STRINGSTRING
cpx-2 cpx-2 unc-76 unc-76 snb-5 snb-5 snap-1 snap-1 sue-1 sue-1 vps-52 vps-52 snb-2 snb-2 unc-18 unc-18 snt-1 snt-1 snt-2 snt-2 sly-1 sly-1 cla-1 cla-1 lgl-1 lgl-1 snap-29 snap-29 vps-51 vps-51 tom-1 tom-1 snt-5 snt-5 T07A9.10 T07A9.10 snt-7 snt-7 snb-1 snb-1 snb-6 snb-6 aex-4 aex-4 vps-54 vps-54 T22C1.6 T22C1.6 T27E4.1 T27E4.1 ric-4 ric-4 Y59A8B.8 Y59A8B.8 vamp-7 vamp-7 cpx-1 cpx-1 snt-3 snt-3 unc-13 unc-13 snb-7 snb-7 Y59A8B.25 Y59A8B.25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cpx-2ComPleXin (Synaptic protein) homolog. (87 aa)
unc-76Uncharacterized protein. (388 aa)
snb-5Synaptobrevin-like protein 5. (102 aa)
snap-1SNAP (Soluble NSF Attachment Protein) homolog. (295 aa)
sue-1SUppressor of Elongation defect. (537 aa)
vps-52Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS52 family. (702 aa)
snb-2V-SNARE coiled-coil homology domain-containing protein. (114 aa)
unc-18Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family. (591 aa)
snt-1Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa)
snt-2Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa)
sly-1SLY1 homolog; Belongs to the STXBP/unc-18/SEC1 family. (675 aa)
cla-1Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...] (8922 aa)
lgl-1LLGL domain-containing protein. (941 aa)
snap-29Soluble NSF attachment protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion; Belongs to the SNAP-25 family. (277 aa)
vps-51Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS51 family. (700 aa)
tom-1LLGL domain-containing protein. (1255 aa)
snt-5SyNapTotagmin. (458 aa)
T07A9.10Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (562 aa)
snt-7C2 domain-containing protein. (416 aa)
snb-1Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa)
snb-6V-SNARE coiled-coil homology domain-containing protein. (102 aa)
aex-4t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family. (234 aa)
vps-54Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. (1058 aa)
T22C1.6Uncharacterized protein. (335 aa)
T27E4.1Uncharacterized protein. (309 aa)
ric-4Synaptosomal-associated protein; Belongs to the SNAP-25 family. (234 aa)
Y59A8B.8Uncharacterized protein. (299 aa)
vamp-7V-SNARE coiled-coil homology domain-containing protein. (261 aa)
cpx-1Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family. (143 aa)
snt-3SyNapTotagmin. (284 aa)
unc-13Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa)
snb-7V-SNARE coiled-coil homology domain-containing protein. (102 aa)
Y59A8B.25Uncharacterized protein. (145 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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