 | RAI1 domain-containing protein. (334 aa) |
| | F08B4.7 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (142 aa) |
| | usp-39 | Ubiquitin Specific Protease. (602 aa) |
| | cpsf-2 | Probable cleavage and polyadenylation specificity factor subunit 2; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. (843 aa) |
| | F10B5.2 | Protein AAR2 homolog; Belongs to the AAR2 family. (357 aa) |
| | F10E7.5 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (220 aa) |
| | F10E9.5 | Uncharacterized protein F10E9.5. (199 aa) |
| | tsn-1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (914 aa) |
| | repo-1 | Matrin-type domain-containing protein. (222 aa) |
| | cpsf-4 | Cleavage and Polyadenylation Specificity Factor. (302 aa) |
| | F17A9.2 | CWF19-like protein 1 homolog; Belongs to the CWF19 family. (533 aa) |
| | puf-6 | Pumilio domain-containing protein 6; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (485 aa) |
| | F19F10.9 | Uncharacterized protein. (829 aa) |
| | smgl-1 | Uncharacterized protein. (1615 aa) |
| | F25B4.5 | Uncharacterized protein. (710 aa) |
| | symk-1 | SYMpleKin cleavage and polyadenylation factor. (1143 aa) |
| | ncbp-2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap stru [...] (158 aa) |
| | cpf-1 | WD_REPEATS_REGION domain-containing protein. (430 aa) |
| | suf-1 | Suf domain-containing protein. (735 aa) |
| | rsr-1 | PWI domain-containing protein. (601 aa) |
| | lsm-5 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA; Belongs to the snRNP Sm proteins family. (91 aa) |
| | F31C3.2 | PAP-associated domain-containing protein. (808 aa) |
| | exos-7 | RNase_PH domain-containing protein. (312 aa) |
| | panl-2 | Uncharacterized protein F31E3.4. (1131 aa) |
| | lsm-4 | Probable U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (123 aa) |
| | F32B6.3 | SFM domain-containing protein. (352 aa) |
| | fipp-1 | Fip1 domain-containing protein. (518 aa) |
| | let-858 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family. (897 aa) |
| | F33D11.10 | Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa) |
| | F33G12.2 | WD_REPEATS_REGION domain-containing protein. (305 aa) |
| | F33H1.3 | Uncharacterized protein F33H1.3. (359 aa) |
| | cdc-73 | Cell division cycle protein 73; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification; Belongs to the CDC73 family. (517 aa) |
| | cids-2 | CID domain-containing protein. (664 aa) |
| | ama-1 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa) |
| | rbpl-1 | Retinoblastoma Binding Protein Like. (1128 aa) |
| | F37C12.1 | Uncharacterized protein. (323 aa) |
| | exos-9 | EXOSome (Multiexonuclease complex) component. (434 aa) |
| | ncbp-1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa) |
| | F40F8.11 | DUF1768 domain-containing protein. (472 aa) |
| | lsm-1 | U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (125 aa) |
| | exos-8 | RNase_PH domain-containing protein. (277 aa) |
| | hrp-1 | Heterogeneous nuclear ribonucleoprotein A1; This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan. (347 aa) |
| | rpb-4 | RPOL4c domain-containing protein. (144 aa) |
| | F43G6.5 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa) |
| | patr-1 | Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family. (833 aa) |
| | mfap-1 | Microfibrillar-associated protein 1; Involved in pre-mRNA splicing. (466 aa) |
| | F43G9.12 | GCFC domain-containing protein. (809 aa) |
| | cfim-1 | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa) |
| | F43H9.3 | NTP_transf_2 domain-containing protein. (413 aa) |
| | tag-153 | NOT2_3_5 domain-containing protein. (733 aa) |
| | tdp-1 | Tar DNA-binding protein homolog 1; RNA-binding protein which regulates transcription, splicing and RNA-editing. Limits the accumulation of double- stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs. Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress. Involved in the regulation of physiological processes including aging, fertility, growth and locomotion. (414 aa) |
| | smg-4 | Smg4_UPF3 domain-containing protein. (368 aa) |
| | ubl-5 | Ubiquitin-like protein 5. (73 aa) |
| | F46H5.7 | Uncharacterized protein. (575 aa) |
| | disl-2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (848 aa) |
| | prp-17 | WD_REPEATS_REGION domain-containing protein. (567 aa) |
