(14 nodes) Hsp70 protein binding network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F42A6.6	DUF775 domain-containing protein. (219 aa)
	dnj-26	J domain-containing protein. (365 aa)
	Y22D7AL.9	TPR_REGION domain-containing protein. (836 aa)
	skn-1	Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
	hip-1	TPR_REGION domain-containing protein. (422 aa)
	chn-1	C-term of Hsp70-iNteracting protein (CHIP family). (266 aa)
	dnj-19	DNaJ domain (Prokaryotic heat shock protein). (439 aa)
	sti-1	Stress-induced-phosphoprotein 1; Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity. (320 aa)
	F47G9.4	Probable RING finger protein 207 homolog. (822 aa)
	dnj-12	DNaJ domain (Prokaryotic heat shock protein). (402 aa)
	dnj-11	DNaJ domain (Prokaryotic heat shock protein). (589 aa)
	pcrg-1	Parkin Co-Regulated Gene (PACRG) homolog. (294 aa)
	ttc-4	TeTratriCopeptide repeat domain protein related. (419 aa)
	dnj-1	DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily. (401 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F42A6.6	dnj-11	F42A6.6a.1	F38A5.13.1	DUF775 domain-containing protein.	DNaJ domain (Prokaryotic heat shock protein).	0.401
Y22D7AL.9	dnj-12	Y22D7AL.9.1	F39B2.10.2	TPR_REGION domain-containing protein.	DNaJ domain (Prokaryotic heat shock protein).	0.465
Y22D7AL.9	dnj-19	Y22D7AL.9.1	T05C3.5.2	TPR_REGION domain-containing protein.	DNaJ domain (Prokaryotic heat shock protein).	0.465
chn-1	hip-1	T09B4.10.2	T12D8.8.2	C-term of Hsp70-iNteracting protein (CHIP family).	TPR_REGION domain-containing protein.	0.714
dnj-1	dnj-11	B0035.14a.2	F38A5.13.1	DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	DNaJ domain (Prokaryotic heat shock protein).	0.462
dnj-1	dnj-12	B0035.14a.2	F39B2.10.2	DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	DNaJ domain (Prokaryotic heat shock protein).	0.427
dnj-1	dnj-19	B0035.14a.2	T05C3.5.2	DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	DNaJ domain (Prokaryotic heat shock protein).	0.429
dnj-11	F42A6.6	F38A5.13.1	F42A6.6a.1	DNaJ domain (Prokaryotic heat shock protein).	DUF775 domain-containing protein.	0.401
dnj-11	dnj-1	F38A5.13.1	B0035.14a.2	DNaJ domain (Prokaryotic heat shock protein).	DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	0.462
dnj-11	dnj-12	F38A5.13.1	F39B2.10.2	DNaJ domain (Prokaryotic heat shock protein).	DNaJ domain (Prokaryotic heat shock protein).	0.452
dnj-11	dnj-19	F38A5.13.1	T05C3.5.2	DNaJ domain (Prokaryotic heat shock protein).	DNaJ domain (Prokaryotic heat shock protein).	0.828
dnj-11	dnj-26	F38A5.13.1	Y39C12A.8.1	DNaJ domain (Prokaryotic heat shock protein).	J domain-containing protein.	0.470
dnj-12	Y22D7AL.9	F39B2.10.2	Y22D7AL.9.1	DNaJ domain (Prokaryotic heat shock protein).	TPR_REGION domain-containing protein.	0.465
dnj-12	dnj-1	F39B2.10.2	B0035.14a.2	DNaJ domain (Prokaryotic heat shock protein).	DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	0.427
dnj-12	dnj-11	F39B2.10.2	F38A5.13.1	DNaJ domain (Prokaryotic heat shock protein).	DNaJ domain (Prokaryotic heat shock protein).	0.452
dnj-12	dnj-19	F39B2.10.2	T05C3.5.2	DNaJ domain (Prokaryotic heat shock protein).	DNaJ domain (Prokaryotic heat shock protein).	0.790
dnj-12	sti-1	F39B2.10.2	R09E12.3.1	DNaJ domain (Prokaryotic heat shock protein).	Stress-induced-phosphoprotein 1; Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity.	0.895
dnj-19	Y22D7AL.9	T05C3.5.2	Y22D7AL.9.1	DNaJ domain (Prokaryotic heat shock protein).	TPR_REGION domain-containing protein.	0.465
dnj-19	dnj-1	T05C3.5.2	B0035.14a.2	DNaJ domain (Prokaryotic heat shock protein).	DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.	0.429
dnj-19	dnj-11	T05C3.5.2	F38A5.13.1	DNaJ domain (Prokaryotic heat shock protein).	DNaJ domain (Prokaryotic heat shock protein).	0.828