Your Input: | |
| | skr-13 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | ZK993.5 | RING-type domain-containing protein. (439 aa) |
| | ZK993.2 | Uncharacterized protein. (488 aa) |
| | mel-26 | Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway. (399 aa) |
| | cul-5 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. (765 aa) |
| | ZK652.6 | Uncharacterized protein ZK652.6. (552 aa) |
| | ZK637.14 | Uncharacterized RING finger protein ZK637.14. (161 aa) |
| | cul-2 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] (791 aa) |
| | ZK430.7 | WD_REPEATS_REGION domain-containing protein. (444 aa) |
| | rbx-1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa) |
| | arc-1 | E3 ubiquitin-protein ligase arc-1; Acts as an E3 ubiquitin-protein ligase. (539 aa) |
| | dcaf-1 | DDB1- and CUL4-associated factor homolog 1; Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex. (1701 aa) |
| | ubq-2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) |
| | ZC13.1 | RING-type domain-containing protein. (398 aa) |
| | ubc-8 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (216 aa) |
| | Y92H12A.2 | E3 ubiquitin-protein ligase. (724 aa) |
| | ubc-14 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | eipr-1 | EARP-interacting protein 1; Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the endosome-associated recycling protein (EARP) complex. Important for neuronal function. Belongs to the WD repeat EIPR1 family. (362 aa) |
| | ari-1.4 | RBR-type E3 ubiquitin transferase. (485 aa) |
| | Y71H2AM.3 | Uncharacterized protein. (483 aa) |
| | ubc-3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (243 aa) |
| | Y71F9AL.10 | RING-type domain-containing protein. (189 aa) |
| | ubc-19 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (292 aa) |
| | eel-1 | Enhancer of EfL-1 mutant phenotype. (4185 aa) |
| | such-1 | Suppressor of spindle checkpoint defect 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis. Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells. Belongs to the APC5 family. (798 aa) |
| | wwp-1 | E3 ubiquitin-protein ligase. (794 aa) |
| | skr-4 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa) |
| | marc-5 | RING-CH-type domain-containing protein. (470 aa) |
| | Y57A10A.31 | RING-type domain-containing protein. (1180 aa) |
| | lep-2 | LEPtoderan male tail. (413 aa) |
| | ubc-13 | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa) |
| | ubc-16 | Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Together with ubc-18, required for the ubiquitination of membranous organelles, and the removal of paternal mitochondria from early embryos. (152 aa) |
| | Y54E10BR.3 | RING-type domain-containing protein. (304 aa) |
| | Y54E10A.11 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family. (1446 aa) |
| | Y53G8AR.5 | Uncharacterized protein. (287 aa) |
| | Y51F10.2 | RING-type domain-containing protein. (305 aa) |
| | Y49F6B.9 | RBR-type E3 ubiquitin transferase. (422 aa) |
| | herc-1 | HECT domain-containing protein. (1019 aa) |
| | Y48G1C.12 | DOC domain-containing protein. (216 aa) |
| | Y47G6A.14 | RING-type domain-containing protein. (468 aa) |
| | skr-14 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa) |
| | skr-7 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | plr-1 | Probable E3 ubiquitin-protein ligase plr-1; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non- canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG. Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the [...] (487 aa) |
| | mib-1 | MIB (MIndBomb) ubiquitin ligase homolog. (765 aa) |
| | Y45F10B.9 | RING-type domain-containing protein. (244 aa) |
| | Y45F10B.8 | RING-type domain-containing protein. (244 aa) |
| | Y40B1A.1 | WW domain-containing protein. (85 aa) |
| | oxi-1 | HECT domain-containing protein. (1066 aa) |
| | Y38F1A.2 | RING-type domain-containing protein. (283 aa) |
| | siah-1 | E3 ubiquitin-protein ligase siah-1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. (419 aa) |
| | rnf-145 | RING-type domain-containing protein. (742 aa) |
| | trf-2 | MATH domain-containing protein. (335 aa) |
| | mat-1 | Cell division cycle protein 27 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] (788 aa) |
| | ubc-26 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (238 aa) |
| | cul-3 | Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...] (777 aa) |
| | bath-40 | BTB and MATH domain-containing protein 40; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (402 aa) |
| | Y105E8A.14 | Uncharacterized protein. (224 aa) |
| | skr-10 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa) |
| | cand-1 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable). (1274 aa) |
| | mat-2 | Anaphase-promoting complex subunit 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors [...] (1505 aa) |
| | maea-1 | MAEA (MAcrophage Erythroblast Attacher protein) homolog. (428 aa) |
| | nhl-3 | B box-type domain-containing protein. (698 aa) |
| | kel-8 | Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ubiquitination and degradation of rpy-1. (727 aa) |