| | mog-3 | Sex determining protein MOG-3. (451 aa) |
| | dcap-2 | mRNA-decapping enzyme 2; RNA-decapping enzyme although it does not bind cap. May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs. Belongs to the Nudix hydrolase family. DCP2 subfamily. (786 aa) |
| | isy-1 | Protein isy-1; Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10. Does not affect the splicing of zip-10 ; Belongs to the ISY1 family. (267 aa) |
| | F53H1.1 | Uncharacterized protein. (970 aa) |
| | dom-3 | Decapping nuclease dom-3; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). (393 aa) |
| | spt-4 | Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. (120 aa) |
| | cpf-2 | RRM domain-containing protein. (336 aa) |
| | ddx-15 | Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. (739 aa) |
| | F56G4.4 | U1-type domain-containing protein. (470 aa) |
| | let-711 | Not1 domain-containing protein. (2641 aa) |
| | rbm-17 | RNA Binding Motif protein homolog. (371 aa) |
| | clpf-1 | Protein clpf-1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (428 aa) |
| | pup-3 | PAP-associated domain-containing protein. (482 aa) |
| | exos-3 | KH_dom_type_1 domain-containing protein. (226 aa) |
| | adr-1 | A-to-I RNA editing regulator adr-1; Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines. Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs. Represses editing efficiency of the Y75B8A.8 3' UTR in neurons. Required for correct expression and A-to-I editing of [...] (964 aa) |
| | mog-2 | Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing. (253 aa) |
| | sacy-1 | Suppressor of ACY-4 sterility; Belongs to the DEAD box helicase family. (630 aa) |
| | K01G5.5 | Putative H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family. (445 aa) |
| | teg-4 | CPSF_A domain-containing protein. (1220 aa) |
| | rnp-5 | RRM domain-containing protein. (289 aa) |
| | mog-1 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. (1131 aa) |
| | smg-8 | Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG8 family. (873 aa) |
| | rnp-7 | RRM domain-containing protein. (332 aa) |
| | syf-2 | Pre-mRNA-splicing factor syf-2; May be involved in pre-mRNA splicing. (234 aa) |
| | K07A1.15 | Sm domain-containing protein. (122 aa) |
| | K07C5.6 | Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Belongs to the SLU7 family. (647 aa) |
| | rnp-3 | RNP (RRM RNA binding domain) containing. (217 aa) |
| | rnp-2 | RNP (RRM RNA binding domain) containing. (206 aa) |
| | parn-1 | 3'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro. (566 aa) |
| | fubl-4 | FUBp (FUBP) Like. (586 aa) |
| | M01G12.14 | Uncharacterized protein. (350 aa) |
| | M01G12.7 | Uncharacterized protein. (460 aa) |
| | M01G12.9 | Uncharacterized protein. (469 aa) |
| | prp-3 | Yeast PRP (Splicing factor) related. (621 aa) |
| | M03F8.3 | Uncharacterized protein. (747 aa) |
| | rle-1 | Regulation of longevity by E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance. Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection. (952 aa) |
| | M28.5 | NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa) |
| | paxt-1 | Partner of xrn-2 protein 1; Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA in complex with the exoribonuclease xrn-2. Stabilizes and enhances the accumulation and activity of the exoribonuclease xrn-2, and thus contributes to miRNA turnover. (335 aa) |
| | snrp-27 | SNRNP27 domain-containing protein. (155 aa) |
| | edc-3 | DFDF domain-containing protein. (566 aa) |
| | R05D3.8 | Putative RNA-binding protein R05D3.8. (311 aa) |
| | pfs-2 | pre-mRNA 3' end processing protein pfs-2; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends (By similarity). Involved in neuron development, probably by regulating pre-mRNA 3'-end processing. (820 aa) |
| | R06C1.4 | RRM domain-containing protein. (84 aa) |
| | cdl-1 | Histone RNA hairpin-binding protein; Involved in histone pre-mRNA 3' processing. Required for chromosome condensation, progression of cell death and morphogenesis. (382 aa) |
| | R07E5.1 | G patch domain-containing protein 1 homolog. (812 aa) |
| | rnp-4 | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa) |
| | R08D7.1 | BUD13 homolog; Belongs to the CWC26 family. (458 aa) |
| | rbm-3.1 | RRM domain-containing protein. (83 aa) |
| | rbm-3.2 | RRM domain-containing protein. (85 aa) |
