STRINGSTRING
zhp-4 zhp-4 ubc-9 ubc-9 zhp-1 zhp-1 uev-2 uev-2 zhp-3 zhp-3 R06C7.2 R06C7.2 gei-17 gei-17 zhp-2 zhp-2 ZK1248.11 ZK1248.11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
zhp-4Zip (Yeast meiotic zipper) Homologous Protein. (283 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
zhp-1Zip (Yeast meiotic zipper) Homologous Protein. (220 aa)
uev-2UBIQUITIN_CONJUGAT_2 domain-containing protein. (230 aa)
zhp-3RING-type domain-containing protein. (389 aa)
R06C7.2Uncharacterized protein. (233 aa)
gei-17E3 SUMO-protein ligase gei-17; Functions as an E3-type smo-1 ligase. Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment. In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation. In embryos, plays a role in determining telomere localization in the nucleus. (780 aa)
zhp-2RING-type domain-containing protein. (240 aa)
ZK1248.11SP-RING-type domain-containing protein. (201 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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