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| | unc-31 | Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion. Involved in regulating entry into quiescence triggered by sat [...] (1401 aa) |
| | sorf-1 | Suppressor of organelle fusion 1; Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR91 family. (239 aa) |
| | unc-13 | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa) |
| | eat-4 | Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa) |
| | sec-16 | Protein transport protein Sec16. (1232 aa) |
| | ptr-23 | SSD domain-containing protein. (983 aa) |
| | sar-1 | GTP-binding protein SAR1; Involved in transport from the endoplasmic reticulum to the Golgi apparatus; Belongs to the small GTPase superfamily. SAR1 family. (193 aa) |
| | vps-29 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (191 aa) |
| | sec-24.2 | Yeast SEC homolog. (984 aa) |
| | unc-17 | Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (532 aa) |
| | lmtr-2 | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family. (124 aa) |
| | vps-28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa) |
| | ptr-22 | SSD domain-containing protein. (888 aa) |
| | npp-20 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa) |
| | snt-3 | SyNapTotagmin. (284 aa) |
| | Y71H2AM.2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (251 aa) |
| | Y71G12A.4 | AB hydrolase-1 domain-containing protein. (468 aa) |
| | copa-1 | Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1232 aa) |
| | smf-3 | NRAMP-like transporter smf-3; Probable divalent metal ion transporter which regulates the uptake of several heavy metals such as Mn(2+), Al(3+) and iron. Plays a role in modulating Al(3+)-induced dopamine (DA) neuron degeneration through the intracellular sequestration of Al(3+). (560 aa) |
| | ptr-21 | SSD domain-containing protein. (909 aa) |
| | vps-20 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | vti-1 | t-SNARE coiled-coil homology domain-containing protein. (224 aa) |
| | marc-5 | RING-CH-type domain-containing protein. (470 aa) |
| | ptr-20 | SSD domain-containing protein. (860 aa) |
| | spe-48 | UBA domain-containing protein. (337 aa) |
| | Y50D4A.4 | Mic1 domain-containing protein. (628 aa) |
| | tat-1 | Phospholipid-transporting ATPase tat-1; Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintainence and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifica [...] (1192 aa) |
| | aps-3 | Clat_adaptor_s domain-containing protein. (192 aa) |
| | ced-1 | Cell death abnormality protein 1; Involved in programmed cell death, also called apoptosis, in both somatic and germ cells. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria. (1111 aa) |
| | rab-35 | RAB family. (209 aa) |
| | vps-2 | Related to yeast Vacuolar Protein Sorting factor. (237 aa) |
| | Y45G5AM.9 | Uncharacterized protein. (499 aa) |
| | Y41E3.18 | Hydrolase_4 domain-containing protein. (481 aa) |
| | Y41C4A.32 | WD_REPEATS_REGION domain-containing protein. (291 aa) |
| | ttm-1 | Zinc transporter ttm-1; Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc. Involved in cadmium resistance, possibly by promoting its transport from cells. Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway. (410 aa) |
| | ptr-19 | SSD domain-containing protein. (1003 aa) |
| | ptr-18 | SSD domain-containing protein. (895 aa) |
| | snn-1 | ATP-grasp domain-containing protein. (474 aa) |
| | lst-4 | Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family. (592 aa) |
| | vps-4 | Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. (430 aa) |
| | Y25C1A.7 | Yip1 domain-containing protein. (414 aa) |
| | copb-1 | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (971 aa) |
| | cnt-1 | Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6. (826 aa) |
| | arf-6 | ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family. (175 aa) |
| | sec-23 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (821 aa) |
| | ncap-1 | DUF1681 domain-containing protein. (236 aa) |
| | apg-1 | AP-1 complex subunit gamma. (829 aa) |
| | odr-4 | Odorant response abnormal protein 4; Required, with oct-8, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Regulates chemotaxis responses to benzaldehyde, diacetyl and 2,4,5- trimethylthiazole in AWA and AWC neurons. Plays a role in nociceptive neurons to mediate avoidance of high oxygen. (475 aa) |
| | apd-3 | AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1251 aa) |
| | rme-1 | Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa) |
| | snx-3 | PX domain-containing protein. (162 aa) |
| | vps-18 | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa) |
| | rab-7 | RAB family. (209 aa) |
| | sel-9 | Suppressor/enhancer of lin-12 protein 9; May have a role in the negative regulation of lin-12 and glp- 1 transport to the cell surface. May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles. Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction. Belongs to the EMP24/GP25L family. (203 aa) |