| | mag-1 | Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family. (152 aa) |
| | gkow-1 | G-patch domain and KOW motifs-containing protein homolog 1; Belongs to the MOS2 family. (462 aa) |
| | pcf-11 | Polyadenylation and cleavage factor homolog 11. (823 aa) |
| | pde-12 | Endo/exonuclease/phosphatase domain-containing protein. (628 aa) |
| | pnn-1 | Pinin_SDK_memA domain-containing protein. (359 aa) |
| | pelo-1 | Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity. (381 aa) |
| | etr-1 | RRM domain-containing protein. (589 aa) |
| | emb-5 | Suppressor of Ty 6 homolog; May regulate transcriptional elongation by RNA polymerase II. Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate; Belongs to the SPT6 family. (1521 aa) |
| | mel-46 | Helicase C-terminal domain-containing protein. (973 aa) |
| | fox-1 | Sex determination protein fox-1; A member of the sex determination pathway involved in making the distinction between one and two X-chromosomes. RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. Promotes binding of sup-12 to target RNA. (429 aa) |
| | rha-1 | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...] (1301 aa) |
| | sftb-1 | SF3b1 domain-containing protein. (1322 aa) |
| | rbm-5 | RNA Binding Motif protein homolog. (925 aa) |
| | cwc-15 | Spliceosome-associated protein CWC15 homolog; Component of a spliceosomal complex that is required for activating pre-mRNA splicing. (230 aa) |
| | prp-19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa) |
| | gut-2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (97 aa) |
| | bcas-2 | BCAS splicing factor homolog. (238 aa) |
| | glh-4 | ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development. (1156 aa) |
| | ssup-72 | RNA polymerase II subunit A C-terminal domain phosphatase ssup-72; Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1. By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre- mRNAs, including unc-44 and dlk-1 mRNAs. This results in the tissue-specific expression of unc-44 isoforms. (197 aa) |
| | T13H5.4 | Matrin-type domain-containing protein. (500 aa) |
| | T15H9.6 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa) |
| | adr-2 | Double-stranded RNA-specific adenosine deaminase adr-2; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Acts primarily on non-coding regions of protein- coding genes including introns and untranslated regions (UTR). Required for normal chemotaxis. Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis. Plays a role in determining lifespan. Not required for RNA interference. Likely to play a role in determining whether a dsRNA enters the RNAi pathway. (495 aa) |
| | pqbp-1.1 | WW domain-containing protein. (280 aa) |
| | asd-2 | RNA-binding protein asd-2; RNA-binding protein that binds to the 5'-NACUAAY-N(1,20)- UAAY-3' consensus sequence in pre-mRNA introns to promote alternative splicing. Required for mutually exclusive alternative splicing where it modulates the switch between mutually exclusive exons during pre-mRNA maturation. Involved in muscle-specific gene expression regulating the alternative splicing of genes such as let-2 and unc-60 to ensure that their respective isoforms are expressed in muscle. Promotes the removal of intron 10 from let-2 pre-mRNA to allow for the exclusive expression of the musc [...] (486 aa) |
| | sup-12 | RRM domain-containing protein. (248 aa) |
| | dnj-22 | J domain-containing protein. (296 aa) |
| | rbd-1 | RBD (RNA binding domain) protein. (872 aa) |
| | T23G11.4 | Uncharacterized protein. (240 aa) |
| | eol-1 | RAI1 domain-containing protein. (316 aa) |
| | skp-1 | Uncharacterized protein T27F2.1. (535 aa) |
| | snr-3 | Probable small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures (By similarity). Belongs to the snRNP core protein family. (126 aa) |
| | rsp-5 | Probable splicing factor, arginine/serine-rich 5; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites. (208 aa) |
| | rsp-2 | Probable splicing factor, arginine/serine-rich 2; Plays a functionally redundant role in spermatogenesis and growth rate control. Required for the development of somatic gonad structures and for progression from larval stage to adulthood. Belongs to the splicing factor SR family. (281 aa) |
| | rsp-1 | Probable splicing factor, arginine/serine-rich 1; Plays a functionally redundant role in spermatogenesis and growth rate control. (312 aa) |
