STRINGSTRING
exc-7 exc-7 vab-23 vab-23 syd-9 syd-9 rnp-1 rnp-1 sor-1 sor-1 uaf-1 uaf-1 sut-2 sut-2 rsr-2 rsr-2 rsy-1 rsy-1 sydn-1 sydn-1 rsp-3 rsp-3 W08E3.2 W08E3.2 rsp-2 rsp-2 rsp-5 rsp-5 rbd-1 rbd-1 sup-12 sup-12 nrde-2 nrde-2 rnp-4 rnp-4 pfs-2 pfs-2 K04F10.7 K04F10.7 cpf-2 cpf-2 let-858 let-858 F32B6.3 F32B6.3 rsp-4 rsp-4 sop-2 sop-2 prp-4 prp-4 hecd-1 hecd-1 rsp-6 rsp-6 unc-75 unc-75 let-756 let-756 B0511.7 B0511.7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
exc-7Uncharacterized protein. (456 aa)
vab-23Uncharacterized protein. (253 aa)
syd-9C2H2-type domain-containing protein. (537 aa)
rnp-1RNA-binding protein rnp-1; RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development. (305 aa)
sor-1Sop-2-related protein 1; Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner. (1000 aa)
uaf-1Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (496 aa)
sut-2Zinc finger CCCH domain-containing protein 14. (740 aa)
rsr-2Cwf21 domain-containing protein. (425 aa)
rsy-1Regulator of SYnapse formation. (589 aa)
sydn-1Synaptic defective enhancer 1; Acts as a negative regulator of nuclear pre-mRNA 3'-end processing (mRNA polyadenylation) (Probable). Plays a role in tissue-specific expression of protein isoforms by regulating differential processing of pre-mRNA 3'-end (alternative polyadenylation). In neurons, regulates alternative polyadenylation of specific mRNAs including unc- 44 and dlk-1 by interacting with phosphatase ssup-72 and thus preventing ssup-72 dephosphorylation of RNA polymerase II subunit ama-1. Specifically, alters the usage of internal polyadenylation sites (PAS) to promote the prod [...] (578 aa)
rsp-3Probable splicing factor, arginine/serine-rich 3; Plays an essential role in embryogenesis. (258 aa)
W08E3.2Btz domain-containing protein. (584 aa)
rsp-2Probable splicing factor, arginine/serine-rich 2; Plays a functionally redundant role in spermatogenesis and growth rate control. Required for the development of somatic gonad structures and for progression from larval stage to adulthood. Belongs to the splicing factor SR family. (281 aa)
rsp-5Probable splicing factor, arginine/serine-rich 5; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites. (208 aa)
rbd-1RBD (RNA binding domain) protein. (872 aa)
sup-12RRM domain-containing protein. (248 aa)
nrde-2Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs- mediated silencing in nuclei. Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription. Required for exogenous RNAi-induced H3K27 methylation. Belongs to the NRDE2 family. (1270 aa)
rnp-4RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa)
pfs-2pre-mRNA 3' end processing protein pfs-2; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends (By similarity). Involved in neuron development, probably by regulating pre-mRNA 3'-end processing. (820 aa)
K04F10.7Uncharacterized protein. (293 aa)
cpf-2RRM domain-containing protein. (336 aa)
let-858Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family. (897 aa)
F32B6.3SFM domain-containing protein. (352 aa)
rsp-4Probable splicing factor, arginine/serine-rich 4; May play a functionally redundant role in embryogenesis. Belongs to the splicing factor SR family. (196 aa)
sop-2Polycomb protein sop-2; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA. (737 aa)
prp-4WD_REPEATS_REGION domain-containing protein. (496 aa)
hecd-1E3 ubiquitin-protein ligase hecd-1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins. Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision. Negatively regulates glp-1 activity in germline proliferation. May play a role in the formation of fibrous organelles, a hemidesmosome-like s [...] (2650 aa)
rsp-6Probable splicing factor, arginine/serine-rich 6; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood; Belongs to the splicing factor SR family. (179 aa)
unc-75RRM domain-containing protein. (514 aa)
let-756Protein let-756; Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development. (425 aa)
B0511.7FHA domain-containing protein. (302 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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