node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
R10E4.9 | let-767 | R10E4.9.1 | C56G2.6c.1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.679 |
R10E4.9 | stdh-1 | R10E4.9.1 | C06B3.4.1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.687 |
R10E4.9 | stdh-2 | R10E4.9.1 | F11A5.12.1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.678 |
R10E4.9 | stdh-3 | R10E4.9.1 | C06B3.5.1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.678 |
R10E4.9 | stdh-4 | R10E4.9.1 | F25G6.5b.1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] | Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.678 |
elo-1 | elo-2 | F56H11.4a.1 | F11E6.5.1 | Elongation of very long chain fatty acids protein. | Elongation of very long chain fatty acids protein. | 0.558 |
elo-1 | elo-3 | F56H11.4a.1 | D2024.3.1 | Elongation of very long chain fatty acids protein. | Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family. | 0.505 |
elo-1 | elo-4 | F56H11.4a.1 | C40H1.4.1 | Elongation of very long chain fatty acids protein. | Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family. | 0.552 |
elo-1 | elo-5 | F56H11.4a.1 | F41H10.7.2 | Elongation of very long chain fatty acids protein. | Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. | 0.530 |
elo-1 | elo-6 | F56H11.4a.1 | F41H10.8.1 | Elongation of very long chain fatty acids protein. | Elongation of very long chain fatty acids protein 6; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isoheptadecanoate (C17iso). | 0.520 |
elo-1 | elo-7 | F56H11.4a.1 | F56H11.3.1 | Elongation of very long chain fatty acids protein. | Elongation of very long chain fatty acids protein. | 0.465 |
elo-1 | elo-9 | F56H11.4a.1 | Y53F4B.2.1 | Elongation of very long chain fatty acids protein. | Elongation of very long chain fatty acids protein. | 0.543 |
elo-1 | fat-2 | F56H11.4a.1 | W02A2.1a.2 | Elongation of very long chain fatty acids protein. | Delta(12) fatty acid desaturase fat-2; Catalyzes the desaturation of oleic acid (Delta(9)-18:1, or C18:1(n-9)) to linoleic acid (Delta(9,12)-18:2, or C18:2(n-6)). This desaturation event is essential for the synthesis of longer chain polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA, or C20:4(n-6)) and eicosapentaenoic acid (EPA, or C20:5(n-3)). | 0.767 |
elo-1 | let-767 | F56H11.4a.1 | C56G2.6c.1 | Elongation of very long chain fatty acids protein. | Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.918 |
elo-1 | stdh-1 | F56H11.4a.1 | C06B3.4.1 | Elongation of very long chain fatty acids protein. | Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.698 |
elo-1 | stdh-2 | F56H11.4a.1 | F11A5.12.1 | Elongation of very long chain fatty acids protein. | Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.698 |
elo-1 | stdh-3 | F56H11.4a.1 | C06B3.5.1 | Elongation of very long chain fatty acids protein. | Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.698 |
elo-1 | stdh-4 | F56H11.4a.1 | F25G6.5b.1 | Elongation of very long chain fatty acids protein. | Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.698 |
elo-2 | elo-1 | F11E6.5.1 | F56H11.4a.1 | Elongation of very long chain fatty acids protein. | Elongation of very long chain fatty acids protein. | 0.558 |
elo-2 | elo-3 | F11E6.5.1 | D2024.3.1 | Elongation of very long chain fatty acids protein. | Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family. | 0.513 |