| | vps-25 | Related to yeast Vacuolar Protein Sorting factor. (183 aa) |
| | cat-1 | MFS domain-containing protein. (553 aa) |
| | ppk-3 | PIP Kinase. (1497 aa) |
| | vps-24 | Related to yeast Vacuolar Protein Sorting factor. (208 aa) |
| | T24B8.2 | Charged Multivesicular Body Protein homolog. (411 aa) |
| | rab-10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa) |
| | T23G11.7 | Uncharacterized protein. (361 aa) |
| | atg-9 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (921 aa) |
| | ptr-16 | SSD domain-containing protein. (898 aa) |
| | sma-10 | Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size. (881 aa) |
| | unc-47 | Vesicular GABA transporter; Involved in the uptake of GABA into the synaptic vesicles. Belongs to the amino acid/polyamine transporter 2 family. (486 aa) |
| | chc-1 | Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa) |
| | apa-2 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (925 aa) |
| | cdf-2 | Cation Diffusion Facilitator family. (360 aa) |
| | tsp-12 | Tetraspanin-12; Together with tsp-14, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling. May regulate BMP-like Sma/Mab signaling by mediating protease sup-17 trafficking to the cell surface. Together with tsp-14, probably acts by modulating the activation of glp-1, a Notch-like receptor, to regulate germline maturation. Probably acts by modulating the activation of lin-12, a Notch-like receptor, to regulate cell fate specification such as the anchor cell/ventral uteri [...] (308 aa) |
| | T14G10.5 | Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (885 aa) |
| | dop-3 | Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1. (607 aa) |
| | rme-2 | Receptor Mediated Endocytosis. (925 aa) |
| | snb-1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa) |
| | snt-7 | C2 domain-containing protein. (416 aa) |
| | T10B10.3 | Uncharacterized protein. (741 aa) |
| | vps-39 | Vacuolar protein sorting-associated protein 39 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on th [...] (926 aa) |
| | sng-1 | Synaptogyrin homolog 1; Belongs to the synaptogyrin family. (247 aa) |
| | ptr-15 | SSD domain-containing protein. (840 aa) |
| | vglu-3 | Potential vesicular glutamate transporter vglu-3. (544 aa) |
| | vps-53 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. (798 aa) |
| | clic-1 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa) |
| | epn-1 | ENTH domain-containing protein. (469 aa) |
| | sec-31 | WD_REPEATS_REGION domain-containing protein. (1083 aa) |
| | lst-2 | Lateral signaling target protein 2; Negative regulator of epidermal growth factor receptor (EGFR) signaling; Belongs to the lst-2 family. (661 aa) |
| | dpy-23 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...] (441 aa) |
| | lmtr-5 | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (95 aa) |
| | R12C12.5 | Uncharacterized protein. (236 aa) |
| | apb-3 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (945 aa) |
| | R10E11.6 | Uncharacterized protein R10E11.6. (371 aa) |
| | ptr-14 | SSD domain-containing protein. (877 aa) |
| | chat-1 | CDC50 family protein chat-1; Probable chaperone protein for the phospholipid-transporting ATPase tat-1. Regulates cell membrane structure and function. Plays a role in maintaining the membrane phosphatidylserine asymmetry and the formation of the tubular membrane structure. Involved in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo and this is likely with the phospholipid-transporting ATPase tat-1. (348 aa) |
| | R07E5.19 | Vacuolar ATPase assembly integral membrane protein VMA21 homolog; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (102 aa) |
| | glo-1 | Gut granule LOss. (212 aa) |
| | vps-11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] (980 aa) |
| | mig-14 | Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...] (549 aa) |
| | hrg-1 | Heme transporter hrg-1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. Belongs to the HRG family. (194 aa) |
| | egg-2 | LDL receptor repeat-containing protein egg-2; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-1, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-1 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...] (548 aa) |
| | memb-2 | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa) |
| | scm-1 | Secretory carrier-associated membrane protein. (335 aa) |
| | tom-1 | LLGL domain-containing protein. (1255 aa) |
| | smf-1 | NRAMP-like transporter smf-1; Probable divalent metal ion transporter which regulates Mn(2+) uptake; Belongs to the NRAMP family. (562 aa) |
| | smf-2 | NRAMP-like transporter smf-2; Probable divalent metal ion transporter which regulates Mn(2+) uptake. (546 aa) |
