STRINGSTRING
snt-6 snt-6 hipr-1 hipr-1 snt-3 snt-3 apb-1 apb-1 Y45G5AM.9 Y45G5AM.9 apg-1 apg-1 dnj-25 dnj-25 T27E4.1 T27E4.1 snt-4 snt-4 chc-1 chc-1 apa-2 apa-2 snt-7 snt-7 clic-1 clic-1 epn-1 epn-1 dpy-23 dpy-23 snt-5 snt-5 dab-1 dab-1 unc-101 unc-101 ced-6 ced-6 apm-1 apm-1 cla-1 cla-1 snt-2 snt-2 snt-1 snt-1 tag-138 tag-138 sue-1 sue-1 aps-2 aps-2 DH11.5 DH11.5 rsd-3 rsd-3 unc-11 unc-11 unc-41 unc-41 C07A12.7 C07A12.7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
snt-6C2 domain-containing protein. (373 aa)
hipr-1Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family. (927 aa)
snt-3SyNapTotagmin. (284 aa)
apb-1AP complex subunit beta. (955 aa)
Y45G5AM.9Uncharacterized protein. (499 aa)
apg-1AP-1 complex subunit gamma. (829 aa)
dnj-25J domain-containing protein. (784 aa)
T27E4.1Uncharacterized protein. (309 aa)
snt-4SyNapTotagmin. (381 aa)
chc-1Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa)
apa-2AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa)
snt-7C2 domain-containing protein. (416 aa)
clic-1Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa)
epn-1ENTH domain-containing protein. (469 aa)
dpy-23AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...] (441 aa)
snt-5SyNapTotagmin. (458 aa)
dab-1PID domain-containing protein. (492 aa)
unc-101AP-1 complex subunit mu-1-I; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (Probable). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (Probable). Required for many aspects of development and behavior, including negative regulation of vulval differentiation. Required for the dendritic localization of potassium channel kvs-4 in the cholinergic motor neuron DA9. (422 aa)
ced-6Cell death protein 6; May function as an adapter protein in a pathway that mediates recognition and phagocytosis of apoptotic cells during normal development. Promotes engulfment of cells at both early and late stages of apoptosis. Required for actin reorganization around apoptotic cells. Belongs to the ced-6 family. (492 aa)
apm-1MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (426 aa)
cla-1Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...] (8922 aa)
snt-2Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa)
snt-1Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa)
tag-138ENTH domain-containing protein. (362 aa)
sue-1SUppressor of Elongation defect. (537 aa)
aps-2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
DH11.5C2 domain-containing protein. (825 aa)
rsd-3ENTH domain-containing protein. (483 aa)
unc-11Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa)
unc-41Putative stoned B-like protein; Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles; Belongs to the Stoned B family. (1693 aa)
C07A12.7GAT domain-containing protein. (437 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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