| | T27A3.7 | Phorbol-ester/DAG-type domain-containing protein. (373 aa) |
| | T22C1.1 | UBR-type domain-containing protein. (356 aa) |
| | T20F5.7 | RING-type domain-containing protein. (294 aa) |
| | T20F5.6 | RING-type domain-containing protein. (794 aa) |
| | bath-43 | BTB and MATH domain-containing protein 43; In complex with a cullin, may act in ubiquitination and proteasomal degradation processes. (451 aa) |
| | spat-3 | RING-type domain-containing protein. (2476 aa) |
| | ari-2 | Potential E3 ubiquitin-protein ligase ariadne-2; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBC-2/UBE2L3, and then transfers it to substrates. Belongs to the RBR family. Ariadne subfamily. (482 aa) |
| | prp-19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa) |
| | chn-1 | C-term of Hsp70-iNteracting protein (CHIP family). (266 aa) |
| | T07D1.2 | Zf-RING_UBOX domain-containing protein. (432 aa) |
| | ufd-2 | Ubiquitin conjugation factor E4 ufd-2; Acts as an E4 ubiquitin ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. The elongation of preexisting ubiquitin chains preferentially targets ubiquitin 'Lys-29' and 'Lys-48' residues. Also functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Probably by regulating protein ubiquitination at DNA damage repair sites, coordinates DNA double- strand-break repair and apoptosis in the germline. Required for germline apoptosis in response to DNA damage downstream of cep [...] (984 aa) |
| | T05A12.4 | Uncharacterized protein. (1622 aa) |
| | T02C1.2 | RING-type domain-containing protein. (275 aa) |
| | T02C1.1 | Uncharacterized RING finger protein T02C1.1. (160 aa) |
| | T01G5.7 | RING-type domain-containing protein. (260 aa) |
| | T01C3.3 | RING-type domain-containing protein. (230 aa) |
| | skr-20 | SKp1 Related (Ubiquitin ligase complex component). (173 aa) |
| | skr-19 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa) |
| | rbx-2 | RING-type domain-containing protein. (112 aa) |
| | ebax-1 | SWIM-type domain-containing protein. (1717 aa) |
| | ubc-12 | NEDD8-conjugating enzyme ubc-12; Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins. Plays a role in male tail tip morphogenesis. (180 aa) |
| | R08B4.3 | Protein yippee-like; Belongs to the yippee family. (154 aa) |
| | R05G6.4 | Nitric oxide synthase-interacting protein homolog; Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity; Belongs to the NOSIP family. (310 aa) |
| | rfp-1 | E3 ubiquitin-protein ligase bre-1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Belongs to the BRE1 family. (837 aa) |
| | ubc-18 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (153 aa) |
| | let-70 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short- lived and abnormal proteins. Plays a role in the DNA damage response. In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms ; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | M18.6 | CULT domain-containing protein. (414 aa) |
| | ddb-1 | DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. (1134 aa) |
| | gfi-3 | Protein gfi-3; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Required for the metaphase to anaphase transition in meiosis. (800 aa) |
| | rle-1 | Regulation of longevity by E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance. Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection. (952 aa) |
| | M110.3 | RING-CH-type domain-containing protein. (189 aa) |
| | sli-1 | Suppressor of LIneage defect. (582 aa) |
| | K11D12.9 | RING-type domain-containing protein. (400 aa) |
| | emb-1 | Anaphase-promoting complex subunit emb-1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. May be required for germline proliferation. Required for male tail development and hermaphrodite vulva formation. (81 aa) |
| | lin-23 | F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). (667 aa) |
| | cul-6 | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa) |
| | pdr-1 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa) |
| | apc-2 | Anaphase-promoting complex subunit 2; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. (731 aa) |
| | brd-1 | BRCA1-associated RING domain protein 1; Involved in ubiquitination. Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. Involved in DNA repair. Has a reactive role in the response to DNA damage by ionizing radiation. Protects against chromosome non-disjunction and fragmentation to aid chromosome stability. (702 aa) |
| | dre-1 | F-box protein dre-1; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including blmp-1. Heterochronic protein which is required for the timing of gonad development and epidermal seam cell differentiation. Regulates tail-spike cell death through inhibition of the apoptosis regulator ced-9. (1022 aa) |
| | rnf-113 | Probable E3 ubiquitin-protein ligase rnf113; May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents. (384 aa) |
| | H10E21.5 | RING-type domain-containing protein. (473 aa) |
| | ubl-1 | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa) |