| | smg-5 | Nonsense-mediated mRNA decay protein. (549 aa) |
| | sftb-2 | PSP domain-containing protein. (602 aa) |
| | cacn-1 | Cactin; Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis. (657 aa) |
| | rbm-25 | PWI domain-containing protein. (707 aa) |
| | puf-9 | PUM-HD domain-containing protein. (703 aa) |
| | pus-1 | PseudoU_synth_1 domain-containing protein. (415 aa) |
| | prp-21 | Yeast PRP (Splicing factor) related. (655 aa) |
| | snr-2 | Probable small nuclear ribonucleoprotein-associated protein B; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure (By similarity); Belongs to the snRNP SmB/SmN family. (160 aa) |
| | W08E3.2 | Btz domain-containing protein. (584 aa) |
| | pab-1 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (646 aa) |
| | Y108F1.5 | HA2 domain-containing protein. (330 aa) |
| | Y108G3AL.2 | Uncharacterized protein. (327 aa) |
| | prp-31 | Nop domain-containing protein. (504 aa) |
| | rsp-3 | Probable splicing factor, arginine/serine-rich 3; Plays an essential role in embryogenesis. (258 aa) |
| | dcs-1 | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decap [...] (311 aa) |
| | sfa-1 | CCHC-type domain-containing protein. (699 aa) |
| | uaf-2 | U2AF splicing factor. (285 aa) |
| | snr-1 | Small nuclear ribonucleoprotein Sm D3; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity); Belongs to the snRNP core protein family. (136 aa) |
| | Y119D3B.12 | Uncharacterized protein. (339 aa) |
| | car-1 | Cytokinesis, Apoptosis, RNA-associated. (340 aa) |
| | pap-1 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (655 aa) |
| | smgl-2 | Uncharacterized protein. (1089 aa) |
| | smi-1 | Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (254 aa) |
| | cdk-7 | Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (330 aa) |
| | sydn-1 | Synaptic defective enhancer 1; Acts as a negative regulator of nuclear pre-mRNA 3'-end processing (mRNA polyadenylation) (Probable). Plays a role in tissue-specific expression of protein isoforms by regulating differential processing of pre-mRNA 3'-end (alternative polyadenylation). In neurons, regulates alternative polyadenylation of specific mRNAs including unc- 44 and dlk-1 by interacting with phosphatase ssup-72 and thus preventing ssup-72 dephosphorylation of RNA polymerase II subunit ama-1. Specifically, alters the usage of internal polyadenylation sites (PAS) to promote the prod [...] (578 aa) |
| | xrn-1 | 5'-3' exoribonuclease 1. (1591 aa) |
| | Y40D12A.1 | Adrift-type SAM-dependent 2'-O-MTase domain-containing protein. (635 aa) |
| | Y44E3A.6 | FHA domain-containing protein. (843 aa) |
| | tiar-2 | TIA-1/TIAL RNA binding protein homolog. (434 aa) |
| | snrp-200 | Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2145 aa) |
| | ttc-37 | TeTratriCopeptide repeat domain protein related. (1114 aa) |
| | rnp-6 | RNP (RRM RNA binding domain) containing. (749 aa) |
| | Y47H10A.4 | Uncharacterized protein. (327 aa) |
| | Y47H10A.5 | Uncharacterized protein. (331 aa) |
| | xrn-2 | 5'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (975 aa) |
| | Y48G1C.9 | Sm domain-containing protein. (103 aa) |
| | smg-2 | Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity). (1069 aa) |
| | snr-6 | Probable small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (90 aa) |
| | smu-2 | Smu-2 suppressor of mec-8 and unc-52 protein; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1. Belongs to the RED family. (547 aa) |
| | Y50D4C.3 | Tudor domain-containing protein. (605 aa) |
| | Y53F4B.13 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. (918 aa) |
| | rpb-7 | S1 motif domain-containing protein. (197 aa) |
| | smg-9 | Protein smg-9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG9 family. (385 aa) |
| | smg-6 | PINc domain-containing protein. (1241 aa) |
| | phf-5 | PHd Finger family. (110 aa) |
| | Y54G2A.12 | WD_REPEATS_REGION domain-containing protein. (274 aa) |
| | Y54G2A.75 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa) |
| | Y54G9A.7 | 2O16. (244 aa) |
| | rbm-42 | RRM domain-containing protein. (302 aa) |
| | dcap-1 | mRNA_decap_C domain-containing protein. (332 aa) |
| | rbm-39 | RNA Binding Motif protein homolog. (580 aa) |
| | ntl-3 | NOT2_3_5 domain-containing protein. (701 aa) |