| | unc-101 | AP-1 complex subunit mu-1-I; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (Probable). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (Probable). Required for many aspects of development and behavior, including negative regulation of vulval differentiation. Required for the dendritic localization of potassium channel kvs-4 in the cholinergic motor neuron DA9. (422 aa) |
| | unc-68 | Uncharacterized protein. (5202 aa) |
| | vglu-2 | MFS domain-containing protein. (573 aa) |
| | uso-1 | USO1 (Yeast transport protein) homolog. (941 aa) |
| | rab-14 | RAB family. (210 aa) |
| | uda-1 | Nucleoside-diphosphatase uda-1; Hydrolyzes UDP and GDP but not any other nucleoside di-, mono- or triphosphates. May promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum; Belongs to the GDA1/CD39 NTPase family. (479 aa) |
| | ptr-13 | SSD domain-containing protein. (851 aa) |
| | ptr-12 | SSD domain-containing protein. (901 aa) |
| | vacl-14 | VAC (Yeast VACuole morphology)-Like. (694 aa) |
| | aho-3 | Alpha/beta hydrolase domain-containing protein aho-3; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (By similarity). Acts in sensory neurons including AWC to regulate starvation-induced thermotaxis plasticity and salt learning behavior; Belongs to the AB hydrolase superfamily. ABHD17 family. (332 aa) |
| | tmem-135 | Transmembrane protein 135 homolog; Involved in fat storage. (445 aa) |
| | tbh-1 | Tyramine beta-hydroxylase; Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity. Belongs to the copper type II ascorbate-dependent monooxygenase family. (657 aa) |
| | glo-3 | Gut granule loss protein 3. (607 aa) |
| | sam-4 | Uncharacterized protein. (240 aa) |
| | copz-1 | Probable coatomer subunit zeta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its associatio [...] (184 aa) |
| | nhx-5 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (630 aa) |
| | ptr-11 | SSD domain-containing protein. (820 aa) |
| | F55H2.5 | Putative cytochrome b561. (266 aa) |
| | ptr-10 | SSD domain-containing protein. (900 aa) |
| | rfip-1 | FIP-RBD domain-containing protein. (471 aa) |
| | sec-22 | Yeast SEC homolog; Belongs to the synaptobrevin family. (214 aa) |
| | ptr-9 | Patched-related protein 9; Belongs to the patched family. (844 aa) |
| | ina-1 | Integrin alpha ina-1; Plays a role in cell migration, axon fasciculation, and morphogenesis. During gonad morphogenesis, involved in distal tip cells (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p. Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis. Belongs to the integrin alpha chain family. (1139 aa) |
| | rab-11.1 | Ras-related protein rab-11.1; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in regulating the meiotic maturation of oocytes. Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization. Controls cor [...] (211 aa) |
| | strl-1 | Steroidogenic acute regulatory-like protein 1. (259 aa) |
| | F52E1.9 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (181 aa) |
| | sorf-2 | Suppressor of organelle fusion 2; Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR81 family. (1422 aa) |
| | ptr-24 | SSD domain-containing protein. (892 aa) |
| | cope-1 | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (292 aa) |
| | cla-1 | Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...] (8922 aa) |
| | sdpn-1 | SynDaPiN (Synaptic dynamin binding protein) homolog. (495 aa) |
| | ptr-8 | SSD domain-containing protein. (890 aa) |
| | F43D9.1 | SSD domain-containing protein. (1226 aa) |
| | snt-2 | Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. (369 aa) |
| | sph-1 | MARVEL domain-containing protein. (227 aa) |
| | F41H10.4 | Uncharacterized protein. (575 aa) |
| | atg-18 | Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...] (412 aa) |
| | piki-1 | Phosphatidylinositol 3-kinase piki-1; Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3- phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes; Belongs to the PI3/PI4-kinase family. (1607 aa) |
| | copb-2 | Probable coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity); Belongs to the WD repeat COPB2 family. (1000 aa) |
| | itr-1 | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa) |
| | vps-41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane [...] (901 aa) |
| | daf-6 | SSD domain-containing protein. (913 aa) |
| | snt-1 | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death. (443 aa) |
| | aps-1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa) |
| | rab-5 | RAB family. (208 aa) |
| | tag-340 | Uncharacterized protein. (447 aa) |
| | ehbp-1 | EH (Eps-15-homology) domain Binding Protein family. (901 aa) |
| | did-2 | Doa4-Independent Degradation, homologous to yeast Did2. (205 aa) |
| | F20D1.1 | Uncharacterized protein. (166 aa) |
| | rme-8 | J domain-containing protein. (2279 aa) |