| | cyn-4 | Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. (523 aa) |
| | zif-1 | Zinc finger-interacting factor 1; Probable substrate recognition component of a CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2. (489 aa) |
| | marc-1 | RING-CH-type domain-containing protein. (206 aa) |
| | par-2 | RING-type domain-containing protein. (582 aa) |
| | ubc-7 | Probable ubiquitin-conjugating enzyme E2 7; Catalyzes the covalent attachment of ubiquitin to other proteins. (164 aa) |
| | F57C12.2 | RING-type domain-containing protein. (281 aa) |
| | F56D2.5 | RBR-type E3 ubiquitin transferase. (437 aa) |
| | uev-2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (230 aa) |
| | F56D2.2 | RBR-type E3 ubiquitin transferase. (451 aa) |
| | skr-18 | Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa) |
| | marc-6 | RING-CH-type domain-containing protein. (1025 aa) |
| | sel-11 | E3 ubiquitin-protein ligase hrd-1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play [...] (610 aa) |
| | nhl-1 | RING finger protein nhl-1. (974 aa) |
| | skr-15 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa) |
| | emb-30 | Abnormal embryogenesis protein 30; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells. Required for embryonic anterior- posterior axis formation. Negatively regulat [...] (1027 aa) |
| | F54B11.5 | RING-type domain-containing protein. (201 aa) |
| | F52C6.3 | Ubiquitin-like domain-containing protein. (197 aa) |
| | ubc-24 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (160 aa) |
| | skr-5 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa) |
| | skr-2 | SKp1 Related (Ubiquitin ligase complex component). (174 aa) |
| | hecw-1 | E3 ubiquitin-protein ligase hecw-1; E3 ubiquitin-protein ligase (By similarity). Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P.aeruginosa although worms do display avoidance behavior, vacating a P.aeruginosa lawn within 24 hours. Likely to act by inhibiting the neuropeptide receptor npr-1. (1247 aa) |
| | trf-1 | TNF Receptor Associated Factor (TRAF) homolog. (462 aa) |
| | cul-4 | Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. (840 aa) |
| | sel-1 | Suppressor/Enhancer of Lin-12. (685 aa) |
| | skr-3 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa) |
| | F42A6.5 | BRCT domain-containing protein. (102 aa) |
| | ubc-20 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa) |
| | F40G9.14 | RING-type domain-containing protein. (261 aa) |
| | uev-1 | Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] (139 aa) |
| | bath-41 | BTB and MATH domain-containing protein 41; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (418 aa) |
| | rbpl-1 | Retinoblastoma Binding Protein Like. (1128 aa) |
| | ubr-5 | UBR E3 ubiquitin ligase homolog. (2944 aa) |
| | apc-11 | Anaphase-promoting complex subunit 11; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity. Belongs to the RING-box family. (135 aa) |
| | fem-1 | Sex-determining protein fem-1; Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin- protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1. (656 aa) |
| | F33H12.1 | BRCT domain-containing protein. (295 aa) |
| | uev-3 | Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination (By similarity). May modulate the activity of the p38 MAP kinase pnk-3. May have a role in axon termination and synaptic transmission at motor and mechanosensory neurons. Plays a role in intraflagellar transport in cilia and cilium length regulation ; Belongs to the ubiquitin-conjugating enzyme family. (368 aa) |
| | tam-1 | RING-type domain-containing protein. (944 aa) |
| | nhl-2 | NHL (Ring finger b-box coiled coil) domain containing. (1032 aa) |
| | hrdl-1 | E3 ubiquitin-protein ligase hrd-like protein 1; Proposed to have a role in neuroprotection. (579 aa) |
| | ubc-25 | Ubiquitin-conjugating enzyme E2 25; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function. (387 aa) |
| | ubq-1 | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa) |
| | peli-1 | PELI1 and PELI2 related. (458 aa) |
| | F16A11.1 | Uncharacterized protein. (673 aa) |
| | tag-314 | RBR-type E3 ubiquitin transferase. (404 aa) |
| | apc-10 | Anaphase-promoting complex subunit 10; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. (212 aa) |
| | mig-32 | RING-type domain-containing protein. (549 aa) |
| | F10G7.10 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2025 aa) |
| | F10D7.5 | NHR domain-containing protein. (617 aa) |
| | mat-3 | Cell division cycle protein 23 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptor [...] (673 aa) |
| | emb-27 | Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...] (655 aa) |
| | vhl-1 | Von Hippel-Lindau tumor suppressor homolog; Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size. Mediates resistance to enteropathogenic E.coli. Mediates susceptibility to B.thuringiensis pore-forming toxins. Not involved in P.aeruginosa susceptibility. Belongs to the VHL family. (174 aa) |
| | prx-12 | Putative peroxisome assembly protein 12; Required for protein import into peroxisomes; Belongs to the pex2/pex10/pex12 family. (344 aa) |
