17 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dab-1	PID domain-containing protein. (492 aa)
	zmp-2	Matrix metalloproteinase-B; Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol. (519 aa)
	myrf-1	Myelin regulatory factor homolog 1, C-terminal; [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 1, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] (931 aa)
	cpz-1	Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family. (306 aa)
	lrp-1	Low-density lipoprotein receptor-related protein; May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin; Belongs to the LDLR family. (4753 aa)
	gsr-1	Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting. (473 aa)
	apl-1	Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] (686 aa)
	acn-1	Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...] (906 aa)
	mlt-3	ANK_REP_REGION domain-containing protein. (392 aa)
	nas-37	Zinc metalloproteinase nas-37; Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Required during ecdysis, the opening of the cuticle to allow the worm to escape. (765 aa)
	trxr-1	Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting. (667 aa)
	mlt-2	ANK_REP_REGION domain-containing protein. (668 aa)
	vps-34	Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa)
	mlt-4	ANK_REP_REGION domain-containing protein. (624 aa)
	imp-2	Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. (468 aa)
	lin-29	Transcription factor. (459 aa)
	mab-10	Uncharacterized protein. (582 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
dab-1	lrp-1	M110.5b.2	F29D11.1.1	PID domain-containing protein.	Low-density lipoprotein receptor-related protein; May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin; Belongs to the LDLR family.	0.813
lin-29	mab-10	W03C9.4a.1	R166.1a.1	Transcription factor.	Uncharacterized protein.	0.971
lrp-1	dab-1	F29D11.1.1	M110.5b.2	Low-density lipoprotein receptor-related protein; May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin; Belongs to the LDLR family.	PID domain-containing protein.	0.813
mab-10	lin-29	R166.1a.1	W03C9.4a.1	Uncharacterized protein.	Transcription factor.	0.971
mlt-2	mlt-3	C01H6.2.1	Y39C12A.1.1	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.985
mlt-2	mlt-4	C01H6.2.1	ZC15.7.1	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.689
mlt-3	mlt-2	Y39C12A.1.1	C01H6.2.1	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.985
mlt-3	mlt-4	Y39C12A.1.1	ZC15.7.1	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.608
mlt-4	mlt-2	ZC15.7.1	C01H6.2.1	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.689
mlt-4	mlt-3	ZC15.7.1	Y39C12A.1.1	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.608