node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F42A6.5 | brc-1 | F42A6.5.1 | C36A4.8a.1 | BRCT domain-containing protein. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] | 0.778 |
bckd-1B | dbt-1 | F27D4.5.1 | ZK669.4.1 | Transket_pyr domain-containing protein. | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxyl [...] | 0.999 |
brc-1 | F42A6.5 | C36A4.8a.1 | F42A6.5.1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] | BRCT domain-containing protein. | 0.778 |
dbt-1 | bckd-1B | ZK669.4.1 | F27D4.5.1 | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxyl [...] | Transket_pyr domain-containing protein. | 0.999 |
hsf-1 | nhr-80 | Y53C10A.12.1 | H10E21.3b.1 | HSF_DOMAIN domain-containing protein. | Nuclear Hormone Receptor family. | 0.532 |
mdt-15 | nhr-49 | R12B2.5a.1 | K10C3.6c.2 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.983 |
mdt-15 | nhr-80 | R12B2.5a.1 | H10E21.3b.1 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | Nuclear Hormone Receptor family. | 0.817 |
mdt-15 | paqr-1 | R12B2.5a.1 | C43G2.1c.1 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | Progestin and adipoQ receptor-like protein 1; Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Belongs to the ADIPOR family. | 0.693 |
mdt-15 | paqr-2 | R12B2.5a.1 | Y32H12A.5.1 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | Progestin and AdipoQ Receptor family. | 0.759 |
mod-1 | nhr-76 | K06C4.6a.1 | C05G6.1.1 | Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.660 |
mod-1 | ser-6 | K06C4.6a.1 | Y54G2A.35a.1 | Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.852 |
nhr-49 | mdt-15 | K10C3.6c.2 | R12B2.5a.1 | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | 0.983 |
nhr-49 | nhr-76 | K10C3.6c.2 | C05G6.1.1 | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | 0.748 |
nhr-49 | nhr-80 | K10C3.6c.2 | H10E21.3b.1 | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | Nuclear Hormone Receptor family. | 0.891 |
nhr-49 | paqr-1 | K10C3.6c.2 | C43G2.1c.1 | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | Progestin and adipoQ receptor-like protein 1; Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Belongs to the ADIPOR family. | 0.694 |
nhr-49 | paqr-2 | K10C3.6c.2 | Y32H12A.5.1 | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | Progestin and AdipoQ Receptor family. | 0.767 |
nhr-76 | mod-1 | C05G6.1.1 | K06C4.6a.1 | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | Serotonin-gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.660 |
nhr-76 | nhr-49 | C05G6.1.1 | K10C3.6c.2 | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.748 |
nhr-76 | ser-6 | C05G6.1.1 | Y54G2A.35a.1 | Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.776 |
nhr-80 | hsf-1 | H10E21.3b.1 | Y53C10A.12.1 | Nuclear Hormone Receptor family. | HSF_DOMAIN domain-containing protein. | 0.532 |