| | F07B7.12 | Uncharacterized protein. (1964 aa) |
| | brap-2 | BRCA1-associated protein homolog 2; Controls the stress response to increased levels of reactive oxygen species by modulating the brc-1-dependent expression of cki-1. (590 aa) |
| | mfb-1 | F-box domain-containing protein. (379 aa) |
| | marc-2 | RING-CH-type domain-containing protein. (206 aa) |
| | etc-1 | E3 ubiquitin-protein ligase etc-1; E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos. (1001 aa) |
| | cul-1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa) |
| | csa-1 | Cockayne Syndrome complementation group A homolog. (360 aa) |
| | ubc-6 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (314 aa) |
| | C55A6.1 | Uncharacterized protein. (228 aa) |
| | marc-4 | RING-CH-type domain-containing protein. (317 aa) |
| | C52E12.1 | RING-type domain-containing protein. (925 aa) |
| | skr-8 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-9 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-12 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | bath-42 | BTB and MATH domain-containing protein 42; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (410 aa) |
| | ntl-4 | NOT-Like (Yeast CCR4/NOT complex component). (798 aa) |
| | uba-1 | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1113 aa) |
| | C45G7.4 | RING-type domain-containing protein. (603 aa) |
| | ubr-4 | UBR-type domain-containing protein. (4218 aa) |
| | skr-16 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa) |
| | madd-2 | Uncharacterized protein. (765 aa) |
| | swah-1 | ANK_REP_REGION domain-containing protein. (298 aa) |
| | C36B1.9 | RING-type domain-containing protein. (674 aa) |
| | brc-1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] (612 aa) |
| | ubc-1 | Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (192 aa) |
| | C34F6.7 | Uncharacterized protein. (411 aa) |
| | hecd-1 | E3 ubiquitin-protein ligase hecd-1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins. Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision. Negatively regulates glp-1 activity in germline proliferation. May play a role in the formation of fibrous organelles, a hemidesmosome-like s [...] (2650 aa) |
| | ubr-1 | E3 ubiquitin-protein ligase ubr-1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N- end rule, leading to their ubiquitination and subsequent degradation (By similarity). In complex with ced-3, required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 to regulate seam cell fate patterning during larval development. Negatively regulates glutamate metabolism through the aspartate aminotrans [...] (2058 aa) |
| | C32D5.10 | Uncharacterized RING finger protein C32D5.10. (610 aa) |
| | C28G1.10 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (203 aa) |
| | ari-1.1 | RBR-type E3 ubiquitin transferase. (494 aa) |
| | ari-1.2 | RBR-type E3 ubiquitin transferase. (497 aa) |
| | ari-1.3 | RBR-type E3 ubiquitin transferase. (491 aa) |
| | fsn-1 | F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...] (332 aa) |
| | C26B9.6 | Uncharacterized protein. (306 aa) |
| | C17H11.6 | RBR-type E3 ubiquitin transferase. (893 aa) |
| | C17H11.4 | Uncharacterized protein. (115 aa) |
| | marc-3 | RING-CH-type domain-containing protein. (431 aa) |
| | C16C8.4 | Ubiquitin-like domain-containing protein. (226 aa) |
| | rnf-5 | E3 ubiquitin ligase rnf-5; E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the en [...] (235 aa) |
| | rnf-121 | RING finger protein 121; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the RNF121 family. (335 aa) |
| | C14B1.3 | Uncharacterized protein. (384 aa) |
| | lin-41 | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa) |
| | C11H1.3 | RING-type domain-containing protein. (529 aa) |
| | C10E2.2 | Uncharacterized protein. (501 aa) |
| | apc-17 | Anaphase Promoting Complex see also mat. (325 aa) |
| | bath-15 | BTB and MATH domain-containing protein 15; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (313 aa) |
| | ubc-22 | UBiquitin Conjugating enzyme. (182 aa) |
| | ubc-21 | Probable ubiquitin-conjugating enzyme E2 21; Catalyzes the covalent attachment of ubiquitin to other proteins. (214 aa) |
| | skr-17 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa) |
| | rnf-1 | RING-type domain-containing protein. (381 aa) |
| | C06A5.8 | RING-type domain-containing protein. (283 aa) |
| | C02B8.6 | Uncharacterized RING finger protein C02B8.6. (347 aa) |
| | C01G6.4 | RING-type domain-containing protein. (170 aa) |
| | rpm-1 | E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] (3766 aa) |
| | BE0003N10.3 | UBR-type domain-containing protein. (719 aa) |
| | cdc-26 | Anaphase-promoting complex subunit CDC26; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. Required for embryonic anterior-posterior axis formation. Belongs to the CDC26 family. (194 aa) |
| | B0432.13 | RING-type domain-containing protein. (451 aa) |
| | ubc-17 | Probable ubiquitin-conjugating enzyme protein 17; Belongs to the ubiquitin-conjugating enzyme family. (728 aa) |