| | ccf-1 | CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family. (310 aa) |
| | nova-1 | KH domain-containing protein. (413 aa) |
| | prp-6 | Yeast PRP (Splicing factor) related. (968 aa) |
| | lsm-3 | U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa) |
| | cpsf-3 | Cleavage and Polyadenylation Specificity Factor. (707 aa) |
| | exos-4.2 | RNase_PH domain-containing protein. (241 aa) |
| | snr-7 | Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa) |
| | lsm-6 | Sm domain-containing protein; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa) |
| | smg-7 | TPR_REGION domain-containing protein. (458 aa) |
| | fubl-3 | FUBp (FUBP) Like. (641 aa) |
| | rsp-6 | Probable splicing factor, arginine/serine-rich 6; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood; Belongs to the splicing factor SR family. (179 aa) |
| | rbmx-2 | RRM domain-containing protein. (302 aa) |
| | C27H5.2 | TDP43_N domain-containing protein. (522 aa) |
| | ntl-9 | NOT-Like (Yeast CCR4/NOT complex component). (330 aa) |
| | hel-1 | Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly. (425 aa) |
| | tag-72 | mRNA cap guanine-N7 methyltransferase; mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. (380 aa) |
| | C24H11.5 | Uncharacterized protein. (92 aa) |
| | rsp-8 | RRM domain-containing protein. (309 aa) |
| | tiar-1 | RRM domain-containing protein. (408 aa) |
| | xol-1 | XO lethal protein 1; Acts as a primary sex-determining factor that promotes sexual differentiation. Absolutely required for proper sexual differentiation and male viability. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear; Belongs to the GHMP kinase family. Xol-1 subfamily. (426 aa) |
| | unc-75 | RRM domain-containing protein. (514 aa) |
| | thoc-2 | THO Complex (Transcription factor/nuclear export) subunit. (1437 aa) |
| | crn-5 | RNase_PH domain-containing protein. (214 aa) |
| | crn-3 | HRDC domain-containing protein. (876 aa) |
| | fubl-1 | FUBp (FUBP) Like. (611 aa) |
| | lin-41 | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa) |
| | sap-49 | Splicing factor 3B subunit 4; Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity). (388 aa) |
| | cgh-1 | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (430 aa) |
| | stip-1 | Septin and tuftelin-interacting protein 1 homolog; May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival. (830 aa) |
| | bud-31 | Protein BUD31 homolog; Involved in pre-mRNA splicing process. (147 aa) |
| | ain-1 | ALG-1 INteracting protein. (641 aa) |
| | mog-4 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4; ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis. (1008 aa) |
| | cel-1 | Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (623 aa) |
| | cids-1 | CID domain-containing protein 1. (315 aa) |
| | icln-1 | ICLN (ICLn) ion channel homolog. (225 aa) |
| | BE0003N10.1 | S1 motif domain-containing protein. (738 aa) |
| | exos-4.1 | Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events; Belongs to the RNase PH family. (240 aa) |
| | thoc-7 | THO Complex (Transcription factor/nuclear export) subunit. (210 aa) |
| | B0495.8 | Uncharacterized protein B0495.8; Belongs to the Luc7 family. (313 aa) |
| | spk-1 | Serine/threonine-protein kinase spk-1; Required for embryogenesis and germline development in both adult hermaphrodites and males. SR-protein kinase (SRPK) that binds directly to and phosphorylates the RS domain of rsp-3/CeSF2 in vitro. (1003 aa) |
| | B0361.2 | CWF19-like protein 2 homolog; Belongs to the CWF19 family. (460 aa) |
| | swp-1 | Protein SWAP; It is a regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). It may regulate its own expression at the level of RNA processing. (751 aa) |
| | rbm-26 | C3H1-type domain-containing protein. (721 aa) |
| | ntl-2 | NOT2_3_5 domain-containing protein. (444 aa) |
| | ain-2 | ALG-1 INteracting protein. (748 aa) |
| | sart-3 | SART-3/p110 homolog. (836 aa) |
| | C37H5.14 | RAI1 domain-containing protein. (322 aa) |
| | ire-1 | Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...] (967 aa) |
| | smn-1 | Tudor domain-containing protein. (207 aa) |
| | hrpl-1 | Heterogeneous nuclear RibonucleoProtein (HnRNP) L homolog. (597 aa) |
| | smg-1 | Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2. (2322 aa) |
| | C49H3.4 | Sm domain-containing protein. (223 aa) |
