STRINGSTRING
B0273.115 B0273.115 C18B2.1 C18B2.1 C18B2.2 C18B2.2 C31B8.9 C31B8.9 chst-1 chst-1 sqv-7 sqv-7 C54F6.3 C54F6.3 F01D5.10 F01D5.10 F17B5.4 F17B5.4 F20C5.7 F20C5.7 F25E5.2 F25E5.2 F36D1.8 F36D1.8 F40C5.1 F40C5.1 F49D11.3 F49D11.3 F49D11.6 F49D11.6 F55B12.2 F55B12.2 F56H6.13 F56H6.13 F56H6.4 F56H6.4 F59D12.3 F59D12.3 K06H6.5 K06H6.5 K07H8.8 K07H8.8 mig-22 mig-22 sqv-3 sqv-3 T09E11.3 T09E11.3 T15D6.1 T15D6.1 T24A6.16 T24A6.16 sqv-5 sqv-5 T27C5.12 T27C5.12 sqv-2 sqv-2 Y48G1BL.7 Y48G1BL.7 sqv-6 sqv-6 Y87G2A.16 Y87G2A.16 ZK1025.2 ZK1025.2 ZK1025.8 ZK1025.8 sqv-8 sqv-8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B0273.115Uncharacterized protein. (127 aa)
C18B2.1Uncharacterized protein C18B2.1. (321 aa)
C18B2.2Uncharacterized protein C18B2.2. (356 aa)
C31B8.9Uncharacterized protein. (270 aa)
chst-1Carbohydrate sulfotransferase chst-1; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residue of chondroitin. (329 aa)
sqv-7UDP-sugar transporter sqv-7; Involved in the import of UDP-glucuronic acid (UDP-GlcA), UDP-N-acetylgalactosamine (UDP-GalNAc) and UDP-galactose (UDP-Gal) from the cytoplasm into the Golgi lumen for the biosynthesis of glycoconjugates that play a pivotal role in development. Involved in the synthesis of chondroitin sulfate and heparan sulfate proteoglycans. Required for embryonic development. Involved in vulva epithelium invagination and embryonic development. Involved in the directed migration of hermaphrodite-specific neurons. Belongs to the TPT transporter family. SLC35D subfamily. (329 aa)
C54F6.3Uncharacterized protein. (314 aa)
F01D5.10Uncharacterized protein. (347 aa)
F17B5.4Uncharacterized protein. (278 aa)
F20C5.7Uncharacterized protein. (308 aa)
F25E5.2Uncharacterized protein. (338 aa)
F36D1.8Uncharacterized protein. (329 aa)
F40C5.1Uncharacterized protein. (309 aa)
F49D11.3Uncharacterized protein. (314 aa)
F49D11.6Uncharacterized protein. (314 aa)
F55B12.2Uncharacterized protein. (327 aa)
F56H6.13Uncharacterized protein. (311 aa)
F56H6.4Uncharacterized protein. (316 aa)
F59D12.3Uncharacterized protein. (318 aa)
K06H6.5Uncharacterized protein. (339 aa)
K07H8.8Uncharacterized protein. (318 aa)
mig-22Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...] (804 aa)
sqv-3Xylosylprotein 4-beta-galactosyltransferase; Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate. Required for embryonic development. Involved in vulval epithelium invagination ; Belongs to the glycosyltransferase 7 family. (289 aa)
T09E11.3Uncharacterized protein. (305 aa)
T15D6.1Uncharacterized protein. (302 aa)
T24A6.16Uncharacterized protein. (309 aa)
sqv-5Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...] (736 aa)
T27C5.12Uncharacterized protein. (309 aa)
sqv-2Beta-1,3-galactosyltransferase sqv-2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis. (330 aa)
Y48G1BL.7Uncharacterized protein. (319 aa)
sqv-6Xylosyltransferase sqv-6; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis. (806 aa)
Y87G2A.16Uncharacterized protein. (356 aa)
ZK1025.2Uncharacterized protein. (301 aa)
ZK1025.8annotation not available (301 aa)
sqv-8Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8; Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate. May be involved in the biosynthesis of the HNK-1 carbohydrate epitope on glycoproteins. Required for embryonic development. Involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development. Involved in vulval epithelium invagination. (356 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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