| | snx-17 | Sorting nexin-17 homolog; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (540 aa) |
| | vps-36 | GLUE N-terminal domain-containing protein. (383 aa) |
| | sid-5 | Systemic RNA interference defective protein 5; Plays a role in RNA-mediated gene silencing by mediating transport of both ingested and endogenous dsRNA between cells. Not required for the uptake of dsRNA from the intestinal lumen. (67 aa) |
| | F13H10.3 | Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. (617 aa) |
| | F13B9.1 | Protein transport protein sec16. (1632 aa) |
| | sec-24.1 | Yeast SEC homolog. (1126 aa) |
| | aps-2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa) |
| | F01D5.8 | Hydrolase_4 domain-containing protein. (362 aa) |
| | F01D5.7 | Hydrolase_4 domain-containing protein. (342 aa) |
| | sup-17 | Disintegrin and metalloproteinase domain-containing protein 10 homolog; Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification. By modulating lin-12/Notch signaling, plays a role in germline development. Probably by modulating BMP-like Sma/Mab signaling via the shedding of unc-40 ectodomain, involved in the regulation of body size and mesoderm development. Probably b [...] (922 aa) |
| | mctp-1 | Multiple C2 and Transmembrane region Protein family homolog. (822 aa) |
| | scp-1 | SREBP Cleavage activating Protein (SCAP) homolog. (1087 aa) |
| | rab-8 | RAB family. (211 aa) |
| | aka-1 | FYVE-type domain-containing protein. (1284 aa) |
| | vps-37 | VPS37 C-terminal domain-containing protein. (234 aa) |
| | CD4.11 | Uncharacterized protein. (496 aa) |
| | vps-32.1 | Related to yeast Vacuolar Protein Sorting factor. (221 aa) |
| | epg-5 | Ectopic P granules protein 5; Involved in the maturation of autophagosomes into autolysosomes during starvation-induced autotrophy. Specifically, involved in the clearance of apoptotic cells by promoting the delivery of engulfed apoptotic cells to the lysosome. (1599 aa) |
| | vps-33.2 | Vacuolar protein sorting-associated protein 33B; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a rab-5 effector to mediate early endoso [...] (617 aa) |
| | ptr-6 | SSD domain-containing protein. (982 aa) |
| | marc-4 | RING-CH-type domain-containing protein. (317 aa) |
| | ptr-5 | SSD domain-containing protein. (961 aa) |
| | ptr-4 | SSD domain-containing protein. (960 aa) |
| | ptr-3 | SSD domain-containing protein. (927 aa) |
| | imp-1 | IntraMembrane Protease (IMPAS) family. (662 aa) |
| | pgp-2 | p-GlycoProtein related. (1296 aa) |
| | rsd-3 | ENTH domain-containing protein. (483 aa) |
| | gop-1 | Protein CLEC16A homolog; Regulator of mitophagy. (892 aa) |
| | ptr-2 | SSD domain-containing protein. (933 aa) |
| | lgg-1 | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] (123 aa) |
| | C30B5.2 | Vacuolar protein sorting-associated protein 55 homolog; Involved in endosomal protein transport. (132 aa) |
| | vps-22 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (269 aa) |
| | rap-2 | RAP homolog (Vertebrate Rap GTPase family). (181 aa) |
| | ptr-1 | SSD domain-containing protein. (956 aa) |
| | maa-1 | ACB domain-containing protein. (266 aa) |
| | tsp-21 | Tetraspanin-21; Regulates cell fate specification in the postembryonic mesodermal M lineage and body size, probably by positively modulating BMP-like Sma/Mab signaling at the ligand-receptor level. Promotes ventral fate specification in the M lineage, probably by positively modulating lin-12/Notch signaling; Belongs to the tetraspanin (TM4SF) family. (301 aa) |
| | ocrl-1 | Rho-GAP domain-containing protein. (768 aa) |
| | copd-1 | Probable coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (515 aa) |
| | tsg-101 | Tumor Susceptibility Gene homolog. (425 aa) |
| | hgrs-1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. (729 aa) |
| | lmtr-3 | Late endosomal/lysosomal adaptor, Mapk (MAPK) and mToR (MTOR) activator homolog. (145 aa) |
| | mvb-12 | MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa) |
| | lmp-2 | LAMP (Lysosome-associated membrane protein) homolog. (296 aa) |
| | snx-1 | PX domain-containing protein. (472 aa) |
| | vps-16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the la [...] (852 aa) |
| | lmp-1 | LAMP family protein lmp-1; Belongs to the LAMP family. (237 aa) |
| | dyn-1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa) |
| | cup-4 | Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (433 aa) |
| | C01A2.4 | Uncharacterized protein. (207 aa) |
| | emc-5 | EMC Endoplasmic Membrane protein Complex (Yeast EMC) homolog. (144 aa) |
| | memb-1 | Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (213 aa) |
| | egg-1 | LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...] (551 aa) |
| | ida-1 | Receptor-type tyrosine-protein phosphatase-like ida-1; Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. (767 aa) |
